Abstract:
:Retrotransposons are activated as organisms age, based on work from several model systems. Since these mobile DNA elements can promote genome instability, this has raised the possibility that they can contribute to loss of cellular function with age. Many questions remain to be addressed about the relationship between retrotransposons and aging, so it is unclear if changes in their activity will be found to contribute to aging or to be a consequence of aging. A few broad perspectives are presented regarding how continued work on these elements could provide important insights into the aging process, regardless of whether their mobility is ultimately found to significantly contribute to reduced lifespan and healthspan.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Maxwell PHdoi
10.1007/s00294-015-0538-2subject
Has Abstractpub_date
2016-05-01 00:00:00pages
277-82issue
2eissn
0172-8083issn
1432-0983pii
10.1007/s00294-015-0538-2journal_volume
62pub_type
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