当前位置： SCI文献检索 > ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION期刊下所有文献 > Isotopic Scintigraphy Coupled With Computed Tomography for the Investigation of Intrathecal Baclofen Device Malfunction.

Isotopic Scintigraphy Coupled With Computed Tomography for the Investigation of Intrathecal Baclofen Device Malfunction.

Abstract：

OBJECTIVE:To assess the potential use of indium-111 diethylenetriamine pentaacetic acid ((111)In-DTPA) scintigraphy coupled with computed tomography (CT) for the investigation of intrathecal baclofen (ITB) device malfunction. DESIGN:Retrospective study of a case series of patients. SETTING:Neurosurgical and physical and rehabilitation medicine departments. PARTICIPANTS:Patients (N=7) with reduced ITB effectiveness in whom prior conventional radiographs were inconclusive. INTERVENTION:Nine (111)In-DTPA scintigraphic studies and 8 CT scans. Planar acquisitions were followed by tomoscintigraphy combined with CT. MAIN OUTCOME MEASURE:Progression of the radiotracer in the pump, catheters, and in the subarachnoid space. RESULTS:In 7 cases, scintigraphy coupled with CT showed leakage behind the pump, lack of activity outside the pump reservoir, abrupt interruption of activity in the catheter, or abnormal distribution of the radiotracer, thus demonstrating that the drug did not reach its target. Surgical revision confirmed these findings in 5 cases. In 1 case, combined imagery ruled out device dysfunction. In the remaining case, only planar acquisitions were performed, showing correct diffusion of the radiotracer. CONCLUSIONS:The combination of scintigraphy and CT provides simultaneous functional and anatomic imagery of the device. The slow infusion of the radioisotope mimics the diffusion of baclofen, and this could be a useful method to explore intrathecal device malfunction. Further studies are required to compare scintigraphy coupled with CT, to radiopaque injection followed by fluoroscopy or CT.

journal_name

Arch Phys Med Rehabil

journal_title

Archives of physical medicine and rehabilitation

authors

Frémondière F,Lacoeuille F,Sher A,Couturier O,Menei P,Richard I,Dinomais M

doi

10.1016/j.apmr.2015.10.101

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

646-649

issue

4

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(15)01409-4

journal_volume

97

pub_type

杂志文章

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