Reference equation for maximal voluntary ventilation in children and adolescents.

Abstract:

OBJECTIVES:To develop reference equations of maximal voluntary ventilation (MVV) in children and adolescents, and to test the validity and reproducibility of MVV. STUDY DESIGN:Cross-sectional study. PATIENT-SUBJECT SELECTION:A total of 348 healthy volunteers (6-17 years)-248 for the development of reference equations and 100 to test the validity- were selected. METHODOLOGY:Spirometry and MVV were performed. Volunteers were instructed to breathe quickly and strongly to estimate the MVV. Independent variables tested were age, sex, weight, height, and pulmonary function. RESULTS:All volunteers (50% boys) had a normal pulmonary function. Mean MVV was 66.3 (17.8) L/minute for children and 118.8 (20.0) L/minute for adolescents. The equation developed for children was MVV = 4.865 + (forced expiratory volume in the first second [FEV1]  × 16.257) + (peak expiratory flow [PEF] × 7.621); for adolescents was MVV = -25.450 + (FEV1  × 11.591) + (PEF × 6.672) + (sex × 12.179) + (age × 3.613). No significant differences were observed between measured and predicted MVV in children (64.6 [10.3] vs 64.6 [8.5] L/minute; P = .34) or adolescents (111.8 [23.4] vs 113.1 [22.8] L/minute, P = .12). The intraclass correlation coefficient between measured and predicted MVV was 0.95 (0.91-0.97) for children and 0.90 (0.82-0.94) for adolescents. The mean bias of Bland-Altman analysis was -0.8 L/minute for children and -2.7 L/minute for adolescents. CONCLUSIONS:Normative values for MVV were established for children and adolescents, additionally, these equations are reproducible and it can be used to determine the respiratory impairments in the pediatric population.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Silva JC,Carvalho IE,Dal Corso S,Lanza FC

doi

10.1002/ppul.24576

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

426-432

issue

2

eissn

8755-6863

issn

1099-0496

journal_volume

55

pub_type

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