Abstract:
OBJECTIVES:To develop reference equations of maximal voluntary ventilation (MVV) in children and adolescents, and to test the validity and reproducibility of MVV. STUDY DESIGN:Cross-sectional study. PATIENT-SUBJECT SELECTION:A total of 348 healthy volunteers (6-17 years)-248 for the development of reference equations and 100 to test the validity- were selected. METHODOLOGY:Spirometry and MVV were performed. Volunteers were instructed to breathe quickly and strongly to estimate the MVV. Independent variables tested were age, sex, weight, height, and pulmonary function. RESULTS:All volunteers (50% boys) had a normal pulmonary function. Mean MVV was 66.3 (17.8) L/minute for children and 118.8 (20.0) L/minute for adolescents. The equation developed for children was MVV = 4.865 + (forced expiratory volume in the first second [FEV1] × 16.257) + (peak expiratory flow [PEF] × 7.621); for adolescents was MVV = -25.450 + (FEV1 × 11.591) + (PEF × 6.672) + (sex × 12.179) + (age × 3.613). No significant differences were observed between measured and predicted MVV in children (64.6 [10.3] vs 64.6 [8.5] L/minute; P = .34) or adolescents (111.8 [23.4] vs 113.1 [22.8] L/minute, P = .12). The intraclass correlation coefficient between measured and predicted MVV was 0.95 (0.91-0.97) for children and 0.90 (0.82-0.94) for adolescents. The mean bias of Bland-Altman analysis was -0.8 L/minute for children and -2.7 L/minute for adolescents. CONCLUSIONS:Normative values for MVV were established for children and adolescents, additionally, these equations are reproducible and it can be used to determine the respiratory impairments in the pediatric population.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Silva JC,Carvalho IE,Dal Corso S,Lanza FCdoi
10.1002/ppul.24576subject
Has Abstractpub_date
2020-02-01 00:00:00pages
426-432issue
2eissn
8755-6863issn
1099-0496journal_volume
55pub_type
杂志文章abstract::To determine whether doses of ipratropium bromide (IB) greater than those usually administered by aerosol (75-250 micrograms) give a greater degree of protection from exercise-induced asthma (EIA) in children, 12 patients with chronic asthma, ages 7-13 yr, were challenged with methacholine and exercise after inhalatio...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(200006)29:6<476::aid-ppul1
更新日期:2000-06-01 00:00:00
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journal_title:Pediatric pulmonology
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doi:10.1002/ppul.1950060303
更新日期:1989-01-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2016-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20899
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
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更新日期:1996-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ppul.21147
更新日期:2010-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20712
更新日期:2007-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21424
更新日期:2011-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,多中心研究
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199808)26:2<101::aid-ppul5
更新日期:1998-08-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,meta分析
doi:10.1002/ppul.24270
更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00