Bone Marrow Aspirate Concentrate in Animal Long Bone Healing: An Analysis of Basic Science Evidence.

Abstract:

OBJECTIVES:Long bone fractures that fail to heal or show a delay in healing can lead to increased morbidity. Bone marrow aspirate concentrate (BMAC) containing bone mesenchymal stem cells (BMSCs) has been suggested as an autologous biologic adjunct to aid long bone healing. The purpose of this study was to systematically review the basic science in vivo evidence for the use of BMAC with BMSCs in the treatment of segmental defects in animal long bones. DATA SOURCES:The PubMed/MEDLINE and EMBASE databases were screened in July 14-25, 2014. STUDY SELECTION:The following search criteria were used: [("bmac" OR "bone marrow aspirate concentrate" OR "bmc" OR "bone marrow concentrate" OR "mesenchymal stem cells") AND ("bone" OR "osteogenesis" OR "fracture healing" OR "nonunion" OR "delayed union")]. DATA EXTRACTION:Three authors extracted data and analyzed for trends. Quality of evidence score was given to each study. DATA SYNTHESIS:Results are presented as Hedge G standardized effect sizes with 95% confidence intervals. RESULTS:The search yielded 35 articles for inclusion. Of studies reporting statistics, 100% showed significant increase in bone formation in the BMAC group on radiograph. Ninety percent reported significant improvement in earlier bone healing on histologic/histomorphometric assessment. Eighty-one percent reported a significant increase in bone area on micro-computed tomography. Seventy-eight percent showed a higher torsional stiffness for the BMAC-treated defects. CONCLUSION:In the in vivo studies evaluated, BMAC confer beneficial effects on the healing of segmental defects in animal long bone models when compared with a control. Proof-of-concept has been established for BMAC in the treatment of animal segmental bone defects.

journal_name

J Orthop Trauma

authors

Gianakos A,Ni A,Zambrana L,Kennedy JG,Lane JM

doi

10.1097/BOT.0000000000000453

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

1-9

issue

1

eissn

0890-5339

issn

1531-2291

journal_volume

30

pub_type

杂志文章,评审
  • Rotator Cuff-Sparing Approach for Antegrade Humeral Nailing With Biceps Tenodesis: A Technical Trick With Clinical Implications.

    abstract::Antegrade intramedullary nails are an established, effective method of fixation for humeral shaft fractures. One significant limitation of this technique is chronic postoperative shoulder pain, which is likely related to the standard approach that involves splitting the rotator cuff to gain access to the nail starting...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000000684

    authors: Christ AB,Gausden EB,Warner SJ,Nellestein AM,Thacher RR,Lorich DG

    更新日期:2017-02-01 00:00:00

  • Complications of nailing in closed tibial fractures.

    abstract::Reamed intramedullary nailing was used to treat 102 closed tibial shaft fractures. Although a high rate of union was achieved (98%), we noted a higher incidence of complications than previously reported. Thirty-five (37%) patients exhibited one or more components of malunion. In 17 (18%) patients, further operative pr...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-199509060-00004

    authors: Williams J,Gibbons M,Trundle H,Murray D,Worlock P

    更新日期:1995-01-01 00:00:00

  • Transulnar percutaneous pinning of displaced distal radial fractures: a preliminary report.

    abstract::Difficulty in maintaining the reduction of displaced radial fractures has prompted the use of numerous techniques to address this problem. The purpose of this study was to determine if four or five 0.045-in Kirschner pins when placed percutaneously through the ulna into the radius could maintain the reduction of this ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-198906000-00004

    authors: Rayhack JM,Langworthy JN,Belsole RJ

    更新日期:1989-01-01 00:00:00

  • Intraoperative CT and Surgical Navigation for Iliosacral Screws: Technique for Patients With Sacral Dysmorphism.

    abstract::Percutaneous iliosacral screw (IS) fixation for pelvic ring injuries with the use of an O-arm imaging system has been associated with decreased procedure time and improved accuracy of IS screw placement compared with the use of fluoroscopic guidance. Specifically, patients with sacral dysmorphism require identificatio...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000001213

    authors: Khan JM,Lara DL,Marquez-Lara A,Rosas S,Hasty E,Pilson HT

    更新日期:2018-08-01 00:00:00

  • Cross-sectional geometry of the sacral ala for safe insertion of iliosacral lag screws: a computed tomography model.

    abstract:OBJECTIVE:To measure the dimensions of the narrowest portion of the sacral ala for safe insertion of iliosacral lag screws. DESIGN:Computed tomography (CT) model. SETTING:Level One trauma center. PATIENTS:Thirteen adult patients underwent pelvic CT imaging. MAIN OUTCOME MEASURE:Axial CT scans of intact pelves were ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-200001000-00007

    authors: Noojin FK,Malkani AL,Haikal L,Lundquist C,Voor MJ

    更新日期:2000-01-01 00:00:00

  • Outcomes of Presumed Aseptic Long-Bone Nonunions With Positive Intraoperative Cultures Through a Single-Stage Surgical Protocol.

    abstract:OBJECTIVE:To evaluate the outcomes of a single-stage surgical protocol to treat a presumed aseptic long-bone nonunion with positive intraoperative cultures obtained at the time of surgery. DESIGN:Retrospective comparative series. SETTING:Orthopaedic specialty hospital. PATIENTS AND METHODS:We retrospectively identif...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000001084

    authors: Arsoy D,Donders JCE,Kleeblad LJ,Miller AO,Henry MW,Wellman DS,Helfet DL

    更新日期:2018-02-01 00:00:00

  • Intramedullary nailing of tibial shaft fractures distal to total knee arthroplasty.

    abstract::Tibial shaft fractures distal to total knee arthroplasty are rare, but they are likely to become more common with the increasing number of arthroplasty procedures being performed. These fracture patterns have been treated in the past either with closed reduction and casting/bracing or with open reduction internal fixa...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000000096

    authors: Haller JM,Kubiak EN,Spiguel A,Gardner MJ,Horwitz DS

    更新日期:2014-12-01 00:00:00

  • Rotational imaging of complex acetabular fractures.

    abstract::Understanding complex acetabular fractures is difficult and may require three-dimensional reformatted computed tomographic (CT) images. This paper evaluates a technique, digital rotational imaging (DRI), that displays multiple oblique images of the pelvis and acetabulum. When viewed statically, DRI provides optimal il...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-199801000-00011

    authors: Patel NH,Hunter J,Weber TG,Routt ML Jr

    更新日期:1998-01-01 00:00:00

  • Anatomic study of the lateral femoral cutaneous nerve with respect to the ilioinguinal surgical dissection.

    abstract:OBJECTIVE:To report on the anatomic variations of the lateral femoral cutaneous nerve with respect to the ilioinguinal surgical dissection. DESIGN:Cadaveric anatomic study. PATIENTS/PARTICIPANTS:Sixty-eight ilioinguinal dissections performed in fifty cadavers. INTERVENTION:The lateral femoral cutaneous nerve was ide...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-199901000-00005

    authors: Hospodar PP,Ashman ES,Traub JA

    更新日期:1999-01-01 00:00:00

  • The combined olecranon osteotomy, lateral paratricipital sparing, deltoid insertion splitting approach for concomitant distal intra-articular and humeral shaft fractures.

    abstract::Fractures of the distal humerus involving the articular surface can be challenging. The complexity of these fracture patterns increases when the distal fracture is associated with a concomitant humeral shaft fracture with significant proximal extension. The combined exposure technique described here allows for consist...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/01.bot.0000245988.23684.79

    authors: Lewicky YM,Sheppard JE,Ruth JT

    更新日期:2007-02-01 00:00:00

  • Operating room efficiency: benefits of an orthopaedic traumatologist at a level II trauma center.

    abstract:OBJECTIVES:Fellowship-trained orthopaedic traumatologists are presumably taught skill sets leading to "best practice" outcomes and more efficient use of hospital resources. This should result in more favorable economic opportunities when compared with general orthopaedic surgeons (GOSs) providing similar clinical servi...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0b013e3182a59d6b

    authors: Althausen PL,Kauk JR,Shannon S,Lu M,O'Mara TJ,Bray TJ

    更新日期:2014-05-01 00:00:00

  • Do Safe Radiographic Sacral Screw Pathways Exist in a Pediatric Patient Population and Do They Change With Age?

    abstract:OBJECTIVES:Iliosacral screw pathways in the first (S1) and second (S2) sacral segments are commonly used for adult pelvic ring stabilization. We hypothesize that radiographically "safe" pathways exist in pediatric patients. SETTING:Academic level I Trauma Center. PATIENTS:All patients between ages 2 and 16 years with...

    journal_title:Journal of orthopaedic trauma

    pub_type: 临床试验,杂志文章

    doi:10.1097/BOT.0000000000000421

    authors: Burn M,Gary JL,Holzman M,Heydemann JA,Munz JW,Galpin M,Ambrose CG,Achor TS,Kumaravel M

    更新日期:2016-01-01 00:00:00

  • Loss of Follow-up in Orthopaedic Trauma: Who Is Getting Lost to Follow-up?

    abstract:OBJECTIVES:Noncompliance with postoperative follow-up visits remains a common problem in orthopaedic trauma. The aim of this study was to identify risk factors for loss of follow-up after orthopaedic trauma. DESIGN:Retrospective review. SETTING:Urban level 1 academic trauma center. PATIENTS:A total of 307 (226 men/8...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000000346

    authors: Zelle BA,Buttacavoli FA,Shroff JB,Stirton JB

    更新日期:2015-11-01 00:00:00

  • Severe open tibial fractures: a study protocol.

    abstract::A prospective randomized study of severe open tibial fractures (Type II and III) was performed. Individual fractures were randomized to treatment groups according to initial antibiotic therapy: One consisted of a first-generation cephalosporin, and the other consisted of a third-generation cephalosporin. Initial antib...

    journal_title:Journal of orthopaedic trauma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005131-198802030-00001

    authors: Johnson KD,Bone LB,Scheinberg R

    更新日期:1988-01-01 00:00:00

  • Induced Membrane Technique: Pearls and Pitfalls.

    abstract::The induced membrane technique for reconstruction of bone defects has proved its effectiveness and is now widely accepted. The 2 stages procedure, implying a cement spacer in the first stage and a huge bone graft in the second stage, responds to rigorous technical details involving each phase of the procedure. Prerequ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审

    doi:10.1097/BOT.0000000000000979

    authors: Masquelet AC

    更新日期:2017-10-01 00:00:00

  • Change over time of SF-36 functional outcomes for operatively treated unstable ankle fractures.

    abstract:OBJECTIVE:Ankle fractures are one of the most common operatively treated lower extremity fractures. Several studies indicate that patients often have residual effects after this injury. The purpose of this study is to use the SF-36 questionnaire at two times to assess patients' functional recovery and residual effects ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-200201000-00007

    authors: Obremskey WT,Dirschl DR,Crowther JD,Craig WL 3rd,Driver RE,LeCroy CM

    更新日期:2002-01-01 00:00:00

  • Histomorphometry of distraction osteogenesis during experimental tibial lengthening.

    abstract:OBJECTIVES:The aim of the current study was to analyze distraction osteogenesis histomorphometrically to investigate the amount of enchondral ossification adjacent to intramembranous ossification. STUDY DESIGN:Species-specific, longitudinal time study. METHODS Lengthening of 25% of the right tibia was performed in 24 ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-200302000-00006

    authors: Fink B,Pollnau C,Vogel M,Skripitz R,Enderle A

    更新日期:2003-02-01 00:00:00

  • Bone and cartilage formation in an experimental model of distraction osteogenesis.

    abstract:OBJECTIVES:(a) To develop a reliable and reproducible system for distraction osteogenesis in the rat to establish a model for future investigations of bone repair and regeneration. (b) To describe and characterize the histological events in distraction osteogenesis in the rat and to determine whether cartilage developm...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-199802000-00008

    authors: Jazrawi LM,Majeska RJ,Klein ML,Kagel E,Stromberg L,Einhorn TA

    更新日期:1998-02-01 00:00:00

  • Vertically Oriented Femoral Neck Fractures: A Biomechanical Comparison of 3 Fixation Constructs.

    abstract:OBJECTIVES:To compare the static and dynamic mechanical properties of a modified crossed cannulated screw (CS) configuration, the inverted triangle (IT) cannulated screw configuration, and a compression hip screw (CHS) with derotation screw in Pauwels type III femoral neck fractures. METHODS:Thirty synthetic femora we...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000000836

    authors: Johnson JP,Borenstein TR,Waryasz GR,Klinge SA,McClure PK,Chambers AB,Hayda RA,Born CT

    更新日期:2017-07-01 00:00:00

  • Efficacy of popliteal block in postoperative pain control after ankle fracture fixation: a prospective randomized study.

    abstract:OBJECTIVES:To compare postoperative pain control in patients treated surgically for ankle fractures who receive popliteal blocks with those who received general anesthesia alone. DESIGN:Institutional Review Board approved prospective randomized study. SETTING:Metropolitan tertiary-care referral center. PATIENTS:All ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/BOT.0b013e3182638b25

    authors: Goldstein RY,Montero N,Jain SK,Egol KA,Tejwani NC

    更新日期:2012-10-01 00:00:00

  • Intramedullary allograft fibula as a reduction and fixation tool for treatment of complex proximal humerus fractures with diaphyseal extension.

    abstract:SUMMARY:In this study, we present a novel technique for reduction and fixation of complex, unstable proximal humerus fractures with diaphyseal extension with the assistance of fibula allograft. We treated 14 patients using this technique since 2009 and found that it improves the reduction and enhances fixation while ma...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0b013e31829a346d

    authors: Berkes MB,Little MT,Lazaro LE,Cymerman RM,Pardee NC,Helfet DL,Dines JS,Lorich DG

    更新日期:2014-03-01 00:00:00

  • Connective tissue parameters in experimental nonunion.

    abstract::A previously developed experimental model for producing nonunions in rats was used to study the biochemical changes of connective tissue parameters in impaired fracture repair. The model is based on rotational instability between the fracture fragments. A mid-diaphyseal femoral osteotomy was performed on 30 male rats ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-199602000-00007

    authors: Hietaniemi K,Paavolainen P,Penttinen R

    更新日期:1996-01-01 00:00:00

  • Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update.

    abstract::Fracture healing is a unique multifaceted process requiring the presence of cells, molecular mediators, and angiogenic factors. The state of inflammation dominates the initial phase, but the ideal magnitude and duration of the process for an optimal outcome remains obscure. Biological response modifiers, such as plate...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审

    doi:10.1097/BOT.0000000000000465

    authors: Giannoudis PV,Hak D,Sanders D,Donohoe E,Tosounidis T,Bahney C

    更新日期:2015-12-01 00:00:00

  • Surgical treatment of a displaced lateral malleolus fracture: the antiglide technique versus lateral plate fixation.

    abstract:OBJECTIVES:To assess the outcomes of the surgical management of "isolated" displaced lateral malleolar fractures, comparing the techniques of lateral plating and antiglide plating as described previously. DESIGN:This is a retrospective review, being largely a surgeon-randomized comparative study. SETTING:The study wa...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-200208000-00008

    authors: Lamontagne J,Blachut PA,Broekhuyse HM,O'Brien PJ,Meek RN

    更新日期:2002-08-01 00:00:00

  • Inadvertent intraforaminal iliosacral screw placement despite apparent appropriate positioning on intraoperative fluoroscopy.

    abstract::We present the case of an intraforaminal iliosacral screw placed percutaneously with aid of C-arm using inlet, outlet, and lateral views of the pelvis. The iliosacral screw was placed above the S1 foramen on the outlet view, into the middle of S1 via the ala on the inlet view, and below the cortical shadow of the ala ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/00005131-200502000-00010

    authors: Sagi HC,Lindvall EM

    更新日期:2005-02-01 00:00:00

  • Building Networks for Global Clinical Research: The Basics.

    abstract::Over the last several decades, interest in global health across all fields of medicine, including orthopaedic surgery, has grown markedly. Cross-national collaborations are an effective means of conducting high-quality clinical research and offer many advantages over single-center investigations. Successful collaborat...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000000466

    authors: Shearer DW,Volberding PA,Schemitsch EH,Cook GE,Slobogean GP,Morshed S

    更新日期:2015-12-01 00:00:00

  • Donor Site Morbidity After Anterior Iliac Bone Graft Harvesting.

    abstract:OBJECTIVES:The objective of this study was to evaluate donor site morbidity associated with anterior iliac crest bone graft harvesting for orthopaedic trauma reconstructions. DESIGN:Retrospective case series. SETTING:Level 1 trauma center. PATIENTS:Forty-Six consecutive patients who had undergone anterior iliac cres...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000000551

    authors: Shin SR,Tornetta P 3rd

    更新日期:2016-06-01 00:00:00

  • Segmental Tibia Fractures: An Analysis of Complication and Healing Rates.

    abstract:OBJECTIVES:To determine the most commonly associated injuries, complications, and healing rates of patients sustaining segmental tibial shaft fractures. DESIGN:Retrospective review. SETTING:Two Level I trauma centers. PATIENTS:A total of 108 patients with segmental tibial shaft fractures were identified between 2005...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BOT.0000000000001132

    authors: Corey RM,Park NK,Cannada LK

    更新日期:2018-06-01 00:00:00

  • Foot Function After Surgically Treated Intraarticular Calcaneal Fractures: Correlation of Clinical and Pedobarographic Results of 65 Patients Followed for 8 Years.

    abstract:OBJECTIVES:To correlate functional deficits after surgical treatment of displaced intraarticular calcaneal fractures (DIACFs) as measured through dynamic pedobarography with clinical and radiographic long-term results. DESIGN:Retrospective single-center study. SETTING:Level 1 trauma center. PATIENTS:Sixty-five patie...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000001325

    authors: Dürr C,Apinun J,Mittlmeier T,Rammelt S

    更新日期:2018-12-01 00:00:00

  • Preoperative Testing for Hip Fracture Patients Delays Surgery, Prolongs Hospital Stays, and Rarely Dictates Care.

    abstract:OBJECTIVES:To determine how often preoperative testing is requested for geriatric hip fracture patients, to assess the extent to which preoperative testing is associated with delayed surgery, and to measure the frequency with which preoperative testing changes patient management. DESIGN:Retrospective. SETTING:Academi...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章

    doi:10.1097/BOT.0000000000000444

    authors: Bernstein J,Roberts FO,Wiesel BB,Ahn J

    更新日期:2016-02-01 00:00:00