Abstract:
:Intestinal and human milk microbiota studies during infancy have shown variations according to geographical location, delivery mode, gestational age, and mother-related factors during pregnancy. In this study, we performed metagenomic mycobiota analyses of 44 transient and mature human milk among five different groups: mothers of normal spontaneous delivery-term (NS-T), caesarean delivery-term (CS-T), premature (PT), small for gestational age (SGA), and large for gestational age (LGA) infants. Fungi were detected in 80 out of the 88 samples. Regarding the number of observed fungal species, the NS-T group was more homogeneous (less variable) comparing the other groups (P<0.05). In the transient human milk samples, the most abundant species were Saccharomyces cerevisiae (33.3%) and Aspergillus glaucus (27.4%). While A. glaucus (33.7%) was second most abundant species in mature milk, S. cerevisiae disappeared (P<0.01) and Penicillium rubens became the most abundant species (35.5%) (P<0.05). Among the NS-T group, the most abundant species was Malassezia globosa in both transient and mature milk. In contrast, S. cerevisiae was the most abundant species in transient human milk (45.0%) in the CS-T group, but it disappeared in mature milk (P<0.01). In transient milk, M. globosa was only represented 6.0-9.0% of taxa in the PT, SGA, and LGA groups (P<0.05). In transient and mature milk in the PT, SGA and LGA groups, the most abundant species were A. glaucus and P. rubens. In mature milk samples, P. rubens is more abundant in CS-T group, PT group and LGA group, than the NS-T groups (P<0.05 for all). Although fungi constitute only a very small part of the human milk microbiome, we observed some changes that the human milk mycobiota composition varies in caesarean delivery, premature, SGA and LGA groups, comparing the normal spontaneous delivery, as well as differences between transient and mature human milk.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Dinleyici M,Pérez-Brocal V,Arslanoglu S,Aydemir O,Ozumut SS,Tekin N,Vandenplas Y,Moya A,Dinleyici ECdoi
10.3920/BM2019.0158subject
Has Abstractpub_date
2020-03-27 00:00:00pages
151-162issue
2eissn
1876-2883issn
1876-2891journal_volume
11pub_type
杂志文章abstract::The oral administration of Enterococcus faecium EF1 to new-born suckling and weaning piglets along with their growth performances and intestinal microbiota was investigated in this study. Twenty-four new-born piglets were initially divided into 2 groups. The probiotics group received 2 ml of 10% sterilised skimmed mil...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2015.0099
更新日期:2016-09-01 00:00:00
abstract::There are numerorus published and ongoing experimental/clinical studies about probiotics and prebiotics, intestinal microbiota and nutrition. Three years ago, at the first International Symposium of Probiotics Prebiotics in Paediatrics in Istanbul (2012) we highlighted the 'paediatric perspective' on these issues and ...
journal_title:Beneficial microbes
pub_type:
doi:10.3920/BM2014.x002
更新日期:2015-01-01 00:00:00
abstract::The gut is hypothesised to play an important role in the development and progression of sepsis. It is however unknown whether the gut microbiome and the gut barrier function is already altered early in sepsis development and whether it is possible to modulate the microbiome in early sepsis. Therefore, a randomised, do...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2018.0067
更新日期:2019-04-19 00:00:00
abstract::During the last years, the application of probiotics in gynaecological clinical practice has gained increasing relevance regarding therapy and prevention. This trend has also provoked the need for having tailored pharmaceutical preparations containing powerful microbial strains with defined properties. For the develop...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0069
更新日期:2014-09-01 00:00:00
abstract::Gut bacteria influence host anatomy and physiology. It has been proposed that bacterial metabolites including polyamines are responsible for intestinal maturation and mucosal growth. We have hypothesised that bacterially produced polyamines act as trophic factors and thereby influence large intestinal crypt depth and ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0047
更新日期:2013-09-01 00:00:00
abstract::Vaginal lactobacilli offer protection against microbiota imbalance and genitourinary tract infections. We compared vaginal lactobacilli in 50 Estonian women of child-bearing age applying culture-based methods, quantitative PCR and next-generation sequencing (NGS). The culture-based methods found three different lactob...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0154
更新日期:2015-01-01 00:00:00
abstract::Necrotising enterocolitis (NEC) is associated with inflammatory responses and barrier dysfunction in the gut. In this study, we investigated the effect of Bifidobacterium breve M-16V on factors related to NEC development using an experimental rat model. Caesarean-sectioned rats were given formula milk with or without ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0035
更新日期:2016-02-01 00:00:00
abstract::The objective of the study was to isolate potential probiotic lactobacilli from Kimere, a pearl millet dough prepared in the Mbeere community of Kenya, East Africa, by fermentation for 18-24 hours. Kimere samples, collected from 11 different homesteads in Mbeere, showed average pH values of 3.63±0.29. Counts of presum...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2010.0019
更新日期:2010-09-01 00:00:00
abstract::Hypercholesterolemia is a main risk factor of cardiovascular disease. Probiotics are a safe approach to reduce elevated cholesterol without any deleterious effect to human health. Saccharomyces boulardii CNCM I-745 probiotic properties are well documented in a context of intestinal dysbiosis. Recent in vitro and precl...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2018.0134
更新日期:2019-05-28 00:00:00
abstract::Ulcerative colitis is a type of chronic inflammation present in the intestines for which the aetiology is not yet clear. The current therapies for ulcerative colitis cannot be considered to be long-term management strategies due to their significant side effects. Therefore, it is essential to identify an alternative t...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0035
更新日期:2018-09-18 00:00:00
abstract::There is growing interest in the use of probiotic lactic acid bacteria (LAB) for prevention of hypercholesterolaemia. This study assessed the cholesterol lowering ability of Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in growth media. Both LAB yielded >98% (39.2 μg/ml) cholesterol lowering in growt...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0048
更新日期:2017-02-07 00:00:00
abstract::The yoghurt bacteria, Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus, are alleged to have beneficial effects on human health. The objective of this study was to characterise growth, biochemical activity and competitive behaviour of these two bacteria in vitro and in vivo. S. thermophilus LMD-...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0012
更新日期:2012-09-01 00:00:00
abstract::The current leading view is that functionality and not phylotype is the most important determinant for the services provided by the gut microbiota. Here we present an alternative opinion, advocating the importance of phylotype in addition to function. We believe the literature is misled by technical artifacts in defin...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0016
更新日期:2013-09-01 00:00:00
abstract::Many studies have highlighted the immunomodulatory properties of the probiotic strain Lactobacillus casei BL23. Recently, we demonstrated the ability of this strain to modulate the Th2-oriented immune response in a mouse model of cow's milk allergy based on the induction of a Th17-biased immune response. The probiotic...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0174
更新日期:2017-05-30 00:00:00
abstract::The mechanism of neurodegeneration in Parkinson's disease (PD) remains unknown but it has been hypothesised that the intestinal tract could be an initiating and contributing factor to the neurodegenerative processes. In PD patients as well as in animal models for PD, alpha-synuclein-positive enteric neurons in the col...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0202
更新日期:2018-09-18 00:00:00
abstract::Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain, isolated recently from feta-type cheese. Its probiotic potential has been demonstrated in a series of established in vitro tests. Moreover, incorporation of L. paracasei K5 as starter culture offered organoleptic and technological advantages to novel f...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0183
更新日期:2018-12-07 00:00:00
abstract::Lactic acid bacteria, such as those of the Lactobacillus genus, naturally reside within the microbiota of the human body and have long been used as starter cultures and probiotic enhancers in fermented foods, such as fermented drinks, yoghurts and cheeses. Many of the beneficial qualities of these bacteria have tradit...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2014.0117
更新日期:2015-01-01 00:00:00
abstract::This study aimed to systematically evaluate safety of probiotics and synbiotics in immune compromised adults (≥18 years). Safety was analysed using the Common Terminology Clinical Adverse Events (CTCAE version 4.0) classification, thereby providing an update on previous reports using the most recent available clinical...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0079
更新日期:2015-03-01 00:00:00
abstract::Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be in...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0044
更新日期:2020-10-12 00:00:00
abstract::Bifidobacterium bifidum 791 (commercially available as B. bifidum BIM B-733D) cell-surface biopolymers (BPs) interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti TPO and anti Tg, respectively). BPanti-TPO and BPanti-Tg were isolated from the soluble fraction of B. ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0015
更新日期:2013-12-01 00:00:00
abstract::Few studies have examined the effects of smoking habit, the frequency of alcohol drinking, exercise, and fermented milk consumption on defecatory symptoms and gut microbiota composition, and particularly their interactive effects. We examined the effect of these lifestyle factors on bowel movements and gut microbiota ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0057
更新日期:2019-12-09 00:00:00
abstract::The gut microbiota plays a crucial role in gastrointestinal health. Current use of probiotics is aimed at modulating the bacterial gut composition to alleviate specific diseases. The safety and tolerance of three probiotic strains (Bifidobacterium longum subsp. infantis R0033, Lactobacillus helveticus R0052 and Bifido...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2017.0132
更新日期:2018-06-15 00:00:00
abstract::Over the past decade it has become clear that probiotic and commensal interactions with mucosal dendritic cells in the lamina propria or epithelial cells lining the mucosa can modulate specific functions of the mucosal immune system. Innate pattern-recognition receptors such as TLRs, NLRs and CLRs play a crucial role ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0029
更新日期:2010-11-01 00:00:00
abstract::Dysbiosis may contribute to constipation and its symptoms, therefore probiotic administration could improve significantly gut health and functions. The aim of the study was to investigate the effects of a long-lasting administration of Lactobacillus reuteri DSM 17938 (LR DSM 17938) on symptoms and quality of life (QoL...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2017.0049
更新日期:2018-01-29 00:00:00
abstract::The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2011.0020
更新日期:2011-12-01 00:00:00
abstract::Knee osteoarthritis (OA) treatment is challenging due to inefficacy and adverse effects of current medications. Probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including OA. We aimed to investigate the effect of probiotic L...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2016.0207
更新日期:2017-10-13 00:00:00
abstract::Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim o...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0021
更新日期:2012-12-01 00:00:00
abstract::Ingestion of milks fermented by Lactobacillus strains showing probiotic properties is an important tool to maintain gastrointestinal health. In this study, Lactobacillus rhamnosus D1 and Lactobacillus plantarum B7, isolated from Brazilian artisanal cheese, were used as starters for the functional fermented milks to as...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0163
更新日期:2017-08-24 00:00:00
abstract::Little is known about the prevalence of persistent human infections by nontyphoidal Salmonella (NTS). Recently published study results indicate that a small fraction (at least 2.2%) of NTS-infected patients continue to shed Salmonella for an extended period of time (up to years). Despite the recommendation not to use ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2018.0080
更新日期:2019-03-13 00:00:00
abstract::Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria. It is associated with increased risk for urogenital infections and abortion. In this study we assessed the effect of a yoghurt drink containing Lactobacillus strains on BV. The strains had been is...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2017.0018
更新日期:2018-01-29 00:00:00