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A soft tick Ornithodoros moubata salivary protein OmCI is a potent inhibitor to prevent avian complement activation.

Abstract：

:Complement is a key first line innate host defense system in the blood of vertebrates. Upon activation, this powerful defense mechanism can elicit inflammatory responses, lyse non-self-cells, or mark them for opsonophagocytic removal. Blood-feeding arthropods thus require the ability to block host complement activation in the bloodmeal to prevent undesired cell or tissue damage during feeding. The soft tick Ornithodoros moubata produces a complement inhibitory protein, OmCI. This protein binds to a mammalian complement protein C5 and blocks further activation of complement cascades, which results in the prevention of complement-mediated bacterial killing through membrane attack complex. Interestingly, the amino acids involved in OmCI binding are highly conserved among mammalian and avian C5, but the ability of this protein to inhibit the complement from birds remains unclear. Here we demonstrated that OmCI is capable of preventing quail complement-mediated erythrocyte lysis, inhibiting the capability of this animal's complement to eliminate a serum-sensitive Lyme disease bacterial strain. We also found that the ability of OmCI to inhibit quail complement-mediated killing of Lyme disease bacteria can be extended to different domestic and wild birds. Our results illustrate the utility of OmCI to block bird complement. These results provide the foundation for further use of this protein as a tool to study the molecular basis of avian complement and pathogen evasion to such a defense mechanism.

journal_name

Ticks Tick Borne Dis

journal_title

Ticks and tick-borne diseases

authors

Frye AM,Hart TM,Tufts DM,Ram S,Diuk-Wasser MA,Kraiczy P,Blom AM,Lin YP

doi

10.1016/j.ttbdis.2019.101354

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

101354

issue

2

eissn

1877-959X

issn

1877-9603

pii

S1877-959X(19)30255-9

journal_volume

11

pub_type

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