Abstract:
Background:Variceal upper gastrointestinal bleeding (UGIB) is common in sub-Saharan Africa (SSA). However, poor access to endoscopy services precludes the diagnosis of varices. Objectives:We determined the diagnostic accuracy of routine clinical findings for detection of esophageal varices among patients with UGIB in rural SSA where schistosomiasis is endemic. Methods:We studied patients with a history of UGIB. The index tests included routine clinical findings and the reference test was diagnostic endoscopy. Multivariable regression with post-estimation provided measures of association and diagnostic accuracy. Results:We studied 107 participants with UGIB and 21% had active bleeding. One hundred and three (96%) had liver disease and 86(80%) varices. Factors associated with varices (p-value <0.05) were ≥ 4 lifetime episodes of UGIB, prior blood transfusion, splenomegaly, liver fibrosis, thrombocytopenia, platelet count spleen diameter ratio <909, and a dilated portal vein. Two models showed an overall diagnostic accuracy of > 90% in detection of varices with a number needed to misdiagnose of 13(number of patients who needed to be tested in order for one to be misdiagnosed by the test). Conclusion:Where access to endoscopy is limited, routine clinical findings could improve the diagnosis of patients with UGIB in Africa. :The diagnostic accuracy of routine clinical findings for detection of esophageal varices in rural sub-Saharan Africa where schistosomiasis is endemic.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Opio CK,Rejani L,Kazibwe F,Ocama Pdoi
10.4314/ahs.v19i4.46subject
Has Abstractpub_date
2019-12-01 00:00:00pages
3225-3234issue
4eissn
1680-6905issn
1729-0503pii
jAFHS.v19.i4.pg3225journal_volume
19pub_type
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