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Egg yolk immunoglobulin Y as a promising tool to detect immune complexes in neurocysticercosis serum samples.

Abstract：

BACKGROUND:Neurocysticercosis (NCC) is a neglected tropical disease and its diagnosis is still a challenge due to non-specific manifestations. Neuroimaging techniques are used in the diagnosis of NCC, however, due to the high cost of these methods and the advantages presented in the use of immunological tests, such as ease of performance and satisfactory results, immunoassays are commonly used to detect antibodies against Taenia sp. antigens. The aim of the present study was to produce, characterize and apply specific polyclonal immunoglobulin Y (IgY) anti-Taenia crassiceps extracted from egg yolk of hens immunized with T. crassiceps metacestodes. METHODS:Indirect enzyme-linked immunosorbent assay (ELISA), avidity ELISA, immunoblotting and indirect immunofluorescence tests were performed for characterization of IgY antibodies. Diagnostic performance was verified by ELISA for immune complex detection testing 90 serum samples. RESULTS:Values of sensitivity, specificity, positive and negative likelihood ratios (LR+/LR-) and area under the curve (AUC) were calculated and presented the following results: sensitivity 83.3%, specificity 96.7%, AUC 0.966, LR+ 25.0 and LR- 0.17. CONCLUSIONS:Results of this pioneering and innovative study demonstrate that anti-T. crassiceps IgY antibodies present potential applicability and can be used as an efficient tool in human NCC serodiagnosis.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Silva GBD,Faria LSD,Lopes CA,Nunes DS,Ribeiro VS,de Sousa JEN,Paiva GCM,Gonçalves-Pires MRF,Borges IP,Santos MM,Ávila VMR,Júnior ÁF,Costa-Cruz JM

doi

10.1093/trstmh/traa028

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

585-592

issue

8

eissn

0035-9203

issn

1878-3503

pii

5850371

journal_volume

114

pub_type

杂志文章

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