Current concepts in proteinuria.

Abstract:

:Proteinuria, long recognized as a sign of renal disease, is a common laboratory abnormality in children and adults. Proteinuria may be transient or persistent; when persistent, the cause must be determined. Proteinuria may be primarily glomerular or tubular in origin. Glomerular proteinuria is usually an important concern. Tubular proteinuria often indicates the presence of tubulointerstitial or obstructive renal disease. Screening tests are available to detect albumin (the major protein in glomerular proteinuria), but there are no simple tests for immunoglobulin light chains and low-molecular-mass proteins, which predominate in overflow proteinuria and tubular proteinuria. These small proteins can only be detected by more sophisticated assays such as electrophoresis, isoelectric focusing, and chromatography. The association of glomerular and tubular types of proteinuria with specific disorders is reviewed in this paper, and current concepts in laboratory methodology for the study of proteinuria are summarized.

journal_name

Clin Chem

journal_title

Clinical chemistry

authors

Waller KV,Ward KM,Mahan JD,Wismatt DK

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

755-65

issue

5

eissn

0009-9147

issn

1530-8561

journal_volume

35

pub_type

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