Abstract:
INTRODUCTION:Regional metastases of cutaneous head and neck squamous cell carcinoma occur in approximately 5 % of cases, being the most important prognostic factor in survival, currently with no distinction between parotid and neck metastasis. OBJECTIVE:The purpose of this study was to evaluate the prognostic features among patients with head and neck cutaneous squamous cell carcinoma exhibiting regional metastasis. METHODS:A retrospective analysis of patients with cutaneous squamous cell carcinoma who underwent parotidectomy and/or neck dissection from 2011 to 2018 at a single institution tertiary center was performed. Patient demographics, clinical, surgical and pathological information, adjuvant treatments, and outcome at last follow-up were collected. Outcomes included disease recurrence and death due to the disease. Prognostic value of clinic pathological features associated with disease-specific survival was obtained. RESULTS:Thirty-eight cases of head and neck cutaneous squamous cell carcinoma with parotid and/or neck metastasis were identified. Overall, 18 (47.3 %) patients showed parotid metastasis alone, 12 (31.5 %) exhibited neck metastasis alone and 8 (21.0 %) had both. A primary tumor in the parotid zone (Hazard Ratio ‒ HR = 5.53; p = 0.02) was associated with improved disease-specific survival. Poorer disease-specific survival was observed in patients with higher primary tumor diameter (HR = 1.54; p = 0.002), higher depth of invasion (HR = 2.89; p = 0.02), invasion beyond the subcutaneous fat (HR = 5.05; p = 0.002), neck metastasis at first presentation (HR = 8.74; p < 0.001), number of positive lymph nodes (HR = 1.25; p = 0.004), and higher TNM stages (HR = 7.13; p = 0.009). Patients presenting with isolated parotid metastasis during all follow-ups had better disease-specific survival than those with neck metastasis or both (HR = 3.12; p = 0.02). CONCLUSION:Head and neck cutaneous squamous cell carcinoma with parotid lymph node metastasis demonstrated better outcomes than cases with neck metastasis.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Girardi FM,Wagner VP,Martins MD,Abentroth AL,Hauth LAdoi
10.1016/j.bjorl.2019.10.007subject
Has Abstractpub_date
2019-11-15 00:00:00eissn
1808-8694issn
1808-8686pii
S1808-8694(19)30140-5pub_type
杂志文章abstract:INTRODUCTION:Misophonia is characterized by the aversion to very selective sounds, which evoke a strong emotional reaction. It has been inferred that misophonia, as well as tinnitus, is associated with hyperconnectivity between auditory and limbic systems. Individuals with bothersome tinnitus may have selective attenti...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.02.005
更新日期:2019-01-01 00:00:00
abstract:UNLABELLED:Children dysphonia studies have reported an incidence of 4.4 to 30.3%. GOALS:To establish the prevalence of dysphonia in children, based on the opinion of the parents, acoustic and vocal-perceptual assessments, associated symptoms, risk factors and videolaryngoscopy findings. MATERIALS AND METHODS:The pare...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:The evaluation of cortical auditory evoked potential has been the focus of scientific studies in infants. Some authors have reported that automated response detection is effective in exploring these potentials in infants, but few have reported their efficacy in the search for thresholds. OBJECTIVE:To anal...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.01.001
更新日期:2019-01-01 00:00:00
abstract:UNLABELLED:Exposure to ototoxic chemical products in the presence or absence of noise can cause irreversible injury to the hearing of workers for a significantly short period of exposure period. AIM:to perform a comparative study, through audiometric tests, in workers exposed to noise only and noise associated with ch...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30831-4
更新日期:2009-01-01 00:00:00
abstract:UNLABELLED:Cystic Fibrosis (CF) results from mutation in the transmembrane conductance regulator gene, responsible for controlling secretory processes. The upper airways (UA) are usually involved in the form of chronic pansinusitis. OBJECTIVE:To evaluate UA changes in patients with CF and to establish the correlations...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20130086
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Ménière's disease is among the most frequent causes of vestibular disorders. Although it is a clinical diagnosis, a better understanding of the pathophysiology and clinical course of the disease through tests would allow improvement in the prognosis and more effective treatments. OBJECTIVES:To describe th...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.02.002
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:Cleft lip and/or palate represent the most common congenital anomaly of the face. AIM:To describe the correlation between non-syndromic cleft lip and/or palate and gender, and its severity in the Brazilian population. METHODS:Cross-sectional study, between 2009 and 2011, in a sample of 366 patients. The da...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20120018
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Calcium is vital for the functioning of the inner ear hair cells as well as for the neurotransmitter release that triggers the generation of a nerve impulse. A reduction in calcium level could therefore impair the peripheric vestibular functioning. However, the outcome of balance assessment has rarely been...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2017.08.013
更新日期:2018-01-01 00:00:00
abstract::Glomus tumors, also called paragangliomas, originate from nonchromaffin cells. The tumor is typically vascular and grows from capillary and pre-capillary vessels in-between epithelial cells. It is worth mentioning that the most common symptoms are pulsating tinnitus and hearing loss. Imaging studies (CT and MRI) are n...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31293-3
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Percutaneous drains can be associated with several complications, including infection, fistula formation, discomfort and prolonged hospitalization. OBJECTIVE:The aim of this study was to evaluate the safety of submandibular gland excision without the use of surgical drains. METHODS:We analyzed the surger...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.04.010
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Adenotonsillectomy is an invasive surgical procedure, which may encourage the search for information by the lay population through online search engines. The quality of this information, however, requires an evaluation due to the wide diversity of the available content. OBJECTIVE:To evaluate the quality, ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.06.012
更新日期:2019-07-27 00:00:00
abstract:UNLABELLED:Recent studies analyzing audibility thresholds at frequencies over 8 KHz have brought new perspectives on the investigation of auditory damage. These studies, however, have not yet reached a consensus on normal standards for auditory thresholds at these frequencies. AIM:To analyze the results of high freque...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31069-7
更新日期:2007-03-01 00:00:00
abstract:UNLABELLED:Allergic rhinitis is an inflammation of the nasal mucosa caused by exposure to allergens, which impairs the cognitive capabilities of the affected. OBJECTIVE:To correlate the mean scores of quality of life of children and adolescents with symptoms of allergic rhinitis and the presence of household environme...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20130102
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Rhinosinusitis constitutes an important health problem, with significant interference in personal, professional, and social functioning. This study presents the validation process of the Portuguese version of the RhinoQOL, to be used as a routine procedure in the assessment of patients with chronic rhinosi...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2015.08.015
更新日期:2015-11-01 00:00:00
abstract:UNLABELLED:Benign Positional Paroxysmal Vertigo (BPPV) is one of the most common vestibular diseases and the active head rotation test one of the most modern methods of vestibular function assessment. AIM:this study aims to verify if the active head rotation test may reveal signs of horizontal and/or vertical vestibul...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30500-0
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:Otitis media, mastoiditis or the pressure effect of tumorous lesions such as cholesteatoma can be the cause of facial canal dehiscence and facial nerve paralysis. The most common segment involved in dehiscence is the tympanic segment and the second most common is the lateral aspect of the facial canal in t...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.03.005
更新日期:2019-01-01 00:00:00
abstract:UNLABELLED:Oral lichen planus is one of the most common dermatological diseases presenting in the oral cavity; the prevalence in the general population is 1% to 2%. Although relatively frequent, oral lichen planus is the target of much controversy, especially in relation to its potential for malignancy. AIM:This study...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.1016/s1808-8694(15)31102-2
更新日期:2008-03-01 00:00:00
abstract:INTRODUCTION:Mucopolysaccharidosis (MPS) is a lysosomal storage disease caused by deficiency of α-l-iduronidase. The otolaryngological findings include hearing loss, otorrhea, recurrent otitis, hypertrophy of tonsils and adenoid, recurrent rhinosinusitis, speech disorders, snoring, oral breathing and nasal obstruction....
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2015.09.006
更新日期:2016-09-01 00:00:00
abstract:UNLABELLED:The cervical lymph nodes are relevant due to the diversity of clinical entities. The use of immunohistochemistry is a real method to elucidate the diagnosis of adenopathy, both primary and metastatic neoplasms. OBJECTIVE:To assess the value of immunohistochemistry in the diagnosis of cervical lymph nodes ma...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20130112
更新日期:2013-09-01 00:00:00
abstract:UNLABELLED:The immunodeficiency state in HIV infected patients has been the cause of severe episodes of Recurrent Aphthous Stomatitis (RAS). AIM:Our study aims to establish correlation between the manifestations of RAS and the immunosuppression state caused by HIV infection, through counting of CD4+ cells, CD8+ cells,...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31209-x
更新日期:2005-07-01 00:00:00
abstract:INTRODUCTION AND AIMS:the Internet is the world's fastest growing source of health related information. Parents and guardians are increasingly turning to the Internet for information about their children's medical conditions and treatments. This paper has the following objectives 1) determine the prevalence of web sear...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract:UNLABELLED:The main issue regarding pediatric audiology diagnosis is determining procedures to configure reliable results which can be used to predict frequency-specific hearing thresholds. AIM:To investigate the correlation between auditory steady-state response (ASSR) with other tests in children with sensorineural ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:There is evidence that trauma caused by snoring in the pharynx could result in dysphagia in patients with obstructive sleep apnea, but the literature is still scarce to define the factors associated with the presence of dysphagia in these patients. AIM:To analyze the occurrence of dysphagia and its clinic...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2019.10.004
更新日期:2019-11-15 00:00:00
abstract:UNLABELLED:Cochlear implant surgery is regarded as safe for the auditory rehabilitation of individuals suffering from profound/severe hearing loss. Complications may arise from the surgery. The complications of implant cochlear surgery reflect the operation complexity, the skill of the surgical team and the inherent ri...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract:UNLABELLED:Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The disease more frequently affects the nasal mucosa and can occur independently of its clinical form or even before lesions on the skin or on other parts of the body. It is necessary to employ epidemiological surveillance of household c...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract::Squamous papillomas are benign neoplasms. The occurrence of middle ear squamous papilloma is rare. It is usually associated with nasosinusal pathology. The authors report a case of middle ear squamous papilloma and discuss its diagnostic aspects. ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31344-6
更新日期:2005-05-01 00:00:00
abstract:UNLABELLED:Cholesteatoma may occur either in children as in adults; in children, however, they have a more aggressive and extensive growth. OBJECTIVE:To compare the thickness of the perimatrix, in microm, between adults (>18 years old) and children cholesteatomas. STUDY DESIGN:transversal cohort. MATERIAL AND METHOD...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)31250-7
更新日期:2005-11-01 00:00:00
abstract:UNLABELLED:To setup an experimental model is the first step to study neural regeneration. AIM:Setting up an experimental model on facial nerve regeneration. MATERIAL AND METHODS:Wistar rats with complete sectioning and suturing of the extratemporal facial nerve trunk; with a behavioral and histological analysis for 9...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract:UNLABELLED:Ototoxicity of organic solvents can affect the hearing system up to the cochlea level and the central structures of hearing. OBJECTIVE:To evaluate the neurophysiological integrity of the hearing system in subjects exposed to fuels using ABR. METHOD:Prospective study. We evaluated attendants from three gas ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20120035
更新日期:2012-12-01 00:00:00
abstract:UNLABELLED:Conventional CT and MRI scans have low specificity when it comes to differentiating granulation tissue from relapsing cholesteatoma. AIM:this paper aims to analyze the use of DWI and delayed post-contrast T1-weighed imaging in the detection of recurring cholesteatomas. MATERIALS AND METHOD:this is a cross-...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/S1808-8694(15)31378-1
更新日期:2008-09-01 00:00:00