Hair Cortisol Concentration in Healthy Children and Adolescents Is Related to Puberty, Age, Gender, and Body Mass Index.

Abstract:

INTRODUCTION:Hair cortisol concentrations (HCC) have been found to be related to various common childhood diseases, like otitis media, conjunctivitis, respiratory viral infections, and asthma. However, the confounding effects of age, gender, body mass index (BMI), pubertal stage (Tanner stages), socioeconomic status (SES) as well as of some hair maintenance procedures on HCC are still not well examined. METHODS:A population-based cohort of 434 children aged between 5 and 18 years was examined for HCC between January 2012 and February 2015 in the context of the Leipzig Research Centre for Civilization Diseases (LIFE) Child study. Thereby, anthropometric data, gender, BMI, SES and pubertal status were assessed. HCC was measured by liquid chromatography mass spectrometry. RESULTS:In the total cohort, HCC levels ranged between 0.95 and 29.86 pg/mg. In prepuberty, boys showed significantly higher HCC than girls (6.54 vs. 3.73 pg/mg, p < 0.05). During puberty HCC values in both genders converged. Higher BMI was significantly associated with higher HCC in both genders. In girls, HCC did not differ depending on Tanner stages. In boys, HCC was significantly higher in Tanner stage 1 than in stages 2-5. CONCLUSION:Measuring cortisol concentration in hair gives information about long-term release of cortisol. We have found that puberty, gender, and BMI had a profound effect on HCC. As a result, further research should take into account the potentially confounding role of puberty, gender and BMI and may use the results of our study as a reference at determining values of HCC in healthy children.

journal_name

Horm Res Paediatr

authors

Wagner M,Kratzsch J,Vogel M,Peschel T,Gaudl A,Ceglarek U,Thiery J,Hiemisch A,Körner A,Kiess W

doi

10.1159/000504914

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

237-244

issue

4

eissn

1663-2818

issn

1663-2826

pii

000504914

journal_volume

92

pub_type

杂志文章
  • Why is the thyroid so prone to autoimmune disease?

    abstract::The thyroid gland plays a major role in the human body; it produces the hormones necessary for appropriate energy levels and an active life. These hormones have a critical impact on early brain development and somatic growth. At the same time, the thyroid is highly vulnerable to autoimmune thyroid diseases (AITDs). Th...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000324442

    authors: Saranac L,Zivanovic S,Bjelakovic B,Stamenkovic H,Novak M,Kamenov B

    更新日期:2011-01-01 00:00:00

  • MKRN3 mutations in familial central precocious puberty.

    abstract::Loss-of-function mutations in the gene encoding the makorin RING finger protein 3 (MKRN3) have recently been reported to underlie familial cases of central precocious puberty (CPP). The imprinted MKRN3 gene is expressed only from the paternal allele, and mutations inherited from the father affect boys and girls equall...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000362815

    authors: Schreiner F,Gohlke B,Hamm M,Korsch E,Woelfle J

    更新日期:2014-01-01 00:00:00

  • Water Balance and 'Salt Wasting' in the First Year of Life: The Role of Aldosterone-Signaling Defects.

    abstract::In newborns and infants, dehydration and salt wasting represent a relatively common cause of admission to hospital and may result in life-threatening complications. Kidneys are responsible for electrolyte homoeostasis, but neonatal kidneys show low glomerular filtration rate and immaturity of the distal nephron, leadi...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000449057

    authors: Bizzarri C,Pedicelli S,Cappa M,Cianfarani S

    更新日期:2016-01-01 00:00:00

  • Short-Term Vitamin D3 Supplementation in Children with Neurodisabilities: Comparison of Two Delivery Methods.

    abstract:BACKGROUND/AIMS:Vitamin D deficiency is common in children with neurodisabilities. Oral vitamin D3 may not be absorbed appropriately due to dysphagia and tube feeding. The aim of this study was to compare efficacy of vitamin D3 buccal spray with that of oral drops. METHODS:Twenty-four children with neurodisabilities (...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000479690

    authors: Penagini F,Borsani B,Maruca K,Giosia V,Bova S,Mastrangelo M,Zuccotti GV,Mora S

    更新日期:2017-01-01 00:00:00

  • Endothelial nitric oxide synthase T(-786)C polymorphism in children and adolescents with type 1 diabetes and impaired endothelium-dependent dilatation.

    abstract:BACKGROUND/AIMS:This study aimed to investigate the association of endothelial nitric oxide synthase (eNOS) polymorphisms with impaired endothelium-dependent dilatation (EDD) in a cohort of children and adolescents with type 1 diabetes. METHODS:Ninety-seven children and adolescents with type 1 diabetes underwent ultra...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000329549

    authors: Battelino N,Sebestjen M,Keber I,Blagus R,Hovnik T,Bratina N,Battelino T

    更新日期:2011-01-01 00:00:00

  • Usefulness of serum insulin-like growth factor I assessment in the diagnosis of childhood-onset growth hormone deficiency.

    abstract::The diagnosis of childhood-onset growth hormone (GH) deficiency (GHD) is not straightforward, requiring a comprehensive clinical, anthropometric, biochemical, endocrine, and neuroradiological assessment. Although pharmacological GH stimulation tests are still considered the gold standard for GHD diagnosis, they are bu...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000314895

    authors: Federico G,Cianfarani S

    更新日期:2010-01-01 00:00:00

  • Pubertal growth and serum testosterone and estradiol levels in boys.

    abstract:BACKGROUND/AIMS:To study serum testosterone and estradiol in healthy boys in relation to growth during puberty up to peak height velocity (PHV). METHODS:Growth velocity was analyzed through testosterone (n = 41) and 17β-estradiol (n = 37) 24-hour profiles in a dose-response model. Participants were 26 healthy boys adm...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000353761

    authors: Albin AK,Norjavaara E

    更新日期:2013-01-01 00:00:00

  • The Hypothalamic-Pituitary-Adrenal Axis and the Fetus.

    abstract::Glucocorticoids (GCs), cortisol in humans, influence multiple essential maturational events during gestation. In the human fetus, fetal hypothalamic-pituitary-adrenal (HPA) axis function, fetal adrenal steroidogenesis, placental 11β- hydroxysteroid dehydrogenase type 2 activity, maternal cortisol concentrations, and e...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000488106

    authors: Morsi A,DeFranco D,Witchel SF

    更新日期:2018-01-01 00:00:00

  • The predictive value of the individual components of the metabolic syndrome for insulin resistance in obese children.

    abstract:BACKGROUND/AIMS:The usefulness of the concept of the metabolic syndrome (MS) in its current form has recently been questioned, and its association with insulin resistance is unknown. We assessed whether a multivariate model based on all components of MS expressed on a continuous scale would be a better predictor of a c...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000327371

    authors: Vos RC,Houdijk EC,van der Kamp HJ,Pijl H,Wit JM

    更新日期:2011-01-01 00:00:00

  • Adherence to growth hormone therapy: a practical approach.

    abstract:BACKGROUND:Early detection of suspected poor adherence to growth hormone (GH) therapy is crucial to achieve normal final height in GH-deficient (GHD) patients. PATIENTS:106 children (73 M, 33 F) with a median age of 10.47±3.48 years (mean±standard deviation score (SDS)) exhibited short stature (-1.76±0.64 SDS) and a d...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000357975

    authors: Bozzola M,Pagani S,Iughetti L,Maffeis C,Bozzola E,Meazza C

    更新日期:2014-01-01 00:00:00

  • Prenatal Treatment of Congenital Adrenal Hyperplasia: Long-Term Effects of Excess Glucocorticoid Exposure.

    abstract::Prenatal treatment of congenital adrenal hyperplasia with dexamethasone (DEX) has been in use since the mid-1980s and has proven effective at reducing virilization of external genitalia in affected girls. However, multiple experimental studies on animals and clinical studies on humans show that prenatal administration...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000485100

    authors: Lajic S,Karlsson L,Nordenström A

    更新日期:2018-01-01 00:00:00

  • Preserved fertility in a patient with a 46,XY disorder of sex development due to a new heterozygous mutation in the NR5A1/SF-1 gene: evidence of 46,XY and 46,XX gonadal dysgenesis phenotype variability in multiple members of an affected kindred.

    abstract::In humans, steroidogenic factor 1 (NR5A1/SF-1) mutations have been reported to cause gonadal dysgenesis, with or without adrenal failure, in both 46,XY and 46,XX individuals. We have previously reported extreme within-family variability in affected 46,XY patients. Even though low ovarian reserve with preserved fertili...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000338346

    authors: Ciaccio M,Costanzo M,Guercio G,De Dona V,Marino R,Ramirez PC,Galeano J,Warman DM,Berensztein E,Saraco N,Baquedano MS,Chaler E,Maceiras M,Lazzatti JM,Rivarola MA,Belgorosky A

    更新日期:2012-01-01 00:00:00

  • Molecular and gene network analysis of thyroid transcription factor 1 (TTF1) and enhanced at puberty (EAP1) genes in patients with GnRH-dependent pubertal disorders.

    abstract:BACKGROUND/AIM:TTF1 and EAP1 are transcription factors that modulate gonadotropin-releasing hormone expression. We investigated the contribution of TTF1 and EAP1 genes to central pubertal disorders. PATIENTS AND METHODS:133 patients with central pubertal disorders were studied: 86 with central precocious puberty and 4...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000354643

    authors: Cukier P,Wright H,Rulfs T,Silveira LF,Teles MG,Mendonca BB,Arnhold IJ,Heger S,Latronico AC,Ojeda SR,Brito VN

    更新日期:2013-01-01 00:00:00

  • Thyroid Sequelae of Pediatric Cancer Therapy.

    abstract::The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms ca...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000495040

    authors: Waguespack SG

    更新日期:2019-01-01 00:00:00

  • Marginal growth increase, altered bone quality and polycystic ovaries in female prepubertal rats after treatment with the aromatase inhibitor exemestane.

    abstract:BACKGROUND:Aromatase inhibition has been proposed as a potential approach for growth enhancement in children with short stature, but detailed animal studies are lacking. AIM:To assess the effect and potential adverse effects of aromatase inhibition on growth in female rats. METHODS:Prepubertal Wistar rats received in...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000271916

    authors: van Gool SA,Wit JM,De Schutter T,De Clerck N,Postnov AA,Kremer Hovinga S,van Doorn J,Veiga SJ,Garcia-Segura LM,Karperien M

    更新日期:2010-01-01 00:00:00

  • Influence of fetal growth velocity and smallness at birth on adrenal function in adolescence.

    abstract::The hypothalamic-pituitary-adrenal axis is susceptible to programming during fetal development and may be linked to risk of disease later in life. In a former prospective study the cohort was divided into those born appropriate for gestational age (AGA) or small for gestational age (SGA; birth weight <10 percentile). ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000315656

    authors: Beck Jensen R,Vielwerth S,Larsen T,Hilsted L,Cohen A,Hougaard DM,Jensen LT,Greisen G,Juul A

    更新日期:2011-01-01 00:00:00

  • Gonadotropin-dependent precocious puberty in an 8-year-old boy with leydig cell testicular tumor.

    abstract::Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose hormonal investigation showed luteinizing hormone-independent testosterone hypersecretion. Al...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000358084

    authors: Santos-Silva R,Bonito-Vítor A,Campos M,Fontoura M

    更新日期:2014-01-01 00:00:00

  • Thyroid function patterns at Hashimoto's thyroiditis presentation in childhood and adolescence are mainly conditioned by patients' age.

    abstract:BACKGROUND:There are few studies investigating the factors which may affect different biochemical presentations of Hashimoto's thyroiditis (HT) and these are frequently based on limited pediatric populations. AIMS:(1) To assess the frequency of thyroid function patterns at HT diagnosis in 608 children and adolescents,...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000343815

    authors: Wasniewska M,Corrias A,Salerno M,Mussa A,Capalbo D,Messina MF,Aversa T,Bombaci S,De Luca F,Valenzise M

    更新日期:2012-01-01 00:00:00

  • Health problems in congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract::Following the introduction of life-saving glucocorticoid replacement 60 years ago, congenital adrenal hyperplasia (CAH) has evolved from being perceived as a paediatric disorder to being recognized as a lifelong, chronic condition affecting patients of all age groups. Increasing evidence suggests that patients with CA...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000327794

    authors: Reisch N,Arlt W,Krone N

    更新日期:2011-01-01 00:00:00

  • Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency.

    abstract:BACKGROUND:Hyperandrogenism is a rare symptom of juvenile ovarian granulosa cell- tumors (JGCTO). This study aimed to determine whether hyperandrogenism was related to overexpression of SOX9, decreased expression of FOXL2 or absent aromatase expression in tumor with particular scheme of expression of P450scc and P450c1...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000313396

    authors: Kalfa N,Méduri G,Philibert P,Patte C,Boizet-Bonhoure B,Thibaut E,Pienkowski C,Jaubert F,Misrahi M,Sultan C

    更新日期:2010-01-01 00:00:00

  • Absence of Testicular Adrenal Rest Tumors in Newborns, Infants, and Toddlers with Classical Congenital Adrenal Hyperplasia.

    abstract:INTRODUCTION:Testicular adrenal rest tumors (TART) are a known consequence for males with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. TART are associated with potential infertility in adults. However, little is known about TART in very young males with CAH. OBJECTIVE:We assessed th...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000504135

    authors: Kim MS,Koppin CM,Mohan P,Goodarzian F,Ross HM,Geffner ME,De Filippo R,Kokorowski P

    更新日期:2019-01-01 00:00:00

  • Serum fibroblast growth factor 23 is a useful marker to distinguish vitamin D-deficient rickets from hypophosphatemic rickets.

    abstract:BACKGROUND/AIMS:Vitamin D-deficient rickets (DR) has recently re-emerged among developed countries. Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult. In the present study ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000357142

    authors: Kubota T,Kitaoka T,Miura K,Fujiwara M,Ohata Y,Miyoshi Y,Yamamoto K,Takeyari S,Yamamoto T,Namba N,Ozono K

    更新日期:2014-01-01 00:00:00

  • Experience of Octreotide Therapy for Hyperinsulinemic Hypoglycemia in Neonates Born Small for Gestational Age: A Case Series.

    abstract:AIMS:Hyperinsulinemic hypoglycemia (HH) is common in small-for-gestational-age (SGA) neonates. Diazoxide is often used as the first-line medication for HH in SGA neonates. Unfortunately, diazoxide is not authorized in China. We examined the effectiveness of octreotide as an alternative therapy to treat HH in SGA neonat...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000441108

    authors: Pan S,Zhang M,Li Y

    更新日期:2015-01-01 00:00:00

  • Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism.

    abstract::Feeding problems are frequent in infants with congenital hyperinsulinism (HI) and may be exacerbated by continuous enteral nutrition (EN) used to maintain euglycemia. Our center's HI team uses dextrose solution given continuously via gastric tube (intrasgastric dextrose, IGD) for infants not fully responsive to conven...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验

    doi:10.1159/000491105

    authors: Vajravelu ME,Congdon M,Mitteer L,Koh J,Givler S,Shults J,De León DD

    更新日期:2019-01-01 00:00:00

  • Gastric autoimmunity in children and adolescents with type 1 diabetes: a prospective study.

    abstract:BACKGROUND/AIMS:Type 1 diabetes (T1DM) is associated with gastric autoimmunity, which is characterized by the presence of parietal cell antibodies (APCA). We investigated gastric autoimmunity prevalence in T1DM children, its manifestations, determinants and association with thyroid gland (anti-Tg, anti-TPO) and pancrea...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000336923

    authors: Kakleas K,Kostaki M,Critselis E,Karayianni C,Giannaki M,Anyfantakis K,Haramaras I,Fotinou A,Papathanasiou A,Karavanaki K

    更新日期:2012-01-01 00:00:00

  • Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty.

    abstract:BACKGROUND:The flare-up effect of GnRH analogues may cause transient uterine bleeding in girls affected with idiopathic central precocious puberty (ICPP). AIMS:To assess the incidence of endometrial bleeding and verify whether pretreatment with cyproterone acetate could counteract it. METHODS:Fifty-four girls affecte...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000308172

    authors: Seminara S,Nanni L,Generoso M,Mirri S,Leonardi V,Slabadzianiuk T,Vetrano ML,Buongiorno A,Losi S,Galluzzi F

    更新日期:2010-01-01 00:00:00

  • Metabolic syndrome in children: comparison of the International Diabetes Federation 2007 consensus with an adapted National Cholesterol Education Program definition in 300 overweight and obese French children.

    abstract:BACKGROUND/AIMS:Former definitions of metabolic syndrome (MS) in children have been adapted from adult MS definitions using age-related thresholds for each biochemical component, whereas the International Diabetes Federation (IDF) definition is based on absolute values. We compared the IDF childhood MS definition (IDF-...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000284359

    authors: Druet C,Ong K,Levy Marchal C

    更新日期:2010-01-01 00:00:00

  • The Diagnosis of Polycystic Ovary Syndrome during Adolescence.

    abstract:BACKGROUND/AIMS:The diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescence are controversial, primarily because the diagnostic pathological features used in adult women may be normal pubertal physiological events. Hence, international pediatric and adolescent specialty societies have defined criteria t...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000375530

    authors: Witchel SF,Oberfield S,Rosenfield RL,Codner E,Bonny A,Ibáñez L,Pena A,Horikawa R,Gomez-Lobo V,Joel D,Tfayli H,Arslanian S,Dabadghao P,Garcia Rudaz C,Lee PA

    更新日期:2015-04-01 00:00:00

  • Molecular Screening of MKRN3, DLK1, and KCNK9 Genes in Girls with Idiopathic Central Precocious Puberty.

    abstract:BACKGROUND:Mutations in the imprinted gene MKRN3 have been described as a common genetic cause of idiopathic central precocious puberty (CPP), in particular in familial cases. However, the exact prevalence of mutations is unknown. Single nucleotide polymorphisms in 2 other imprinted genes, DLK1 and KCNK9, have been ass...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000477441

    authors: Grandone A,Capristo C,Cirillo G,Sasso M,Umano GR,Mariani M,Miraglia Del Giudice E,Perrone L

    更新日期:2017-01-01 00:00:00

  • A novel homozygous Q334X mutation in the HSD3B2 gene causing classic 3β-hydroxysteroid dehydrogenase deficiency: an unexpected diagnosis after a positive newborn screen for 21-hydroxylase deficiency.

    abstract:BACKGROUND:3β-hydroxysteroid dehydrogenase (3βHSD) type 2 (encoded by HSD3B2) is expressed in the adrenals and gonads. HSD3B2 mutations cause the rare form of congenital adrenal hyperplasia '3βHSD deficiency'. In its classic form, affected individuals have salt wasting early in infancy and may have ambiguous genitalia ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000336004

    authors: Jeandron DD,Sahakitrungruang T

    更新日期:2012-01-01 00:00:00