Cognitive Reserve from the Perspective of Preclinical Alzheimer Disease: 2020 Update.

Abstract:

:The concept of cognitive reserve (CR) was proposed to account for the discrepancy between levels of brain pathologic process or damage and clinical and cognitive function. We provide a detailed review of prospective longitudinal studies that have investigated the interaction between CR and Alzheimer disease (AD) biomarkers on clinical and cognitive outcomes among individuals with normal cognition at baseline. Current evidence is consistent with the view that higher levels of CR are associated with a delay in the onset of symptoms of mild cognitive impairment and that there may be multiple pathways by which CR exerts its protective effects.

journal_name

Clin Geriatr Med

authors

Soldan A,Pettigrew C,Albert M

doi

10.1016/j.cger.2019.11.006

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

247-263

issue

2

eissn

0749-0690

issn

1879-8853

pii

S0749-0690(19)30110-7

journal_volume

36

pub_type

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