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Alzheimer's Disease and Vascular Aging: JACC Focus Seminar.

Abstract：

:Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, age-related vascular changes accompany or even precede the development of Alzheimer's pathology, raising the possibility that they may have a pathogenic role. This review provides an appraisal of the alterations in cerebral and systemic vasculature, the heart, and hemostasis that occur in Alzheimer's disease and their relationships to cognitive impairment. Although the molecular pathogenesis of these alterations remains to be defined, amyloid-β is a likely contributor in the brain as in the heart. Collectively, the evidence suggests that vascular pathology is a likely pathogenic contributor to age-related dementia, including Alzheimer's disease, inextricably linked to disease onset and progression. Consequently, the contribution of vascular factors should be considered in preventive, diagnostic, and therapeutic approaches to address one of the major health challenges of our time.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Cortes-Canteli M,Iadecola C

doi

10.1016/j.jacc.2019.10.062

subject

Has Abstract

pub_date

2020-03-03 00:00:00

pages

942-951

issue

8

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(20)30056-5

journal_volume

75

pub_type

杂志文章,评审

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