Functional Mapping for Glioma Surgery: A Propensity-Matched Analysis of Outcomes and Cost.

Abstract:

OBJECTIVE:To compare clinical outcomes and payments between glioma resections with and without functional mapping. METHODS:The Thomas Reuters MarketScan national longitudinal database was used to identify patients undergoing resection of supratentorial primary malignant glioma with or without functional mapping between 2007 and 2016. Patients were stratified into mapped and unmapped (conventional) groups and subsequently propensity-matched based on demographics, clinical comorbidities, and surgical characteristics (i.e., use of stereotactic navigation, microscope, and intratumoral chemotherapy). Outcomes and charges were compared between matched groups using bivariate analyses. RESULTS:A total of 14,037 patients were identified, of whom 796 (6.0%) received functional mapping. Propensity matching (1:1) resulted in 796 mapped patients and 796 propensity-matched controls. Thirty-day postoperative rates of new-onset seizures, cerebral edema, hemorrhage, and neurologic deficits were significantly lower for the functional mapping group (all P < 0.05). Functional mapping was also associated with shorter hospital length of stay (P = 0.0144), lower 30-day rates of emergency department visits (P = 0.0001), and fewer reoperations (P = 0.0068). Total costs of initial admission were not significantly different between groups. CONCLUSIONS:Intraoperative functional mapping during glioma resection was associated with decreased complications, reoperations, emergency department visits, and shorter lengths of stay. Furthermore, total charges of mapped resections were not significantly different from those of conventional resections. These findings support the usefulness of functional mapping for resection of supratentorial primary malignant gliomas.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Pendharkar AV,Rezaii PG,Ho AL,Sussman ES,Li G,Desai AM

doi

10.1016/j.wneu.2020.01.197

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

e328-e335

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(20)30215-1

journal_volume

137

pub_type

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