Determining the optimal timing of liver transplant for pediatric patients after Kasai portoenterostomy based on disease severity scores.

Abstract:

BACKGROUND:The objective of this study was to determine the most optimal timing of liver transplant (LT) for post-Kasai portoenterostomy (KPE) patients based on disease severity scores. METHODS:This was a retrospective study and the clinical data of all LT recipients aged <18 years (n = 89) with a history of KPE were analyzed. They were divided into three groups according to their PELD/MELD scores at the time of LT (A: <15; B: 15-25; C: >25). The effects of LT on the clinical outcomes and hospitalization status were analyzed. RESULTS:There were 33, 34 and 22 patients in group A, B and C, respectively. There was no significant difference in 3-year graft survival rate between the three groups but group C patients had the highest incidence of vascular or biliary complications (p = 0.022). Group C patients had a significantly lower hospital admission frequency (p = 0.036) and shorter hospital stay (p = 0.041) after LT when compared with their pre-LT status and with non-LT patients with similar disease severity scores. On the other hand, the hospitalization frequency and duration were similar in patients with the lowest disease severity score (group A) before, after and without LT. CONCLUSIONS:The benefit of LT was less obvious when the disease severity score is <15. A high complication rate was reported when LT was performed at a score > 25. Donor availability, the patient's general condition and parental wish should be considered during individual assessment. TYPE OF STUDY:Clinical research paper. LEVEL OF EVIDENCE:Level III.

journal_name

J Pediatr Surg

authors

Chung PHY,Chok KSH,Wong KKY,Tam PKH,Lo CM

doi

10.1016/j.jpedsurg.2019.10.016

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1892-1896

issue

9

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(19)30751-1

journal_volume

55

pub_type

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