In Vitro Inhibitory Effect of Recombinant Human Calprotectin on Nalm6 Leukemia Cell Line.

abstract：:The systematic improvement of methods used for unraveling physiological and pathological role of proteases, as well as for elucidation of relevant hydrolase structures contributes to the progress in the area of new inhibitor-like drugs development. Many of protease inhibitors have entered clinics and are now successfu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Białas A,Kafarski P

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The ratio of live cells to total cells in a sample is a definition for cell viability or cell toxicity. The assessment of the viable cells plays a critical role in all processes of the cell culture workflows. Overall, they are used to evaluate the survival of cells and also to optimize culture ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Nozhat Z,Khalaji MS,Hedayati M,Kia SK

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:Multi-kinase inhibitor sorafenib showed dramatic effects in acute myeloid leukemia (AML) cells harboring fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation. However, FLT3-ITD mutation only occurs in 25% of AML cases. The therapeutic effects of sorafenib in AML patients without FLT3...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yang N,Gu Z,Liu Z,Huang W,Wang S,Wang L,Gao C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Glucosamine is a widely prescribed dietary supplement used in the treatment of osteoarthritis. In the present study, the chemoprotectant ability of glucosamine was evaluated against cisplatin-induced genotoxicity and cytotoxicity in rat bone marrow cells. METHODS:Glucosamine was orally adminis...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cheki M,Jafari S,Najafi M,Mahmoudzadeh A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes lead to tumor formation in cancer stem cells and show drug resistance. Epigenetic modulators and /or t...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Erkisa M,Aztopal N,Erturk E,Ulukaya E,Yilmaz VT,Ari F

更新日期：2020-12-06 00:00:00

abstract：BACKGROUND:The cause of cervical cancer can be traced to Human Papilloma Virus (HPV) along with other, nonviral factors. The uterine cervix is reactive to hormones, and female hormones have been implicated in cervical cancer pathogenesis. Previous studies have indicated that malignant cervical cells tend to lose Estrog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yu P,Wang Y,Li C,Lv L,Wang J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:6-Gingerol (6G) and 6-Shogaol (6S) are the main active components of ginger. 6-Gingerol is known for its anti-metastatic and anti-invasive pharmacological activities on cancer cells, besides, 6-Shogaol also inhibits breast cancer cell invasion. OBJECTIVE:In this study, radioiodination (131I) of 6G and 6S wa...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karatay KB,Kılçar AY,Derviş E,Müftüler FZB

更新日期：2020-01-01 00:00:00

abstract：:Sphingolipids are membrane lipids that play important roles in the regulation of cell functions and homeostasis. Alterations in their metabolism have been associated with several pathologies. For this reason, therapeutic strategies based on the design of small molecules to restore sphingolipid levels to their physiolo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Delgado A,Fabrias G,Bedia C,Casas J,Abad JL

更新日期：2012-05-01 00:00:00

abstract：:Integration of geriatric assessment into cancer clinical practice is strongly needed in squamous cell carcinoma of the head and neck (SCCHN) due to the frequent discrepancy between chronologic and biologic age. Comprehensive Geriatric Assessment (CGA) is a multidimensional assessment tool that examines age-related dom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Perri F,Ionna F,Pavone E,Longo F,Caponigro F

更新日期：2013-11-01 00:00:00

abstract：:Emetine and CGP-74514A have previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic activity was induction of apoptosis. An in vitro hollow fiber mode...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Larsson DE,Hassan SB,Oberg K,Granberg D

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is the collective name for different types of leukemias of myeloid origin affecting blood and bone marrow. The overproduction of immature myeloblasts (white blood cells) is the characteristic feature of AML, thus flooding the bone marrow and reducing its capacity to produce normal bloo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Dogra R,Bhatia R,Shankar R,Bansal P,Rawal RK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy. MYC family oncogenes are amplified and overexpressed in 20% of SCLCs, showing that MYC oncogenes and MYC regulated genes are strong candidates as therapeutic targets for SCLC. c-MYC plays a fundamental role in cancer stem cell properties and ma...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tokgun O,Tokgun PE,Inci K,Akca H

更新日期：2020-01-01 00:00:00

abstract：:Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in cancer, particularly the receptor tyrosine kinases, the intracellular pathways, and the genetic and epigenetic alterations, resulting in an unprecedented surge of novel, targeted therapies and therapeu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yasui H,Imai K

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The 2-amino 1,3,4-thiadiazole framework has attracted considerable interest because of its prevalence in compounds possessing a wide range of pharmacological properties including anticancer/antitumor activities. Though a number of methods have been reported for the synthesis of this class of compounds, some ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Prasad MG,Lakshmi CV,Katari NK,Pal M

更新日期：2020-01-01 00:00:00

abstract：:Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular processes. Deregulation of sphingolipid metabolism is reflected as various pathophysiological conditions including metabolic disorders and several forms of cancer. Ceramides, ceramide-1-phosphate (C1P), glucosyl ceramid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ekiz HA,Baran Y

更新日期：2011-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest types of cancers. Median survival rate is very poor with the currently available chemotherapeutical regimens. Therefore, discovery of new antineoplastic agents against PDA is one of the focused areas of contemporary research. The present study was und...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Goswami A,Shah BA,Batra N,Kumar A,Guru SK,Bhushan S,Malik FA,Joshi A,Singh J

更新日期：2016-01-01 00:00:00

abstract：:Cancer is the main cause of death, so the search for active agents to be used in the therapy of this disease, is necessary. According to studies conducted, substances derived from natural products have shown to be promising in this endeavor. To these researches, one can associate with the aid of computational chemistr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cavalcanti ÉBVS,Félix MB,Scotti L,Scotti MT

更新日期：2019-01-01 00:00:00

abstract：:Evidence supports that a variety of cancers are sparked by the growth of cells that exhibit characteristics of stem cells. Such cancer-initiating cells are capable of populating a tumor with a heterogeneous group of daughter cells while still maintaining the ability to self-renew. Several groups have recently reported...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Murphy SK

更新日期：2010-02-01 00:00:00

abstract：:The study of anticancer properties from natural products has regained popularity as natural molecules provide a high diversity of chemical structures with specific biological and medicinal activity. Based on a documented library of the most common medicinal plants used by the indigenous people of North America, we scr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Benzina S,Harquail J,Jean S,Beauregard AP,Colquhoun CD,Carroll M,Bos A,Gray CA,Robichaud GA

更新日期：2015-01-01 00:00:00

abstract：:The article has been withdrawn at the request of the editor of the journal Anti-Cancer Agents in Medicinal Chemistry. Bentham Science apologizes to the readers of the journal for any inconvenience this may cause. Bentham Science Disclaimer:It is a condition of publication that manuscripts submitted to this journal ha...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ristau BT,Fuller TW,Rios R,Ho C,Tomaszewski JJ

更新日期：2017-11-13 00:00:00

abstract：:Replication fork reversal and restart has gained immense interest as a central response mechanism to replication stress following DNA damage. Although the exact mechanism of fork reversal has not been elucidated precisely, the involvement of diverse pathways and different factors has been demonstrated, which are centr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Jain CK,Mukhopadhyay S,Ganguly A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Functional foods, neutraceuticals and natural antioxidants have established their potential roles in the protection of human health and diseases. Thymoquinone (TQ), the main bioactive component of Nigella sativa seeds (black cumin seeds), a plant derived neutraceutical was used by ancient Egyptians because o...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sundaravadivelu S,Raj SK,Kumar BS,Arumugamand P,Ragunathan PP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrids have attracted the keen attention of researchers to discover their therapeutic capability against cancer. OBJECTIVE:The present study ai...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rizzk YW,El-Deen IM,Mohammed FZ,Abdelhamid MS,Khedr AIM

更新日期：2019-01-01 00:00:00

abstract：:Cancer is the deadliest disease worldwide and the development of safer chemical entities to treat cancer is one of the major challenges of medicinal chemistry. Emergence of new cases every year and development of multiple drug resistance against available molecular entities has turned the focus of researchers towards ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Shukla S,Sood AK,Goyal K,Singh A,Sharma V,Guliya N,Gulati S,Kumar S

更新日期：2020-11-24 00:00:00

abstract：:Reactive oxygen species (ROS) are produced as normal products of cellular metabolism, which are essential for numerous cell biological functions. Due to aberrant metabolism, oncogenic signaling activation and mitochondrial dysfunction, cancer cells generate excessive ROS that cause severe oxidative damage, finally lea...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cheng Y,Qi Y

更新日期：2017-01-01 00:00:00

abstract：:Radiolabelled peptides have shown to be an important class of radiopharmaceuticals for imaging and therapy of malignancies expressing receptors of regulatory peptides. These peptides have high affinity and specificity for their receptors. The majority of these receptors are present at different levels in different tis...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Breeman WA,Kwekkeboom DJ,de Blois E,de Jong M,Visser TJ,Krenning EP

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Colorectal cancer is among the leading causes of death worldwide. The incidence of deaths is expected to be 11.4 million in 2030. OBJECTIVE:We aimed to evaluate the in vitro and in vivo antioxidant and antitumor activities of a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal cancer...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Abdel-Rasol M,El-Beih NM,Yahya SMM,Ismail MA,El-Sayed WM

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Esophageal cancer remains an aggressive disease with poor survival rates. FAK and IGF-1R are two important tyrosine kinases important for cell survival signaling and found to be upregulated in esophageal cancer. Our hypothesis is that a novel small molecule compound that disrupts FAK and IGF-1R protein-pro...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ucar DA,Cox A,He DH,Ostrov DA,Kurenova E,Hochwald SN

更新日期：2011-09-01 00:00:00

abstract：:Glioblastoma Multiforme (GMB) is the most aggressive primary brain tumor with poor survival rates and universal recurrence despite aggressive treatments. Recent research suggested that GBM has multiple glioma cell populations, some of which are organized in a stem cell hierarchical order with different stages of diffe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Alexandru-Abrams D,Jadus MR,Hsu FP,Stathopoulos A,Bota DA

更新日期：2014-01-01 00:00:00

abstract：:The metabolism of alkylating agents is accompanied by the generation of reactive oxygen species. The aim of this study was to treat estrogen receptor-positive and estrogen receptor-negative human breast cancer cells, MCF-7 and MDA-MB-231, respectively, with cisplatin and five different berenil-platinum (II) complexes,...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Agnieszka G,Ewa A,Anna B,Krzysztof B,Monika C,Elżbieta S

更新日期：2014-01-01 00:00:00