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Long-term Outcomes Associated With Total Arterial Revascularization vs Non-Total Arterial Revascularization.

Abstract：

Importance:The optimal conduits for coronary artery bypass grafting (CABG) remain controversial in multivessel coronary artery disease. Objective:To compare the long-term clinical outcomes of total arterial revascularization (TAR) vs non-TAR (CABG with at least 1 arterial and 1 saphenous vein graft) in a multicenter population-based study. Design, Setting, and Participants:This multicenter population-based cohort study using propensity score matching took place from October 2008 to March 2017 in Ontario, Canada, with a mean and maximum follow-up of 4.6 and 9.0 years, respectively. Individuals with primary isolated CABG were identified, with at least 1 arterial graft. Exclusion criteria were individuals from out of province and younger than 18 years. Patients undergoing a cardiac reoperation or those in cardiogenic shock were also excluded because these conditions would potentially bias the surgeon toward not performing TAR. Analysis began April 2019. Exposures:Total arterial revascularization. Main Outcomes and Measures:Primary outcome was time to first event of a composite of death, myocardial infarction, stroke, or repeated revascularization (major adverse cardiac and cerebrovascular events). Secondary outcomes included the individual components of the primary outcome. Results:Of 49 404 individuals with primary isolated CABG, 2433 (4.9%) received TAR, with the total number of bypasses being 2, 3, and 4 or more vessels in 1521 (62.5%), 865 (35.6%), and 47 individuals (1.9%), respectively. The mean (SD) age was 61.2 (10.4) years and 1983 (81.5%) were men. After propensity score matching, 2132 patient pairs were formed, with equal total number of bypasses (mean [SD], 2.4 [0.5]) but with more arterial grafts in the TAR group (mean [SD], 2.4 [0.5] vs 1.2 [0.4]; P < .01). In-hospital death (15 [0.7%] vs 21 [1.0%]; P = .32) did not differ between TAR vs non-TAR groups after propensity score matching. Throughout 8 years, TAR was associated with improved freedom from major adverse cardiac and cerebrovascular events (hazard ratio, 0.78; 95% CI, 0.68-0.89), death (hazard ratio, 0.80; 95% CI, 0.66-0.97), and myocardial infarction (hazard ratio, 0.69; 95% CI, 0.51-0.92). There was no difference in stroke and repeated revascularization. Conclusions and Relevance:Total arterial revascularization was associated with improved long-term freedom from major adverse cardiac and cerebrovascular events, death, and myocardial infarction and may be the procedure of choice for patients with reasonable life expectancy requiring CABG.

journal_name

JAMA Cardiol

journal_title

JAMA cardiology

authors

Rocha RV,Tam DY,Karkhanis R,Wang X,Austin PC,Ko DT,Gaudino M,Royse A,Fremes SE

doi

10.1001/jamacardio.2019.6104

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

507-514

issue

eissn

2380-6583

issn

2380-6591

pii

2761528

journal_volume

pub_type

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Long-term Outcomes Associated With Total Arterial Revascularization vs Non-Total Arterial Revascularization.