Abstract:
:Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million people worldwide. In this review, AD pathology and the development of novel therapeutic agents targeting AD were fully discussed. In particular, common approaches to prevent Aβ production and/or accumulation in the brain including α-secretase activators, specific γ-secretase modulators and small molecules BACE1 inhibitors were reviewed. Additionally, natural-origin bioactive compounds that provide AD therapeutic advances have been introduced. Considering AD is a multifactorial disease, the therapeutic potential of diverse multi target-directed ligands (MTDLs) that combine the efficacy of cholinesterase (ChE) inhibitors, MAO (monoamine oxidase) inhibitors, BACE1 inhibitors, phosphodiesterase 4D (PDE4D) inhibitors, for the treatment of AD are also reviewed. This article also highlights descriptions on the regulator of serotonin receptor (5-HT), metal chelators, anti-aggregants, antioxidants and neuroprotective agents targeting AD. Finally, current computational methods for evaluating the structure-activity relationships (SAR) and virtual screening (VS) of AD drugs are discussed and evaluated.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Iraji A,Khoshneviszadeh M,Firuzi O,Khoshneviszadeh M,Edraki Ndoi
10.1016/j.bioorg.2020.103649subject
Has Abstractpub_date
2020-04-01 00:00:00pages
103649eissn
0045-2068issn
1090-2120pii
S0045-2068(19)31715-8journal_volume
97pub_type
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journal_title:Bioorganic chemistry
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pub_type: 杂志文章
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
doi:10.1016/j.bioorg.2017.07.017
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journal_title:Bioorganic chemistry
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doi:10.1016/j.bioorg.2017.01.020
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pub_type: 杂志文章
doi:10.1016/j.bioorg.2019.103242
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
doi:10.1016/j.bioorg.2020.104276
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
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journal_title:Bioorganic chemistry
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
doi:10.1016/j.bioorg.2018.01.020
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journal_title:Bioorganic chemistry
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doi:10.1016/j.bioorg.2006.11.006
更新日期:2007-04-01 00:00:00
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
doi:10.1016/j.bioorg.2018.07.022
更新日期:2018-10-01 00:00:00
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Bioorganic chemistry
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00