Abstract:
BACKGROUND:Not all adults with chronic insomnia respond to the recommended therapeutic options of cognitive behavioral therapy and approved hypnotic drugs. Transcranial alternating current stimulation (tACS) may offer a novel potential treatment modality for insomnia. OBJECTIVES:This study aimed to examine the efficacy and safety of tACS for treating adult patients with chronic insomnia. METHODS:Sixty-two participants with chronic primary insomnia received 20 daily 40-min, 77.5-Hz, 15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas in the laboratory on weekdays for 4 consecutive weeks, followed by a 4-week follow-up period. The primary outcome was response rate measured by the Pittsburgh Sleep Quality Index (PSQI) at week 8. Secondary outcomes were remission rate, insomnia severity, sleep onset latency (SOL), total sleep time (TST), sleep efficiency, sleep quality, daily disturbances, and adverse events at the end of the 4-week intervention and at the 4-week follow-up. RESULTS:Of 62 randomized patients, 60 completed the trial. During the 4-week intervention, 1 subject per group withdrew due to loss of interest and time restriction, respectively. Based on PSQI, at 4-week follow-up, the active group had a higher response rate compared to the sham group (53.4% [16/30] vs. 16.7% [5/30], p = 0.009), but remission rates were not different between groups. At the end of the 4-week intervention, the active group had higher response and remission rates than the sham group (p < 0.001 and p = 0.026, respectively). During the trial, compared with the sham group, the active group showed a statistically significant decrease in PSQI total score, a shortened SOL, an increased TST, improved sleep efficiency, and improved sleep quality (p < 0.05 or p < 0.001). Post hoc analysis revealed that, in comparison with the sham group, the active group had improved symptoms, except for daily disturbances, at the end of the 4-week intervention, and significant improvements in all symptoms at the 4-week follow-up. No adverse events or serious adverse responses occurred during the study. CONCLUSION:The findings show that the tACS applied in the present study has potential as an effective and safe intervention for chronic insomnia within 8 weeks.
journal_name
Psychother Psychosomjournal_title
Psychotherapy and psychosomaticsauthors
Wang HX,Wang L,Zhang WR,Xue Q,Peng M,Sun ZC,Li LP,Wang K,Yang XT,Jia Y,Zhou QL,Xu ZX,Li N,Dong K,Zhang Q,Song HQ,Zhan SQ,Min BQ,Fan CQ,Zhou AH,Guo XH,Li HB,Liang LR,Yin L,Si TM,Huang J,Yan TY,Cosci Fdoi
10.1159/000504609subject
Has Abstractpub_date
2020-01-01 00:00:00pages
38-47issue
1eissn
0033-3190issn
1423-0348pii
000504609journal_volume
89pub_type
杂志文章,随机对照试验abstract:BACKGROUND:According to Grawe's psychological therapy approach, conflict reduction can be expected not only in psychodynamic, but also in cognitive-behavioral therapy (CBT). This was tested in an effectiveness study. Changes in cognitive conflicts, along with those of symptom severity and well-being were analyzed durin...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000056255
更新日期:2001-07-01 00:00:00
abstract::It used to be fashionable to begin consideration of psychosomatics about philosophy of mind and body. Nowadays it is a topic about health and practical care of patients--principally about the psychological aspects of any illness. Pathogenesis is becoming understood with some risk factors clearly identifiable. The high...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000288009
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:We explored whether medical health workers had more psychosocial problems than nonmedical health workers during the COVID-19 outbreak. METHODS:An online survey was run from February 19 to March 6, 2020; a total of 2,182 Chinese subjects participated. Mental health variables were assessed via the Insomnia Sev...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000507639
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The present study compared the efficacy of psychotherapy for childhood anxiety disorders (excluding trials solely treating post-traumatic stress disorder or obsessive-compulsive disorder). METHODS:The meta-analysis included studies that met the basic CONSORT (consolidated standards of reporting trials) crit...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,meta分析
doi:10.1159/000096361
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The negative effects of vicarious traumatization through trauma work are well known. However, a growing body of evidence testifies to the positive effects that have been reported following trauma. This study explored the potential positive effects of trauma work on therapists, with a focus on the association...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000084004
更新日期:2005-01-01 00:00:00
abstract::Although cognitive dysfunctions in psychosis have classically been associated with schizophrenia, there is clinical evidence that some bipolar patients show cognitive disturbances either during acute phases or in remission periods. The authors critically review the data on cognitive impairment in bipolar disorder. The...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000012361
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to find out whether alexithymia is common in frequently attending primary health care patients and whether alexithymia and psychological distress are associated in these patients. METHODS:Alexithymia was measured by the TAS-26 and psychological distress by the SCL-25 in a ra...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000289075
更新日期:1996-01-01 00:00:00
abstract::51 patients on chronic dialysis, awaiting transplantation, were assessed using a standardised psychiatric interview, together with measures of anxiety, depression, locus of control and social adjustment. 33% of the patients warranted a psychiatric diagnosis. During the study period, 30 patients received a transplanted...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288297
更新日期:1989-01-01 00:00:00
abstract::Psychopathology and verbal expression were investigated in 20 psychoneurotic patients and 20 psychosomatic patients (10 patients with ulcerative colitis and 10 patients with Crohn's disease). The Crohn's disease patients showed as much psychopathology as the psychoneurotic patients, but the ulcerative colitis patients...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287620
更新日期:1982-01-01 00:00:00
abstract::The personality trait of alexithymia was assessed in 95 patients (35 male, 60 female) with affective illnesses, receiving lithium prophylactically, by means of Schalling-Sifneos Personality Scale (SSPS). The mean SSPS score was similar to that of the healthy population: only 8 patients had a score below 50 points. No ...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288058
更新日期:1988-01-01 00:00:00
abstract::Past studies have found that medical patients with the diagnosis of depression (comorbidity) have longer hospital lengths of stay (LOS) than those without the diagnosis of depression. This suggested that scores on a depression scale would be positively correlated with LOS. On a rehabilitation ward, 14 stroke and 17 am...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288575
更新日期:1992-01-01 00:00:00
abstract::Clinical and laboratory observations of alexithymia suggest that a neurophysiologic hypothesis may be more useful than the traditional psychodynamic explanations for understanding psychosomatic processes. Current data support the concept of a functional disconnection between the two cerebral hemispheres. A mechanism f...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287557
更新日期:1982-01-01 00:00:00
abstract::We have described examples of behaviors that occur antecedent to, concurrent with, or as a consequence of childhood asthma. Ways these patterns can be altered have also been described. Three points should be emphasized: first, social learning techniques can contribute to a child acquiring self-monitoring and self-mana...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000287396
更新日期:1979-01-01 00:00:00
abstract::The occurrence of the hyperventilation syndrome (HVS) has often been associated with stress. In this experiment with normal subjects responses of PACO2, respiration rate, heart rate and checklist measures were registered in a stressful, real-life situation, namely waiting for an examination. Heart rate and one checkli...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287434
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Many antidepressant medications (ADM) are associated with disruptions in sleep continuity that can compromise medication adherence and impede successful treatment. The present study investigated whether mindfulness meditation (MM) training could improve self-reported and objectively measured polysomnographic...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1159/000332755
更新日期:2012-01-01 00:00:00
abstract::The impact of the loss of the breast in women undergoing surgical treatment for breast cancer is subordinated to the confrontation with the diagnosis of a malignancy in causing depression. The equal distribution of depression in mastectomy and in lumpectomy patients supports the hypothesis that it is the confrontation...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288153
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Despite evidence that cognitive-behavioral therapy (CBT) is effective for rheumatoid arthritis (RA), little is known about which components of therapy are most efficacious. The present study compared the efficacy of CBT with cognitive therapy (CT) and behavioral therapy (BT) for patients with RA. We hypothes...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1159/000332334
更新日期:2012-01-01 00:00:00
abstract::In this prospective study a psychological test (the "Maastricht Questionnaire') was constructed which measures feelings of vital exhaustion and depression. It is shown that those subjects who have elevated scores on this test have more chance to get a new coronary event within a period of 10 months than those who have...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287458
更新日期:1980-01-01 00:00:00
abstract::In a prospective study to identify psychological factors affecting survival in cancer patients receiving radiation therapy, 101 consecutive patients were evaluated for anxiety, depression, and perception of the seriousness of the condition. In 3 years, the survivors were compared to the nonsurvivors. The survivors had...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288000
更新日期:1987-01-01 00:00:00
abstract::The functions and dysfunctions of slow wave sleep and of REM sleep and its associated dreams have a tremendous significance in understanding the psychosomatic model of illness and in establishing preventive strategies. Ten patients suffering from a variety of psychosomatic illnessess spent 3-4 nights sleeping at the D...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000286998
更新日期:1976-01-01 00:00:00
abstract::Results of a study of over 100 children whose father killed their mother have been summarized and principles for practice have been formulated. All children orphaned by the death of one parent at the other's hands should be seen as soon as possible in a child psychiatry department and assessed. An immediate crisis int...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288592
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Ketamine has shown rapid though short-lived antidepressant effects. The possibility of concerning neurobiological changes following repeated exposure to the drug motivates the development of strategies that obviate or minimize the need for longer-term treatment with ketamine. In this open-label trial, we i...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,多中心研究
doi:10.1159/000457960
更新日期:2017-01-01 00:00:00
abstract::The purpose of this paper is to reflect on and to compare various psychoanalytic models which are used in the conceptualisation of the processes occurring in small psychotherapeutic groups. Three tendencies are roughly differentiated: (1) the tendency to analyse the individual patient in the group (Slavson, Wolfson an...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287440
更新日期:1980-01-01 00:00:00
abstract::Phobic patients have been shown to be, on average, more hypnotizable than others. The essence of the phobic experience is not unlike that of the event of hypnosis, and the phobic experience might be a spontaneously occurring panic-filled trance-like or dissociative experience. This dissociation is viewed as a maladapt...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287509
更新日期:1981-01-01 00:00:00
abstract::Psychiatric clinicians frequently prescribe biologic treatments such as antidepressant medication in combination with psychologic treatments such as psychotherapy. In the present article we propose a model integrating antidepressant treatment with Beck's cognitive therapy, a form of psychotherapy with established effi...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000288892
更新日期:1994-01-01 00:00:00
abstract::Some patients become grossly disorganized during a hospital stay for medical illness. In the midst of a confusing medical picture, the unpredictable behavior of such patients causes great consternation among the medical or surgical staff. Families also become particularly anxious; their concern about the medical probl...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287284
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:There is a lack of scientific consensus about cancer comorbidity in people with central nervous system (CNS) disorders. This study assesses the co-occurrence of cancers in patients with CNS disorders, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), autism spectrum disorders, Down's s...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,meta分析
doi:10.1159/000356498
更新日期:2014-01-01 00:00:00
abstract::It is generally conceded that allergic disorders occur in individuals who have a hereditary or congenital allergic constitution. Clinical symptoms of allergic disorders, however, often disappear due to changes of the individuals' life situations and/or their adaptive patterns. In a comparative study of allergic predis...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287331
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Instruments that are intended to measure change over time need to emphasize sensitivity to change as a central property. The aims of this report are to test whether the MOODS-SR, a measure of mood spectrum symptomatology, is sensitive to changes during acute and continuation treatment of depression and wheth...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1159/000201937
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Exercise training may be especially helpful for patients with generalized anxiety disorder (GAD). We conducted a randomized controlled trial to quantify the effects of 6 weeks of resistance (RET) or aerobic exercise training (AET) on remission and worry symptoms among sedentary patients with GAD. METHODS:Th...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1159/000327898
更新日期:2012-01-01 00:00:00