Plasma Concentrations of Tranexamic Acid in Postpartum Women After Oral Administration.

Abstract:

OBJECTIVE:To evaluate the pharmacokinetics of tranexamic acid after oral administration to postpartum women. METHODS:We conducted a single-center pharmacokinetic study at Teaching Hospital-Jaffna, Sri Lanka, on 12 healthy postpartum women who delivered vaginally. After oral administration of 2 g of immediate-release tranexamic acid 1 hour after delivery, pharmacokinetic parameters were measured on plasma samples at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, and 12 hours. Plasma tranexamic acid concentrations were determined by high-performance liquid chromatography. The outcome measures were maximum observed plasma concentration, time to maximum plasma concentration, time to reach effective plasma concentration, time period effective serum concentration lasted, area under the curve for drug concentration, and half-life of tranexamic acid. RESULTS:The mean maximum observed plasma concentration was 10.06 micrograms/mL (range 8.56-12.22 micrograms/mL). The mean time to maximum plasma concentration was 2.92 hours (range 2.5-3.5 hours). Mean time taken to reach the effective plasma concentration of 5 micrograms/mL and the mean time this concentration lasted were 0.87 hours and 6.73 hours, respectively. Duration for which plasma tranexamic acid concentration remained greater than 5 micrograms/mL was 5.86 hours. Half-life was 1.65 hours. Area under the curve for drug concentration was 49.16 micrograms.h/mL (range 43.75-52.69 micrograms.h/mL). CONCLUSION:Clinically effective plasma concentrations of tranexamic acid in postpartum women may be achieved within 1 hour of oral administration. Given the promising pharmacokinetic properties, we recommend additional studies with larger sample sizes to investigate the potential of oral tranexamic acid for the treatment or prophylaxis of postpartum hemorrhage.

journal_name

Obstet Gynecol

authors

Muhunthan K,Balakumar S,Navaratnaraja TS,Premakrishna S,Arulkumaran S

doi

10.1097/AOG.0000000000003750

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

945-948

issue

4

eissn

0029-7844

issn

1873-233X

pii

00006250-202004000-00023

journal_volume

135

pub_type

临床试验,杂志文章
  • Hydramnios and maternal renal failure: relief with fetal therapy.

    abstract::Hydramnios and maternal renal compromise are described in a singleton pregnancy with a large fetal abdominal cystic mass. Both the hydramnios and the renal failure resolved after percutaneous drainage of the fetal cyst. Rapid reaccumulation of the mass resulted in redrainage and placement of an indwelling cyst/amnioti...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-198409001-00007

    authors: Seeds JW,Cefalo RC,Herbert WN,Bowes WA Jr

    更新日期:1984-09-01 00:00:00

  • Misoprostol compared with laminaria before early second-trimester surgical abortion: a randomized trial.

    abstract:OBJECTIVE:To compare the efficacy and acceptability of same-day misoprostol and overnight laminaria for cervical ripening before early second-trimester surgical abortion. METHODS:We performed a randomized, double-blinded, controlled trial comparing 400 microg of vaginal misoprostol, given 3-4 hours preoperatively, wit...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.AOG.0000168629.17326.00

    authors: Goldberg AB,Drey EA,Whitaker AK,Kang MS,Meckstroth KR,Darney PD

    更新日期:2005-08-01 00:00:00

  • Occult Gynecologic Cancer in Women Undergoing Hysterectomy or Myomectomy for Benign Indications.

    abstract:OBJECTIVE:To estimate the prevalence of corpus uteri, cervix uteri, and ovarian malignancy in women undergoing hysterectomy or myomectomy for presumed benign indications. METHODS:We conducted a secondary analysis of data from the 2014-2015 American College of Surgeons National Surgical Quality Improvement Program. Adu...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/AOG.0000000000002521

    authors: Desai VB,Wright JD,Schwartz PE,Jorgensen EM,Fan L,Litkouhi B,Lin H,Gross CP,Xu X

    更新日期:2018-04-01 00:00:00

  • Osteosarcoma during pregnancy.

    abstract::Four white women who developed osteosarcoma during pregnancy were referred for treatment, 2 prior to delivery and development of metastases, and 2 after delivery and development of metastases. After amputation, these patients received combination chemotherapy with either vincristine-cyclophosphamide or adriamycin-cycl...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Pratt CB,Rivera G,Shanks E

    更新日期:1977-07-01 00:00:00

  • Severe pulmonary hypertension in pregnancy following successful repair of ventricular septal defect in childhood.

    abstract:BACKGROUND:Because of advances in surgical repair, an increasing number of women born with structural cardiac disease now live to reproductive age. Patients treated successfully in childhood are followed for varying periods of time, then may be lost to follow-up or told that no follow-up is necessary because their cond...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Jackson GM,Dildy GA,Varner MW,Clark SL

    更新日期:1993-10-01 00:00:00

  • A simple and sensitive color test for the detection of human chorionic gonadotropin.

    abstract::A simple, rapid, sensitive, and reliable ELISA test for the detection of urinary human chorionic gonadotropin (hCG) has been developed using penicillinase (EC no. 3.5.2.6) as the label and a microtiter ELISA plate as a solid support for antibody. The results of the test is assessed visually for the dark blue that indi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Joshi UM,Roy R,Sheth AR,Shah HP

    更新日期:1981-02-01 00:00:00

  • Comparison of persistent ectopic pregnancy after laparoscopic salpingostomy versus salpingostomy at laparotomy for ectopic pregnancy.

    abstract:OBJECTIVE:To compare persistent ectopic pregnancy after laparoscopic salpingostomy versus salpingostomy at laparotomy for the treatment of intact ampullary ectopic pregnancy. METHODS:We reviewed the medical records of 157 patients who had undergone salpingostomy for intact ampullary ectopic pregnancy at Yale-New Haven...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Seifer DB,Gutmann JN,Grant WD,Kamps CA,DeCherney AH

    更新日期:1993-03-01 00:00:00

  • Risk factors for pelvic organ prolapse repair after hysterectomy.

    abstract:OBJECTIVE:To estimate the incidence and identify the risk factors for pelvic organ prolapse repair after hysterectomy. METHODS:We conducted a case-control study. We identified 6,214 women who underwent hysterectomy in our gynecology department from 1982 to 2002. Cases (n=114) were women who required pelvic organ prola...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000278567.37925.4e

    authors: Dällenbach P,Kaelin-Gambirasio I,Dubuisson JB,Boulvain M

    更新日期:2007-09-01 00:00:00

  • Cortical blindness in severe preeclampsia: computed tomography, magnetic resonance imaging, and single-photon-emission computed tomography findings.

    abstract:BACKGROUND:Cortical blindness is a complication of severe preeclampsia, but it is unclear whether it results from cerebral vasospasm and ischemic injury or vasogenic (hydrostatic) edema due to increased capillary permeability. CASE:Reversible cortical blindness in a 33-year-old gravida 2, para 1, with severe postpartu...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)00878-4

    authors: Apollon KM,Robinson JN,Schwartz RB,Norwitz ER

    更新日期:2000-06-01 00:00:00

  • Unexpected frequency of idiopathic costochondral pain.

    abstract::A study of the records of patients seen in a two-year period in a private gynecologic practice and a one-year period in the emergency department of a general hospital was prompted by the incidence of chest wall pain diagnosed as costochondral pain. The study revealed 76 women in the former practice and 156 men and wom...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Peyton FW

    更新日期:1983-11-01 00:00:00

  • Comparison between urinary 17-ketosteroids and serum androgens in hirsute patients.

    abstract::In order to ascertain the usefulness of urinary 17-ketosteroids (17-KS) in the evaluation of hirsutism, 28 paired determinations of 17-KS and serum androgens were performed in 26 hirsute women before (control) and after (post Dex) 7 days of dexamethasone (Dex) administration. Upper normal control and post Dex urinary ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Maroulis GB,Manlimos FS,Abraham GE

    更新日期:1977-04-01 00:00:00

  • A fetal sacrococcygeal tumor obstructing labor after attempted home confinement.

    abstract::Obstructed labor due to a large sacrococcygeal tumor is reported. A technique of transabdominal intrauterine reduction in the size of the tumor to allow delivery of the infant in satisfactory condition is described. The method and the successful outcome have not previously been reported. It is recommended as a combine...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Edwards WR

    更新日期:1983-03-01 00:00:00

  • Capillary hemangioma of the vagina and urethra in a child: response to short-term steroid therapy.

    abstract::Short-term oral steroid therapy was used to treat a capillary hemangioma of the vagina and urethra in a young child. After 8 weeks of prednisolone therapy (40 mg every other day decreasing to 2.5 mg every other day), vaginal bleeding has not recurred. At 2 years and 8 months, the patient presented with severe hematuri...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Cook CL,Sanfilippo JS,Verdi GD,Pietsch JB

    更新日期:1989-05-01 00:00:00

  • Fetal injury associated with cesarean delivery.

    abstract:OBJECTIVE:To describe the incidence and type of fetal injury identified in women undergoing cesarean delivery. METHODS:Between January 1, 1999, and December 31, 2000, a prospective cohort study of all cesarean deliveries was conducted at 13 university centers. Information regarding maternal and infant outcomes was abs...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.AOG.0000237116.72011.f3

    authors: Alexander JM,Leveno KJ,Hauth J,Landon MB,Thom E,Spong CY,Varner MW,Moawad AH,Caritis SN,Harper M,Wapner RJ,Sorokin Y,Miodovnik M,O'Sullivan MJ,Sibai BM,Langer O,Gabbe SG,National Institute of Child Health and Human Deve

    更新日期:2006-10-01 00:00:00

  • Obstetric admissions to the intensive care unit.

    abstract:OBJECTIVE:To determine whether obstetric admissions to the intensive care unit (ICU) are useful quality-assurance indicators. METHODS:We analyzed retrospectively obstetric ICU admissions at two tertiary care centers from 1991 to 1997. RESULTS:The 131 obstetric admissions represented 0.3% of all deliveries. The majori...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(99)00274-4

    authors: Mahutte NG,Murphy-Kaulbeck L,Le Q,Solomon J,Benjamin A,Boyd ME

    更新日期:1999-08-01 00:00:00

  • Galactography and exfoliative cytology in women with abnormal nipple discharge.

    abstract:OBJECTIVE:To evaluate galactography and cytology in women with nipple discharge without clinical or mammographic evidence of cancer. METHODS:During a 12.5-year period, 384 women (15-85 years, mean age 47.5 +/- 14 years) were referred for galactography and smear cytology for recent onset of spontaneous, non-milky nippl...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)01229-1

    authors: Dinkel HP,Gassel AM,Müller T,Lourens S,Rominger M,Tschammler A

    更新日期:2001-04-01 00:00:00

  • Sexual transmission of Candida.

    abstract::Mycotic cultures of 33 couples, in which the women had a diagnosis of chronic recurrent vulvovaginitis, were prepared from the oral cavity, the rectum, the vagina, and the male ejaculate. Reservoirs of infection were found in the oral cavities of 36% of the couples, the rectum in 33%, and the ejaculate in 15%. Prostat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Horowitz BJ,Edelstein SW,Lippman L

    更新日期:1987-06-01 00:00:00

  • Osteogenesis imperfecta: mode of delivery and neonatal outcome.

    abstract:OBJECTIVE:To evaluate the pregnancy characteristics, methods of delivery, and neonatal outcomes of fetuses affected by osteogenesis imperfecta. METHODS:We reviewed medical records of 1016 individuals whose cells were sent to the University of Washington Collagen Diagnostic Laboratory between 1987 and 1994 for confirma...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)01100-5

    authors: Cubert R,Cheng EY,Mack S,Pepin MG,Byers PH

    更新日期:2001-01-01 00:00:00

  • Enhanced thrombin generation and fibrinolytic activity in normal pregnancy and the puerperium.

    abstract::Blood coagulation and fibrinolytic inhibitors and the balance between and within the two systems were investigated in 26 normal pregnant women during pregnancy and the puerperium. The concentration of the coagulation inhibitors antithrombin and protein C remained within normal levels, whereas the mean level of free pr...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Bremme K,Ostlund E,Almqvist I,Heinonen K,Blombäck M

    更新日期:1992-07-01 00:00:00

  • The "remote control" laparoscopic bag: a simple technique to remove intra-abdominal specimens.

    abstract:BACKGROUND:To facilitate extraction and avoid intra-abdominal spillage during laparoscopic removal of adnexal masses, various designs and sizes of endopouches (bags) have been used. We describe a simple technique using a special laparoscopic bag that requires no additional instruments to hold, open, or close the bag. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Chatzipapas IK,Hart RJ,Magos A

    更新日期:1998-10-01 00:00:00

  • Perinatal infection with Torulopsis glabrata: a case associated with maternal sickle cell anemia.

    abstract::Torulopsis glabrata is a yeast of low virulence and commensal within the female genitourinary tract. The first case of congenital infection with Torulopsis glabrata was reported in 1980. An additional example of perinatal Torulopsis infection which is associated with maternal sickle cell anemia is reported. The most c...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Sander CH,Martin JN,Rogers AL,Barr M Jr,Heidelberger KP

    更新日期:1983-03-01 00:00:00

  • Testosterone-producing solitary ovarian cyst with luteinized stromal-cell hyperplasia.

    abstract:BACKGROUND:Hormone production is a characteristic associated with the presence of solid tumors in the ovary. We present a case of a solitary ovarian cyst producing large amounts of testosterone and presenting with rapid onset of hirsutism. CASE:A woman presented approximately 6 months postpartum with irregular menses ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Goudas VT,Wasty F,Pardanani B,Ying YK

    更新日期:1996-05-01 00:00:00

  • Midtrimester abortion by intraamniotic prostaglandin F2alpha. Safer than saline?

    abstract::Published reports disagree on the risks of intraamniotic prostaglandin F2alpha (PGF2alpha) for midtrimester abortion. To evaluate the safety and efficacy of intraamniotic PGF2alpha, we compared 1241 PGF2alpha and 10,013 saline abortions performed during the 13th to the 24th menstrual week. The results were reported in...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Grimes DA,Schulz KF,Cates W Jr,Tyler CW Jr

    更新日期:1977-05-01 00:00:00

  • Tumor-level serum testosterone associated with human immunodeficiency virus lipodystrophy syndrome.

    abstract:BACKGROUND:Human immunodeficiency virus (HIV) lipodystrophy syndrome consists of insulin resistance, hyperlipidemia, increased waist-to-hip ratios, and relative hyperandrogenemia, which resembles polycystic ovary syndrome. CASE:A 30-year-old HIV-positive multipara with lipodystrophy syndrome had an elevated level of s...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000121832.02536.c3

    authors: Dahan MH,Lyle LN,Wolfsen A,Chang RJ

    更新日期:2004-05-01 00:00:00

  • Transvaginal endoscopic removal of eroded mesh after abdominal sacral colpopexy.

    abstract:BACKGROUND:Abdominal sacral colpopexy with permanent mesh has become the preferred abdominal technique for correcting posthysterectomy vaginal vault prolapse. Although rare, mesh erosion after sacral colpopexy is often challenging to manage. We report on 3 cases of mesh erosion after abdominal sacral colpopexy managed ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000123242.69217.93

    authors: Romero AA,Amundsen CL,Weidner AC,Webster GD

    更新日期:2004-05-01 00:00:00

  • Fetal heart rate patterns and fetal distress in fetuses with congenital anomalies.

    abstract::Over a 3-year period at the Long Beach Women's Hospital, where electronic FHR (fetal heart rate) monitoring was routine, there were 8622 live births, including 41 infants born with major congenital malformations. The neonatal death rate in these malformed infants was 44%; 17 were delivered by cesarean section, 11 of w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Garite TJ,Linzey EM,Freeman RK,Dorchester W

    更新日期:1979-06-01 00:00:00

  • Prevalence of Human Papillomavirus in Self-Collected Cervicovaginal Swabs in Young Women in the United States Between 2003 and 2012.

    abstract:OBJECTIVE:To evaluate whether there was a change in prevalence of human papillomavirus (HPV) in the United States correlated with the introduction of HPV vaccines in both vaccinated and unvaccinated women. METHODS:We performed a retrospective review of prevalence data for women aged 18-29 years living in the United St...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001760

    authors: Tarney CM,Klaric J,Beltran T,Pagan M,Han J

    更新日期:2016-12-01 00:00:00

  • Diagnosis of chlamydial infection in pregnant women using the Testpack Chlamydia diagnostic kit.

    abstract::We compared the performance of Testpack Chlamydia to tissue culture isolation for detection of endocervical chlamydia in an obstetric clinic population at high risk for infection. Among 227 evaluable patients, 30 tissue culture-confirmed chlamydial infections were found (13.2%). The sensitivity, specificity, and posit...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Grossman JH 3rd,Rivlin ME,Morrison JC

    更新日期:1991-05-01 00:00:00

  • Renal cell carcinoma in pregnancy: report of three cases and review of the literature.

    abstract:BACKGROUND:Renal cell carcinoma is a potentially fatal tumor that occasionally presents during pregnancy. Based on our experience with three patients and a review of the recent cases in the literature, we believe there has been a change in presentation of this lesion over that described in previous reviews. CASES:Two ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Smith DP,Goldman SM,Beggs DS,Lanigan PJ

    更新日期:1994-05-01 00:00:00

  • Routine endocrine screening for patients with karyotypically normal spontaneous premature ovarian failure.

    abstract:OBJECTIVE:To evaluate the usefulness of routine screening for other associated autoimmune endocrine disorders in patients with karyotypically normal spontaneous premature ovarian failure. METHODS:One hundred nineteen women with karyotypically normal spontaneous premature ovarian failure (FSH exceeding 40 mIU/mL) who d...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(97)00077-x

    authors: Kim TJ,Anasti JN,Flack MR,Kimzey LM,Defensor RA,Nelson LM

    更新日期:1997-05-01 00:00:00