Atopic Dermatitis: Update on Pathogenesis and Therapy.

Abstract:

:Atopic dermatitis (AD) is the most common inflammatory skin condition in pediatric patients. AD has long been associated with comorbidities including food allergies, asthma, and allergic rhinitis, but recent literature has expanded this list to include attention-deficit/hyperactivity disorder and depression. AD has tremendous impact on quality of life for both affected children and their families. Improved understanding of AD pathogenesis, particularly regarding skin barrier dysfunction, the role of the cutaneous microbiome, and immune dysregulation, has spawned exciting new therapeutic directions. Although good skin care and appropriate use of topical corticosteroids remain first-line treatment, more precisely targeted treatments hold great promise. A recently approved topical phosphodiesterase inhibitor, crisaborole, and a subcutaneously administered interleukin-4/interleukin-13 blocker, dupilumab, are the first of what will likely be many new treatment options for patients with AD. [Pediatr Ann. 2020;49(3):e140-e146.].

journal_name

Pediatr Ann

journal_title

Pediatric annals

authors

de la O-Escamilla NO,Sidbury R

doi

10.3928/19382359-20200217-01

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

e140-e146

issue

3

eissn

0090-4481

issn

1938-2359

journal_volume

49

pub_type

杂志文章,评审
  • International child health.

    abstract::It is our hope that this issue of Pediatric Annals will stimulate among readers a desire to learn more about the difficult challenges faced by our colleagues who live and work in developing countries. They do so much with so little, and their dedication to their work is an inspiration to us all. Armed with such inform...

    journal_title:Pediatric annals

    pub_type: 社论

    doi:10.3928/0090-4481-20041001-04

    authors: Staton DM,Harding MH

    更新日期:2004-10-01 00:00:00

  • A critical evaluation of bronchial hygiene in pediatric pulmonary disease.

    abstract::The variables inherent in analyzing the effectiveness of modalities used to achieve bronchial hygiene are numerous. Treatments may be given in a variety of settings, including intensive-care units, pediatric wards, respiratiory therapy departments, physical therapy departments, chronic-care hospitals, special educatio...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:

    authors: Holsclaw DS,Tecklin JS

    更新日期:1977-08-01 00:00:00

  • Respiratory distress.

    abstract::Preparation for pediatric pulmonary emergencies in the office setting includes adequate training for all medical staff, properly sized and working equipment, and medications to help alleviate respiratory distress when indicated. Status asthmaticus, viral bronchiolitis, and croup account for the vast majority of respir...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/0090-4481-20051101-12

    authors: Fallot A

    更新日期:2005-11-01 00:00:00

  • Prevention of meningococcal infections in the first 2 years of life.

    abstract::The spectrum of disease caused by Neisseria meningitidis includes bacteremia, fulminant sepsis (meningococcemia), meningitis, and pneumonia. The incidence of meningococcal infection has long been higher in infancy than adolescents or adults older than 65 years (a third group with an increased risk based on age). Five ...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/00904481-20130723-11

    authors: Woods CR

    更新日期:2013-08-01 00:00:00

  • Clinical characteristics and efficacious treatment of posttraumatic stress disorder in children and adolescents.

    abstract::Children in the United States are exposed to a variety of traumatic events. Psychosocial sequelae to these events vary in their nature and severity. PTSD is a common, debilitating response to traumatic events that may alter the normal developmental course for children. Risk and protective factors in the development of...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/0090-4481-20050201-13

    authors: Brown EJ

    更新日期:2005-02-01 00:00:00

  • Taking a pediatric sleep history.

    abstract::Sleep problems in children are common, can be persistent and recurrent, can lead to significant health issues, and usually affect other family members as well as the child. There is an AAP guideline to at least screen for snoring. Sleep-deprived children often present with different symptoms than sleep-deprived adults...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/00904481-20080701-02

    authors: Chamness JA

    更新日期:2008-07-01 00:00:00

  • Practical management of eosinophilic esophagitis.

    abstract::CME EDUCATIONAL OBJECTIVES 1. Determine the clinical presentation and diagnostic criteria for eosinophilic esophagitis in children. 2. Discuss the three major treatment strategies for eosinophilic esophagitis. 3. Provide key strategies for practical identification and management of eosinophilic esophagitis in children...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/00904481-20130619-10

    authors: Davis CM

    更新日期:2013-07-01 00:00:00

  • Pediatric upper-extremity fractures.

    abstract::Upper-extremity fractures account for more than half of childhood bony injuries. The frequency of injury increases with increasing mobility. The most common mechanism is a fall on an outstretched hand while playing. Optimal management requires knowledge of the normal anatomy and variants unique to pediatric bones. The...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/00904481-20140417-12

    authors: Arora R,Fichadia U,Hartwig E,Kannikeswaran N

    更新日期:2014-05-01 00:00:00

  • Physician handling of prescription stimulants.

    abstract::Good medical practices can significantly reduce the possibility of diversion and misuse of the stimulants commonly prescribed to treat ADHD. While the problems of misuse and abuse are real, they should not become a barrier to appropriate use of these medicines, which are safe and effective for the large majority of pa...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/0090-4481-20060801-08

    authors: Croft HA

    更新日期:2006-08-01 00:00:00

  • Physical activity considerations in children and adolescents with viral infections.

    abstract::Practitioners involved with the medical care of active children often are called on for advice regarding physical activity recommendations in children and adolescents who are ill. This article has covered many general and specific guidelines to be considered when counseling children and their parents. Recommendations ...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/0090-4481-19961001-11

    authors: Noffsinger J

    更新日期:1996-10-01 00:00:00

  • The pediatric acute scrotum.

    abstract::The pediatric acute scrotum can be a diagnostic dilemma. The history, physical examination, and appropriate tests are important. The correct diagnosis will be arrived at if the systematic approach is remembered (Figure 14). In cases where testicular torsion cannot be ruled out (such as an epididymitis or torsion of th...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/0090-4481-19890301-10

    authors: Hermann D

    更新日期:1989-03-01 00:00:00

  • Cardiac emergencies in children.

    abstract::Pediatric cardiac emergencies require very specific treatment in the emergency room setting. Considering the possibility of a cardiac problem as the cause for the presenting symptoms is the initial step in successful management. Many patients present with what is initially considered a primary pulmonary disorder such ...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/0090-4481-19960601-09

    authors: Schamberger MS

    更新日期:1996-06-01 00:00:00

  • A Phenotypic Female Adolescent with Primary Amenorrhea and Dysmorphic Features.

    abstract::We report on a case of a 14-year-old phenotypic female with a microdeletion at 13q31.1-q31.3, dysmorphic facial and limb features, and neurologic symptoms. She presented to her pediatrician with concerns for delayed puberty, and laboratory analysis revealed hypergonadotropic hypogonadism. She was found to have an XY k...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/19382359-20191118-02

    authors: Kanabolo D,Rodriguez J,Waggoner D,Tucker S,Deplewski D,Kaumeyer B,Lastra RR,Gundeti M

    更新日期:2019-12-01 00:00:00

  • Exercise-Induced Dyspnea in Children and Adolescents: Differential Diagnosis.

    abstract::Exercise-induced dyspnea in children and adolescents can occur for many reasons. Although asthma is the common cause, failure to prevent exercise-induced asthma by pretreatment with a bronchodilator, such as albuterol, indicates that other etiologies should be considered. Other causes of exercise-induced dyspnea inclu...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/19382359-20190219-02

    authors: Bhatia R,Abu-Hasan M,Weinberger M

    更新日期:2019-03-01 00:00:00

  • Uncommon Neonatal Skin Lesions.

    abstract::Certain rashes and cutaneous lesions in a newborn can be clues to more concerning diseases and conditions if recognized and evaluated promptly. Langerhans cell histiocytosis, cutaneous forms of cancer (such as leukemia cutis, neuroblastoma, and rhabdomyosarcoma), developmental abnormalities such as neural tube or spin...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/19382359-20181212-02

    authors: Manning JR,Lee DH

    更新日期:2019-01-01 00:00:00

  • Tic disorders.

    abstract::This article has provided an approach to patients who present with Tourette's syndrome or other tic disorders. The goals are to clarify each of the problems, to determine whether the major source of distress is related to tics or associated behaviors, and to develop an individualized multimodal treatment program. A va...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/0090-4481-19930101-06

    authors: Singer HS

    更新日期:1993-01-01 00:00:00

  • A 9-month-old boy with right-hand preference.

    abstract::We present a case of a 9-month-old boy with a history of unequal hand movements, right-hand preference on physical examination, and cortical dysplasia on brain magnetic resonance imaging who was eventually diagnosed with cerebral palsy (CP). Although spasticity involving one or more limbs is the most common neurologic...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/00904481-20150313-09

    authors: Kastner K,Rust L,Kelley K,Msall M,Hageman JR

    更新日期:2015-03-01 00:00:00

  • Congenital Hyperinsulinism.

    abstract::Congenital hyperinsulinism is a rare disorder that commonly presents in the immediate postnatal period as persistent hypoglycemia. The condition is frequently resistant to medical therapies, and the genetic mutations implicated in the disorder can be predictive of response to therapy. Evaluation of hypoglycemia in the...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/19382359-20171020-01

    authors: Minakova E,Chu A

    更新日期:2017-11-01 00:00:00

  • An algorithm for pediatric enteral alimentation.

    abstract::Many of the metabolic and gastrointestinal complications that occur when patients receive tube feedings result from improper selection or administration of the formula. An algorithm, available tables of formula composition, and adequate flowsheets for recording clinical information that can be adapted to individual in...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/0090-4481-19870301-08

    authors: Wilson SE,Dietz WH Jr,Grand RJ

    更新日期:1987-03-01 00:00:00

  • Pediatric chronic rhinosinusitis.

    abstract::Pediatric chronic rhinosinusitis is a multifactorial inflammatory and infectious disorder. It likely reflects a dysfunction at the site of the interaction between host and environmental factors in the nose and sinuses. Our limited understanding of this common childhood disease makes it difficult to diagnose and to tre...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/00904481-20140723-10

    authors: Silviu-Dan F

    更新日期:2014-08-01 00:00:00

  • Human Papillomavirus and the HPV Vaccine: Where Are We Today?

    abstract::Vaccine discussions are an important part of the general pediatrician's day. The human papillomavirus (HPV) vaccine, in particular, has been slow to gain acceptance by the general public. It has recently gained momentum (both positive and negative) on social media, which has led to an increase in questions and concern...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/19382359-20161216-01

    authors: Khan L

    更新日期:2017-01-01 00:00:00

  • Diagnosis and treatment of polycystic ovarian syndrome and insulin resistance.

    abstract::PCOS is a complex syndrome that includes clinical and biochemical evidence of hyperandrogenism and hyperinsulinism. Adolescents with PCOS are affected by the diagnosis with both short-term and long-term consequences. Adolescents with PCOS report lower self-esteem and quality of life, based on standard assessments, whe...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/0090-4481-20050901-13

    authors: Fleischman A,Mansfield J

    更新日期:2005-09-01 00:00:00

  • Manifestations of food allergy in infants and children.

    abstract::Most adverse reactions to foods are the result of intolerances rather than food allergy. It is important to identify children with potential food allergy as life-threatening, and life-ending reactions can occur. A clear understanding of the manifestations of food allergy caused by both IgE- and non-IgE-related mechani...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/00904481-20080801-05

    authors: Story RE

    更新日期:2008-08-01 00:00:00

  • Viral Hepatitis in Children: A Through E.

    abstract::Hepatitis is defined as inflammation of the liver. This inflammation can be acute and self-limited, chronic (leading to cirrhosis and an increased risk for hepatocellular carcinoma), or fulminant (requiring lifesaving liver transplantation). Although there are many causes of hepatitis, this article focuses on the main...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/19382359-20161114-01

    authors: Chugh A,Maximos M,Perlman M,Gonzalez-Peralta RP

    更新日期:2016-12-01 00:00:00

  • Poliomyelitis prevention in the United States: new recommendations for routine childhood vaccination place greater reliance on inactivated poliovirus vaccine.

    abstract::Until worldwide eradication of poliomyelitis is achieved, vaccination with poliovirus vaccines is the only means for providing population and individual immunity to polioviruses. The ACIP, AAP, and AAFP support the global poliomyelitis eradication initiative, and have recommended a transition policy that will increase...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/0090-4481-19970601-09

    authors: Prevots DR,Strebel PM

    更新日期:1997-06-01 00:00:00

  • Pediatric polysomnography for sleep-disordered breathing prior to tonsillectomy: a guideline review.

    abstract::Snoring and other signs of sleep-disordered breathing (SDB) represent a common management challenge for the pediatrician, pulmonologist, anesthesiologist, and otolaryngologist. In 2011, the American Academy of Otolaryngology-Head and Neck Surgery published a clinical practice guideline for the treatment of patients wi...

    journal_title:Pediatric annals

    pub_type: 杂志文章,评审

    doi:10.3928/00904481-20130924-08

    authors: Walz PC,Schroeder JW Jr

    更新日期:2013-10-01 00:00:00

  • The Safe Environment for Every Kid model: promotion of children's health, development, and safety, and prevention of child neglect.

    abstract::Child neglect is by far the most prevalent form of child maltreatment. There is a need to try to prevent this problem, and pediatric primary care offers an excellent opportunity. This article describes one such approach, the Safe Environment for Every Kid (SEEK) model. SEEK enables practitioners to identify and help a...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/00904481-20141022-11

    authors: Dubowitz H

    更新日期:2014-11-01 00:00:00

  • Prolonged Hospital Discharge for Children with Technology Dependency: A Source of Health Care Disparities.

    abstract::Children with ventilator assistance have been supported in living at home since 1981 when parental advocacy ushered in a change to Medicaid policy. As the population of children who use medical technology such as long-term ventilation increases, we must critically evaluate our systems for preparing families for home l...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/19382359-20170919-01

    authors: Sobotka SA,Agrawal RK,Msall ME

    更新日期:2017-10-01 00:00:00

  • An introduction to the National Committee for Quality Assurance.

    abstract::The corporations that purchase private health benefits and the public payers, Medicare and Medicaid, are insisting increasingly that managed care plans be publicly accountable for the quality of care and service delivered. NCQA has responded to that demand with programs that assess both the organization and operation ...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/0090-4481-19980401-09

    authors: Sennett C

    更新日期:1998-04-01 00:00:00

  • Assessing Readiness for En Pointe in Young Ballet Dancers.

    abstract::Children begin ballet lessons as young as age 2 years. The graceful movements of classical ballet require a combination of artistry, flexibility, and strength to perform. During the training and development of a young ballerina, the transition to dancing en pointe ("on the toes") represents a significant milestone and...

    journal_title:Pediatric annals

    pub_type: 杂志文章

    doi:10.3928/00904481-20151215-01

    authors: Lai JC,Kruse DW

    更新日期:2016-01-01 00:00:00