当前位置： SCI文献检索 > Photodiagnosis and Photodynamic Therapy期刊下所有文献 > Photodynamic inactivation of methicillin-resistant Staphylococcus aureus on skin using a porphyrinic formulation.

Photodynamic inactivation of methicillin-resistant Staphylococcus aureus on skin using a porphyrinic formulation.

Abstract：

:Staphylococcus aureus is responsible for skin and soft tissue infections. Having in mind increased antibiotic resistance, in this study the efficacy of antimicrobial photodynamic therapy (aPDT) with a porphyrinic formulation (FORM) as photosensitizer (PS) to photoinactivate methicillin-resistant Staphylococcus aureus (MRSA) on skin was evaluated. Potassium iodide (KI) and iodopovidone (PVP-I) were also tested in combination with FORM as potentiator agents of FORM efficacy. The aPDT protocol was first developed in Phosphate Buffered Saline (PBS, in vitro). Porcine skin was artificially contaminated with MRSA (ex vivo) and treated with FORM, FORM + KI or FORM + PVP-I under white light. The in vitro results showed that FORM was effective to inactivate MRSA. A substantial reduction in the irradiation time, when compared to FORM alone, was observed for FORM + KI and FORM + PVP-I combinations. On skin, reductions in MRSA survival of 3.1 Log10 colony forming units (CFU) mL-1 were observed with FORM at 50 μM. Although the combined action of FORM + KI and FORM + PVP-I potentiated the aPDT efficacy in vitro, this was not observed ex vivo. Overall, the results showed that aPDT using FORM, even without coadjutants, is a promising approach for MRSA inactivation on skin.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Braz M,Salvador D,Gomes ATPC,Mesquita MQ,Faustino MAF,Neves MGPMS,Almeida A

doi

10.1016/j.pdpdt.2020.101754

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

101754

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(20)30107-1

journal_volume

30

pub_type

杂志文章

相关文献

Photodiagnosis and Photodynamic Therapy文献大全
  • Monitoring the effectiveness of photodynamic therapy with periodic renewal of the photosensitizer on intracanal Enterococcus faecalis biofilms.

    abstract：BACKGROUND AND OBJECTIVE:Photodynamic therapy (PDT) can eliminate microorganisms in a root canal. However, the parameters for disinfection remain undefined. This study assessed the effectiveness of a PDT protocol against intracanal Enterococcus faecalis biofilms. MATERIALS AND METHODS:Root canals were contaminated wit...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.01.002

    authors： Soares JA,Santos Soares SMC,Santos César CA,de Carvalho MAR,Brito-Júnior M,de Sousa GR,Soares BM,de Macêdo Farias L

    更新日期：2016-03-01 00:00:00

  • A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series.

    abstract：BACKGROUND:Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the study was to evaluate the efficacy of PDT in the treatment of ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.01.178

    authors： Sulewska M,Duraj E,Sobaniec S,Graczyk A,Milewski R,Wróblewska M,Pietruski J,Pietruska M

    更新日期：2017-06-01 00:00:00

  • Photodynamic therapy effect on cell growth inhibition induced by Radachlorin and toluidine blue O on Staphylococcus aureus and Escherichia coli: An in vitro study.

    abstract：INTRODUCTION:Photodynamic therapy is an innovative treatment modality, which is appropriate for tumor detection and for the treatment of cancer as well as nontumoral diseases, such as psoriasis (2), bacterial and viral eradication. MATERIAL AND METHOD:Effect of two photosensitizer (toluidine blue O (TBO) and Radachlor...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.07.001

    authors： Fekrazad R,Zare H,Vand SM

    更新日期：2016-09-01 00:00:00

  • Dissecting cellulitis of the scalp successfully treated with ALA-PDT: Case report.

    abstract：:A case of recalcitrant dissecting cellulitis of the scalp (DCS) in a 23-year-old male patient was treated with 4 times of topical ALA-PDT at intervals of 10-15 days. The patient responded well without any unbearable adverse effects and presented satisfactory effects. Before applying this therapy, the patient and his d...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.10.001

    authors： Zhan Y,Chen X,Zhou Y,Zou P,Xiao R

    更新日期：2018-12-01 00:00:00

  • Cure of condyloma acuminata covering the glans penis using aminolevulinic acid/photodynamic therapy.

    abstract：:Condyloma acuminata are a type of verrucous hyperplasia in the genital and perianal areas caused by human papilloma virus (HPV) infection. Traditional treatment methods for condyloma acuminata, such as topical medications, carbon dioxide (CO2) laser, cryotherapy, and surgical excision, can be effective at removing war...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type：

    doi：10.1016/j.pdpdt.2020.101658

    authors： Yin G,Zhang Y,Geng M,Cai B,Zheng Y

    更新日期：2020-06-01 00:00:00

  • In vitro photodynamic inactivation of Candida species and mouse fibroblasts with phenothiazinium photosensitisers and red light.

    abstract：:In the present study, the in vitro susceptibilities of five Candida spp. to photodynamic antimicrobial chemotherapy (PACT) with four phenothiazinium derivatives, methylene blue (MB), new methylene blue N (NMBN), toluidine blue O (TBO) and the novel pentacyclic phenothiazinium photosensitiser S137, in combination with ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.11.004

    authors： Rodrigues GB,Dias-Baruffi M,Holman N,Wainwright M,Braga GU

    更新日期：2013-05-01 00:00:00

  • Photodynamic therapy combined with surgery for hidradenitis suppurativa: A case report.

    abstract：:Hidradenitis Suppurativa (HS) is a distressing painful chronic inflammatory skin follicular condition. It is a challenge to achieve better therapeutic effect and lower recurrence rate. In this report, ALA-PDT combined with surgery for the treatment achieved ulcer healing, pain elimination, with no relapse during our f...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.07.024

    authors： Luo D,Tan Y,Cheng Q,Wu J,Lei X

    更新日期：2019-12-01 00:00:00

  • 5-aminolevulinic acid mediated photodynamic therapy inhibits survival activity and promotes apoptosis of A375 and A431 cells.

    abstract：OBJECTIVES:The purpose of this study was to investigate the effects of 5-aminolaevulinic acid mediated photodynamic therapy (ALA-PDT) on the survival activity and apoptosis of human melanoma cell line A375 and non-melanoma skin carcinoma cell line A431 cells. The mechanism for cellular apoptosis was explored. METHODS:...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.01.004

    authors： Cai J,Zheng Q,Huang H,Li B

    更新日期：2018-03-01 00:00:00

  • Comparison between the outcomes of fluorescein angiography-guided and indocyanine green angiography-guided half-time photodynamic therapy for central serous chorioretinopathy.

    abstract：BACKGROUND AND OBJECTIVES:This study aimed to compare the efficacy of fluorescein angiography (FA)-guided and indocyanine green angiography (ICGA)-guided half-time photodynamic therapy (PDT) for central serous chorioretinopathy (CSC). SUBJECTS AND METHODS:Medical records of 61 eyes of 61 CSC patients who underwent hal...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101955

    authors： Hayashida M,Miki A,Honda S,Nakamura M

    更新日期：2020-09-01 00:00:00

  • Antimicrobial photodynamic therapy and guided endodontics: A case report.

    abstract：:A 35-year-old woman with a history of pulp canal obliteration (PCO) and apical periodontitis was treated with guided endodontics combined with antimicrobial photodynamic therapy (aPDT). The use of aPDT was paramount to the approach performed, and its application should be encouraged in cases of severely calcified cana...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101935

    authors： Tavares WLF,Ferreira MVL,de Carvalho Machado V,Braga T,Amaral RR,Cohen S

    更新日期：2020-09-01 00:00:00

  • Autofluorescence spectroscopy for NADH and flavoproteins redox state monitoring in the isolated rat heart subjected to ischemia-reperfusion.

    abstract：BACKGROUND:Reduction of myocardial ischemia-reperfusion injury in the patients undergoing cardiac surgery under cardiopulmonary bypass represents an important goal. Intraoperative monitoring of myocardial metabolic state using continuous registration of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucl...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2014.05.003

    authors： Papayan G,Petrishchev N,Galagudza M

    更新日期：2014-09-01 00:00:00

  • Mitomycin C-induced cell cycle arrest enhances 5-aminolevulinic acid-based photodynamic therapy for bladder cancer.

    abstract：BACKGROUND:Photodynamic therapy (PDT) and diagnosis (PDD) using 5-aminolevulinic acid (ALA) to control the production of the intracellular photosensitizer protoporphyrin IX (PpIX) are commonly used clinically. Previously, we demonstrated that dormant and drug-induced dormancy-like cancer cells accumulated high PpIX lev...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101893

    authors： Nakayama T,Nozawa N,Kawada C,Yamamoto S,Ishii T,Ishizuka M,Namikawa T,Ogura SI,Hanazaki K,Inoue K,Karashima T

    更新日期：2020-09-01 00:00:00

  • An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin.

    abstract：BACKGROUND:Although discovered over a century ago it is only in the last 25 years that photodynamic therapy (PDT) has been the focus of intense research. This versatile treatment modality has been shown to be effective in treating a wide variety of malignancies, and with the increasing incidence of non-melanoma skin ca...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2010.12.004

    authors： Lesar A,Ferguson J,Moseley H

    更新日期：2011-06-01 00:00:00

  • Photodynamic effect of curcumin on Vibrio parahaemolyticus.

    abstract：:Vibrio parahaemolyticus (V. parahaemolyticus) is currently a major cause of bacterial diarrhoea associated with seafood consumption. The objective of this study was to determine the inactivation effect of curcumin-mediated photodynamic action on V. parahaemolyticus. First of all, V. parahaemolyticus suspended in PBS b...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.05.004

    authors： Wu J,Mou H,Xue C,Leung AW,Xu C,Tang QJ

    更新日期：2016-09-01 00:00:00

  • Surface treatment of RMGIC to composite resin using different photosensitizers and lasers: A bond assessment of closed Sandwich restoration.

    abstract：AIM:The aim of present study was to assess and compare different conditioning methods (laser, PDT and conventional) on shear bond strength (SBS) of resin modified glass ionomer cement (RMGIC) bonded to composite (sandwich technique). MATERIAL AND METHODS:Fifty specimens were prepared from RMGIC and were packed in a te...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101965

    authors： Ghubaryi AAA,Ingle N,Basser MA

    更新日期：2020-12-01 00:00:00

  • The effectiveness of photodynamic and antibiotic gel therapy as an adjunct to mechanical debridement in the treatment of peri-implantitis among diabetic patients.

    abstract：AIM:The current clinical trial aimed to assess the effectiveness of adjunctive photodynamic therapy (aPDT) and adjunctive antibiotic gel therapy (aAGT) to treat peri-implantitis among patients with type 2 diabetes mellitus (T2DM). METHODS:Selected T2DM participants with peri-implantitis were distributed into 3 groups:...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102077

    authors： Ahmed P,Bukhari IA,Albaijan R,Sheikh SA,Vohra F

    更新日期：2020-12-01 00:00:00

  • Influences of galactose ligand on the uptake of TADF liposomes by HepG2 cells.

    abstract：:Glucose is the main energy substance to drive the physiological events of the cell.. Malignant cells exhibit a much higher rate of glycolysis than healthy cells to relieve the increased needs of energy. The higher metabolic rate induces the over-expression of the Glucose Transporter (GLUT) to transport more glucose in...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102014

    authors： Wang C,Chen Z,Tang X,Liu X,Na W,Li W,Liu T

    更新日期：2020-12-01 00:00:00

  • Photophysical properties and in vitro photocytotoxicity of disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX (Dimegine).

    abstract：:Photophysical and in vitro photocytotoxicity studies were performed for the photosensitizer Dimegine, a disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX with very low systemic toxicity. The singlet oxygen and luminescence quantum yield were ΦΔ = 0,65 ± 0,06, and Φƒ=0,11 ± 0,01 respectively, and were indepe...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.11.006

    authors： Dadeko AV,Lilge L,Kaspler P,Murav'eva TD,Starodubtcev AM,Kiselev VM,Zarubaev VV,Ponomarev GV

    更新日期：2019-03-01 00:00:00

  • Treatment of peritoneal carcinomatosis with photodynamic therapy: Systematic review of current evidence.

    abstract：BACKGROUND:Peritoneal carcinomatosis results when tumour cells implant and grow within the peritoneal cavity. Treatment and prognosis vary based on the primary cancer. Although therapy with intention-to-cure is offered to selective patients using cytoreductive surgery with chemotherapy, the prognosis remains poor for m...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.pdpdt.2017.10.021

    authors： Almerie MQ,Gossedge G,Wright KE,Jayne DG

    更新日期：2017-12-01 00:00:00

  • Photodynamic action of palmatine hydrochloride on colon adenocarcinoma HT-29 cells.

    abstract：:Palmatine hydrochloride (PaH) is a natural active compound from a traditional Chinese medicine (TCM). The present study aims to evaluate the effect of PaH as a new photosensitizer on colon adenocarcinoma HT-29 cells upon light irradiation. Firstly, the absorption and fluorescence spectra of PaH were measured using a U...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.05.005

    authors： Wu J,Xiao Q,Zhang N,Xue C,Leung AW,Zhang H,Xu C,Tang QJ

    更新日期：2016-09-01 00:00:00

  • Targeted photodynamic-induced singlet oxygen production by peptide-conjugated biodegradable nanoparticles for treatment of skin melanoma.

    abstract：BACKGROUND:Photodynamic therapy (PDT) has been determined to be a promising treatment modality in the most resistant tumors such as malignant melanoma. However, the key cytotoxic agent of PDT, -singlet oxygen (1O2) - represents a high risk of photodynamic-associated side effects e.g. skin photosensitization. Recently, ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.05.017

    authors： Sebak AA,Gomaa IEO,ElMeshad AN,AbdelKader MH

    更新日期：2018-09-01 00:00:00

  • Adhesive bond integrity of dentin conditioned by photobiomodulation and bonded to bioactive restorative material.

    abstract：AIM:The aim of this in-vitro study is to investigate the shear bond strength (SBS) of Bioactive bulk fill restorative material (BARM) (Activa) by surface pre-treatment using Er,Cr:YSGG (ECL) on dentin in comparison to conventional dentin conditioning techniques. MATERIAL AND METHODS:Sixty extracted non-carious, non-fr...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.08.014

    authors： Alkhudhairy F,Vohra F,Naseem M,Ahmad ZH

    更新日期：2019-12-01 00:00:00

  • The clinical trial on the safety and effectiveness of the photodynamic diagnosis of non-muscle-invasive bladder cancer using fluorescent light-guided cystoscopy after oral administration of 5-aminolevulinic acid (5-ALA).

    abstract：OBJECTIVE:To examine the utility and safety of photodynamic diagnosis (PDD) after oral administration of 5-aminolevulinic acid (5-ALA) (ALA-PDD) of non-muscle-invasive bladder cancer (NMIBC) using fluorescent-light (FL)-cystoscopy. METHODS:The study was a single-arm, open-label, multi-center prospective study on ALA-P...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.pdpdt.2015.12.011

    authors： Inoue K,Matsuyama H,Fujimoto K,Hirao Y,Watanabe H,Ozono S,Oyama M,Ueno M,Sugimura Y,Shiina H,Mimata H,Azuma H,Nagase Y,Matsubara A,Ito YM,Shuin T

    更新日期：2016-03-01 00:00:00

  • Optical biopsy using spectral camera in BCC and oral leukoplakia.

    abstract：:Basal cell carcinoma is one of the most common neoplasmatic diseases of the skin. Oral leukoplakia is precancerous stage. Early diagnosis of both diseases gives very good treatment results. Fluorescence spectroscopy is a new modality of diagnostics using excitation of absorbed PPIX in tumor. Spectroscopy is an objecti...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2008.10.001

    authors： Sieron A,Gibinski P,Pustelny T,Kwiatek S,Opilski Z,Kawczyk-Krupka A,Woznica T,Maciak E,Kubica W,Urbanczyk M,Latos W

    更新日期：2008-12-01 00:00:00

  • Treatment of verrucous carcinoma in penis with topical aminolevulinic acid photodynamic therapy: An effective and safe treatment method.

    abstract：BACKGROUND:Verrucous carcinoma of the penis is a rare disease characterized by verrucous lesions. The traditional treatment methods for verrucous carcinoma result in loss of sexual function are not satisfactory. The purpose of this study was to evaluate the safety and effect of topical aminolevulinic acid photodynamic ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.08.015

    authors： He X,Zhang J,Tan L,Wang W,Song Y,Wang H,Zhang X,Kou H,Lu Y

    更新日期：2018-12-01 00:00:00

  • Hyperspectral imaging for diagnosis and detection of ex-vivo breast cancer.

    abstract：BACKGROUND AND PURPOSE:Breast cancer is one of the most widely recognized tumors. .Diagnosis made in the early stage of disease may imporve outcomes. The discovery of malignant growth utilizing noninvasive light intrusive methods in lieu of conventional excisional biopsy may assist in achieving this goal. MATERIALS AN...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101922

    authors： Aboughaleb IH,Aref MH,El-Sharkawy YH

    更新日期：2020-09-01 00:00:00

  • Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp.

    abstract：:Follicular mucinosis (FM) is a rare inflammatory disorder histologically characterized by mucin deposition in the follicular epithelium. There is no standard therapy for FM and several treatments have been described in the literature. We present the case of a 59 year-old female affected by a recalcitrant FM with diffu...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.07.003

    authors： Giuffrida R,Borgia F,Marafioti I,Riso G,Cannavò SP

    更新日期：2019-09-01 00:00:00

  • Lacrimal gland mantle lymphoma treated with photodynamic therapy: overview and report of a case.

    abstract：:We present the successful use of interstitial photodynamic therapy in the treatment of lacrimal gland mantle cell lymphoma associated with cervical and axillary lymphadenopathy in a 59-year-old female. ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2009.12.003

    authors： Hamdoon Z,Jerjes W,Upile T,Osher J,Hopper C

    更新日期：2010-06-01 00:00:00

  • Photodynamic therapy: An option in mycosis fungoides.

    abstract：BACKGROUND:Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University. METHODS:We retrospectively...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.09.004

    authors： Pileri A,Sgubbi P,Agostinelli C,Infusino SD,Vaccari S,Patrizi A

    更新日期：2017-12-01 00:00:00

  • Acanthopanacis Cortex extract: A novel photosensitizer for head and neck squamous cell carcinoma therapy.

    abstract：OBJECTIVES:The aim of this study was to develop a novel photosensitizer from traditional plant extracts and to investigate the photodynamic therapy (PDT) effect and mechanism of action of the novel photosensitizer on KB and Hep-2 cells. METHODS:Fluorescence emission, cell viability, and intracellular distribution of c...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.02.020

    authors： Shi S,Cho H,Sun Q,He Y,Ma G,Kim Y,Kim B,Kim O

    更新日期：2019-06-01 00:00:00