[A case of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) syndrome].

Abstract:

INTRODUCTION:DIPNECH is a strictly histological entity according to the WHO 2015 classification and is considered to be at pre-neoplastic risk. It has been proposed that DIPNECH syndrome should be used to describe patients have clinical symptoms, an obstructive ventilatory disorder and compatible radiological abnormalities. The diagnosis is histological and usually based on a surgical lung biopsy. CASE REPORT:We report the case of a 58-year-old woman with a chronic cough for over 20years who had an obstructive airway pattern on spirometry. Diagnoses of asthma and COPD had been discussed. After 7years of follow-up, the DIPNECH hypothesis was evoked on the scanning aspect of mosaic attenuation, expiratory trapping and micronodules, which was subsequently confirmed by surgical pulmonary biopsy. CONCLUSION:It is necessary to consider the possibility of this rare disease in order to avoid inappropriate treatments and in the hope that future therapeutic advances (somatostatin analogs, mTOR inhibitors) improve patients' experience and the progression of respiratory function.

journal_name

Rev Mal Respir

authors

Moussa Ounteini A,Aziagbe Koffi A,Rabiou S,Gbadamassi G,Efalou P,Effared B,Edingo Sheko J,Devin E,Philippe C,Dujon A,Adjoh K,Mehdaoui A

doi

10.1016/j.rmr.2019.10.011

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

75-79

issue

1

eissn

0761-8425

issn

1776-2588

pii

S0761-8425(19)31044-7

journal_volume

37

pub_type

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