Abstract：
:The use of lignocellulosic feedstock for lactic acid production with a difficulty is that the release of inhibitory compounds during the pretreatment process which inhibit the growth of microorganism. Thus we report a novel lactic acid bacterium, Lactobacillus paracasei 7 BL, that has a high tolerance to inhibitors and produced optically pure l-lactic acid after the interruption of ldhD gene. The strain 7 BL fermented glucose efficiently and showed high titer of l-lactic acid (215 g/l) by fed-batch strategy. In addition, 99 g/l of l-lactic acid with high yield (0.96 g/g) and productivity (2.25-3.23 g/l/h) was obtained by using non-detoxified wood hydrolysate. Rice straw hydrolysate without detoxification was also tested and yielded a productivity rate as high as 5.27 g/l/h. Therefore, L. paracasei 7 BL represents a potential method of l-lactic acid production from lignocellulosic biomass and has attractive application for industries.
journal_name
Bioresour Technoljournal_title
Bioresource technologyauthors
Kuo YC,Yuan SF,Wang CA,Huang YJ,Guo GL,Hwang WSdoi
10.1016/j.biortech.2015.09.071subject
Has Abstractpub_date
2015-12-01 00:00:00pages
651-7eissn
0960-8524issn
1873-2976pii
S0960-8524(15)01350-4journal_volume
198pub_type
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