Abstract:
BACKGROUND AND PURPOSE:With the discrepancy between availability and demand for corneal donors, the purpose of our study was to identify significant factors influencing the suitability and affecting the main reasons for discarding organ-cultured corneas. We thus aimed to minimise the percentage of unsuitable corneas in the long term. PATIENTS AND METHODS:4140 corneas of 2083 donors were analysed between 2006 and 2016. The factors included age, gender and medical history of the donors as well as storage factors such as post-mortem times. The data was recruited in a Microsoft Access database and evaluated with SPSS 20.0, using logistic regression analyses. In a multiple regression model, six factors influencing the suitability of the donor tissue were analysed. All corneas that did not meet the criteria for elective keratoplasty were considered unsuitable. RESULTS:A high donor age of > 80 years was found to be a significantly negative factor on the suitability of the cornea (p = 0.001) compared to the reference group of donors < 40 years. Previous cataract surgery (p < 0.001) also significantly reduced suitability. Male corneas were significantly less suitable than female corneas (p = 0.028). Hypertension (p = 0.612), chemotherapy (p = 0.745) or diabetes mellitus (p = 0.321) did not significantly affect the suitability. Sepsis (p = 0.026) and multiorgan failure (p < 0.001) as cause of death resulted in significantly higher discarding rates due to contamination of the culture medium. Corneas in which the blood sample collection took more than 12 h from death of the donor had to be discarded significantly more frequently due to a positive donor serology. CONCLUSIONS:Factors such as a history of cataract surgery and high donor age reduced the suitability of corneal donor tissue in organ culture. Diabetes, arterial hypertension and chemotherapy in the donor history did not statistically significantly affect the suitability of donor tissue. Causes of death such as sepsis or multi-organ failure increased the contamination rate of the medium. Post-mortem blood collection after more than 12 h should be avoided due to increased positive serology results. HINTERGRUND UND ZIEL DER STUDIE:Vor dem Hintergrund des Missverhältnisses zwischen Hornhautverfügbarkeit und -bedarf war das Ziel der Studie, signifikante Einflussfaktoren auf die Eignung sowie die Verwerfungsgründe von kornealem Spendergewebe zu eruieren und damit die Rate verworfener Hornhäute langfristig zu reduzieren. PATIENTEN UND METHODEN:4140 Hornhäute von 2083 Spendern wurden zwischen 2006 und 2016 analysiert. Die untersuchten Einflussgrößen umfassten das Alter, das Geschlecht und die medizinische Vorgeschichte der Spender und Prozessierungsfaktoren wie die Post-mortem-Zeit. Die Daten wurden in eine Microsoft-Access-Datenbank übertragen und mittels logistischer Regressionsanalysen mit SPSS 20.0 statistisch ausgewertet. In einem multiplen Regressionsmodell wurden 6 Einflussfaktoren auf die Eignung des Spendergewebes analysiert. Alle Hornhäute, die nicht für eine elektive Keratoplastik infrage kamen, galten hierbei als ungeeignet. ERGEBNISSE:Ein hohes Spenderalter > 80 Jahre erwies sich im Vergleich zur Referenzgruppe der Spender < 40 Jahre als signifikant negative Einflussgröße auf die Eignung der Hornhaut (p = 0,001). Auch eine vorangegangene Kataraktoperation minderte signifikant die Eignung (p < 0,001). Männliche Hornhäute waren signifikant weniger geeignet als weibliche Hornhäute (p = 0,028). Ein Hypertonus in der Spendervorgeschichte (p = 0,612), eine vorangegangene Chemotherapie (p = 0,745) oder ein Diabetes mellitus (p = 0,321) zeigten keinen Einfluss auf die Eignung. Sepsis (p = 0,026) und Multiorganversagen (MOV; p < 0,001) als Todesursachen des Spenders resultierten in signifikant höheren Verwerfungsraten aufgrund von Kontamination des Kulturmediums. Hornhäute, bei denen die Blutentnahme mehr als 12 h seit Versterben des Spenders zurücklag, mussten signifikant häufiger wegen einer positiven Spenderserologie verworfen werden (p < 0,001). SCHLUSSFOLGERUNGEN:Faktoren wie eine vorangegangene Kataraktoperation und ein hohes Spenderalter verringerten die Eignung des Spendergewebes. Ein Diabetes, ein Hypertonus und eine Chemotherapie in der Spendervorgeschichte zeigten keinen statistisch signifikanten Einfluss auf die Eignung. Todesursachen wie Sepsis und Multiorganversagen erhöhten die Kontaminationsrate des Kulturmediums. Eine postmortale Blutentnahme nach mehr als 12 h geht mit einem erhöhten Risiko für ein positives Serologieergebnis einher.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Kramp K,Suffo S,Laun D,Bischoff-Jung M,Huber M,Langenbucher A,Seitz Bdoi
10.1055/a-1141-3703subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1334-1342issue
11eissn
0023-2165issn
1439-3999journal_volume
237pub_type
杂志文章abstract::Six patients, members of a family with familial exudative vitreoretinopathy (FEVR), were studied to verify whether the disease was associated with a suspected platelet aggregation defect. No hemostaseologic defect was found in either the affected or healthy members of the family; in particular, there were no grounds f...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046328
更新日期:1989-01-01 00:00:00
abstract::We are indebted to François Guyot (4. 10. 1742-13. 6. 1816) for the term "loa," designating a species of filaria, pathogenic in humans, which is common tropical West Africa. Biographical details about this French ship's surgeon are published here for the first time. On several slave-trading voyages between Africa and ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 传,历史文章,杂志文章
doi:10.1055/s-2008-1050782
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:We describe a case of central serous chorioretinopathy associated with a large adrenal myelolipoma. HISTORY AND SIGNS:A 55-year old man was admitted to our clinic complaining for metamorphopsia and blurred vision in his left eye. Standard ophthalmologic examination and fluorescein angiography established th...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2003-38187
更新日期:2003-03-01 00:00:00
abstract::Visual acuity can be assessed by different strategies. The constant-stimulus-, the stair-case-, the Best-PEST-strategies, and the EN ISO 8596 are discussed. In cases of presumed psychogenic visual impairment and malingering it can be useful to modify these strategies striving for a determination of the (minimum) visua...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2004-812893
更新日期:2004-07-01 00:00:00
abstract::Lysosomal storage diseases represent a group of about 50 genetic disorders. The deficiencies of lysosomal and non-lysosomal proteins cause an accumulation of compounds which are normally degraded within the lysosome. There are currently no therapeutic options to cure patients suffering from a lysosomal storage disease...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0028-1109958
更新日期:2011-02-01 00:00:00
abstract::This review article focusses on the management of enhancements after corneal refractive laser surgery. Fundamental issues regarding enhancement embrace identification of the underlying reason for postoperative ametropia, assurance of stability of refraction, type of primary refractive laser treatment and thorough eval...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/a-1148-2744
更新日期:2020-07-01 00:00:00
abstract::A report is given on an advanced color video cartridge system and its application within various disciplines of ophthalmology. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-11-01 00:00:00
abstract::Canaliculitis is a rare disease of the lacrimal pathway, especially of the canaliculi. It is often not identified, therefore misdiagnosed and inadequately treated. It accounts 2 % of all lacrimal diseases. False diagnoses are usually conjunctivitis, blepharitis, dacryocystitis, hordeolum and chalazion. Besides viruses...
journal_title:Klinische Monatsblatter fur Augenheilkunde
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doi:10.1055/s-0029-1245424
更新日期:2010-07-01 00:00:00
abstract::This paper discusses the clinical application of a simplified irrigation-aspiration system for extracapsular cataract extraction. This simplified apparatus represents a reasonably-priced alternative to the existing expensive and complicated systems. When the surgeon has gained sufficient practice in the use of this me...
journal_title:Klinische Monatsblatter fur Augenheilkunde
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doi:
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications...
journal_title:Klinische Monatsblatter fur Augenheilkunde
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更新日期:2018-12-01 00:00:00
abstract:OBJECT:Results over a period of 24 months of performing the Er:YAG laser ab externo sclerostomy. MATERIAL AND METHODS:The procedure was performed 81 times (chronic glaucoma with open angle (n = 55) and narrow angle (n = 15), 6 secondary glaucoma, 4 pigment glaucoma, 1 normal pressure glaucoma) in 74 eyes of 64 patient...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035199
更新日期:1996-04-01 00:00:00
abstract::In 27 patients treated by silicone injection combined with pars plana vitrectomy various conditions of the retina were demonstrated by echography. As a result of silicone oil instillation the vitreous distance is prolonged and the sound absorption is higher. At the border of the silicone bubble the reflective echos ar...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:The treatment of high astigmatism after keratoplasty is often not possible with glasses or refractive corneal surgery, particularly in patients with anisometropia and contact lens incompatibility. METHODS:In 3 patients with cataract and high astigmatism after penetrating keratoplasty, phacoemulsification wa...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2004-813167
更新日期:2004-06-01 00:00:00
abstract::After some basic remarks about the physiological adhesions of the vitreous body to its surrounding structures in the anterior part of the eye (lens, ciliary body, pars plana) and the posterior part of the eye (macular, optic disc) the general history of bleeding in the vitreous body and the different possibilities of ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract:PURPOSE:To evaluate the effect of soft contact lenses with different lens power on the measured value of the intraocular pressure with non-contact pneumotonometry. METHODS:120 eyes (80 healthy volunteers: 50 women, 30 men, aged 22 to 61 years) were included in this study. Intraocular pressure was measured with a pneum...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2003-812564
更新日期:2003-12-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034963
更新日期:1998-09-01 00:00:00
abstract::Out of 1300 eyes enucleated between 1966-1974, 300 subsequently revealed histologically-proved malignant melanomas of the uvea. In 264 cases the clinical diagnosis was correctly made. In 36 cases the i.o. malignant melanomas were clinically unsuspected. The incorrect clinical diagnoses included: secondary glaucoma (30...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::The clinical data of 30 eyes with intraocular epithelial invasion were correlated to the histopathological findings (15 iridocyclectomies, four diagnostic iridectomies, one corneal button, ten globes). The diffuse (46.7%) and cystic (53.3%) types occurred with equal frequency. The correlation to the clinical data make...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050215
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054698
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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doi:10.1055/s-2008-1050221
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abstract:BACKGROUND:We investigated the presence of Nicotinamid-adenin-dinucleotid-phosphat (NADPH)-diaphorase activity in endothelial cells of the human uveal vessels, using a histochemical procedure which presumably localizes the reaction product nitric oxide. MATERIAL AND METHODS:11 donor eyes destined for corneal transplan...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035414
更新日期:1995-02-01 00:00:00
abstract::In 20 cases of herpes simplex keratitis the efficacy of Vidarabin ointment has been tested, in 19 cases after corneal abrasion. The eyes were treated once a day and padded until the epithelial defects had closed. Thereafter the ointment was applied 4 times per day for about one week more. On the average epithelial clo...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:
更新日期:1978-02-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
abstract::The survival rate was calculated using the life table method in 1,501 patients suffering from choroidal melanomas and treated in 10 eye hospitals in the GDR between 1960 and 1979. The results of treatment by (1) enucleation, (2) enucleation with postoperative irradiation of the orbit and (3) local irradiation with 106...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054399
更新日期:1984-01-01 00:00:00
abstract::A cases of Pyoderma vegetans attacking only the outer skin of the eyelid and leaving free the conjunctiva is reported. The diagnosis of this rare condition, belonging to the pemphigus diseases, depends on clinical course and especially on histological investigation. The aetiology of Pyoderma vegetans still remains unk...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00