Abstract:
:The most common bulk acoustic wave device used in biosensing applications is the quartz crystal microbalance (QCM), in which a resonant pure shear acoustic wave is excited via electrodes on both major faces of a thin AT-cut quartz plate. For biosensing, the QCM is used to detect the capture of a target by a target-capture film. The sensitivity of the QCM is typically based solely on the detection of mechanical property changes, as electrical property change detection is limited by the electrode on its sensing surface. A modification of the QCM called the lateral field excited (LFE) QCM (LFE-QCM) has been developed with a bare sensing surface as both electrodes are now on a single face of the quartz plate. Compared to the QCM, the LFE-QCM exhibits significantly higher sensitivity to both electrical and mechanical property changes. This paper presents theoretical and experimental aspects of LFE-QCMs. In particular, the presence and strength of the usual and newfound LFE-QCM modes depend on the electrical properties of the film and/or sensing environment. This work also presents examples of experimental setups for measuring the response of an LFE-QCM, followed by results of LFE-QCMs used to detect liquid electrical and mechanical properties, chemical targets, and biological targets. Finally, details are given about the attachment of various target-capture films to the LFE-QCM surface to capture biomarkers associated with diseases such as cancer.
journal_name
Biointerphasesjournal_title
Biointerphasesauthors
Hartz JSR,Emanetoglu NW,Howell C,Vetelino JFdoi
10.1116/6.0000144subject
Has Abstractpub_date
2020-06-02 00:00:00pages
030801issue
3eissn
1934-8630issn
1559-4106journal_volume
15pub_type
杂志文章相关文献
Biointerphases文献大全abstract::Biological membranes and their related molecular mechanisms are essential for all living organisms. Membranes host numerous proteins and are responsible for the exchange of molecules and ions, cell signaling, and cell compartmentation. Indeed, the plasma membrane delimits the intracellular compartment from the extrace...
journal_title:Biointerphases
pub_type: 杂志文章,评审
doi:10.1116/1.4994299
更新日期:2017-09-28 00:00:00
abstract::Simulations of water at hydrophilic self-assembled monolayer (SAM) surfaces are especially relevant for biological interfaces. Well-defined, atomically smooth surfaces that can be continuously varied are possible with SAMs. These characteristics enable more accurate measurements than many other surfaces with the added...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.2977751
更新日期:2008-09-01 00:00:00
abstract::Commonly used implants for therapeutic approaches of non-systemically impaired bone do not sufficiently support the healing process of osteoporotic bone. Since strontium (II) has been proven as an effective anti-osteoporotic drug new types of strontium enriched calcium phosphate bone cements were developed. As osteopo...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1186/1559-4106-8-17
更新日期:2013-12-01 00:00:00
abstract::In this study, the authors report that sodium citrate can aggregate hexadecyl-trimethyl-ammonium ion(+)-coated gold nanorods (AuNRs), and nucleic acids of different charge and structure properties, i.e., single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), single-stranded peptide nucleic acid (PNA), and PNA-DNA c...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.3496962
更新日期:2010-09-01 00:00:00
abstract::The stable nitroxide radical TEMPO [(2,2,6,6-Tetramethylpiperidin-1-yl)oxyl] has a multitude of applications in fields ranging from energy storage to biomedical applications and many more. However, to date, the processes of incorporating nitroxide radicals into thin-film coatings are laborious and not cost-effective, ...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/6.0000259
更新日期:2020-06-26 00:00:00
abstract::In plants, algae, and cyanobacteria, photosystem 2 (PS2) catalyzes the light driven oxidation of water. The main products of this reaction are protons and molecular oxygen. In vitro, however, it was demonstrated that reactive oxygen species like hydrogen peroxide are obtained as partially reduced side products. The tr...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4938090
更新日期:2015-03-22 00:00:00
abstract::Gold nanoparticles (AuNPs) functionalized with a short chain amine-terminated alkanethiol (HS-(CH(2))(2)NH(2) or C2 NH(2)-thiol) are prepared via a direct synthesis method and then ligand-exchanged with a long chain amine-terminated alkanethiol (HS-(CH(2))(11)NH(2) or C11 NH(2)-thiol). Transmission electron microscopy...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.3622481
更新日期:2011-09-01 00:00:00
abstract::Herein, the authors report and review polyelectrolyte complex (PEC) nanoparticles (NPs) loaded with zoledronate (ZOL) and simvastatin and their effects on bone cells. PEC NPs are intended for modification of bone substitute materials. For characterization, they can be solution casted on germanium (Ge) substrates servi...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4913195
更新日期:2015-03-23 00:00:00
abstract::Although protein-stabilized gold nanoclusters (AuNCs) have gathered recent attention as biocompatible peroxidase mimics, their practical utility has been critically limited by the low catalytic activity. Here, the authors have developed a nanohybrid material to significantly enhance the catalytic activity of AuNCs by ...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4974198
更新日期:2017-01-17 00:00:00
abstract::Shewanella oneidensis MR-1 is a dissimilatory metal-reducing bacterium capable of reducing various metal and sulfur compounds and precipitating them in nanoparticulate form. Here, we report the synthesis of molybdenum disulfide nanomaterials at the site of S. oneidensis biofilms grown in the presence of molybdenum tri...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/6.0000199
更新日期:2020-07-24 00:00:00
abstract::The limit of detection of advanced immunoassays, biochips and micro/nano biodetection devices is impacted by the non-specific adsorption of target molecules at the sample surface. In this paper, we present a simple and versatile low cost method for generating active surfaces composed of antibodies arrays surrounded by...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1186/1559-4106-8-37
更新日期:2013-12-01 00:00:00
abstract::Using infrared and Raman microspectroscopy, the authors examined the interaction of cold atmospheric plasma with the skin's built-in protective cushion, the outermost skin layer stratum corneum. Following a spectroscopic analysis, the authors could identify four prominent chemical alterations caused by plasma treatmen...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4919610
更新日期:2015-06-06 00:00:00
abstract::There has been much recent interest in the protein "corona," the nonspecific adsorption of proteins on the surface of nanoparticles used in biological applications. This research investigates an analogous DNA corona. We find that particles (200 nm and 1 μm) incubated with DNA form a DNA corona, with a higher concentra...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/6.0000439
更新日期:2020-10-01 00:00:00
abstract::A theoretical framework is developed to analyze molecular bond breaking in dynamic force spectroscopy using atomic force microscopy (AFM). An analytic expression of the observed bond breaking probability as a function of force is obtained in terms of the relevant physical parameters. Three different experimental reali...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.2188519
更新日期:2006-03-01 00:00:00
abstract::The precise use of nanoparticles in technological applications requires control over their surface properties. This implies the ability to quantitatively describe, for example, molecular coatings in terms of their thickness, areal mass, or number of molecules. Here, the authors describe two different approaches to the...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4913566
更新日期:2015-03-27 00:00:00
abstract::Two-dimensional molybdenum disulfide (MoS2) has attracted intense interest owing to its unique properties and promising biosensor applications. To develop effective biocompatible platforms, it is crucial to understand the interactions between MoS2 and biological molecules such as proteins, but little knowledge exists ...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4984803
更新日期:2017-06-02 00:00:00
abstract::Diamond has outstanding bulk properties such as super hardness, chemical inertness, biocompatibility, luminescence, to name just a few. In the nanoworld, in order to exploit these outstanding bulk properties, the surfaces of nanodiamond (ND) particles must be accordingly engineered for specific applications. Modificat...
journal_title:Biointerphases
pub_type: 杂志文章,评审
doi:10.1116/1.4927679
更新日期:2015-09-05 00:00:00
abstract::Coatings of biomaterials or implants that facilitate biomineralization possess a great potential for applications focused to the replacement, augmentation, and regeneration of bone tissue. Biomimetic approaches utilize biomolecules for either templating or supporting the crystallization process. One of these promising...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.3589176
更新日期:2011-06-01 00:00:00
abstract::Fluorescent nanodiamonds (NDs) coated with therapeutics and cell-targeting structures serve as effective tools for drug delivery. However, NDs circulating in blood can eventually interact with the blood-brain barrier, resulting in undesired pathology. Here, we aimed to detect interaction between NDs and adult brain ti...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/6.0000525
更新日期:2020-12-03 00:00:00
abstract::The authors investigate membrane composition-mediated interactions between proteins adsorbed onto a two-component lipid bilayer close to critical demixing using coarse-grained molecular dynamics simulations and a phenomenological Ginzburg-Landau theory. The simulations consist of three-bead lipids and platelike protei...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.2977492
更新日期:2008-06-01 00:00:00
abstract::Cationic amphiphilic peptides have been engineered to target both Gram-positive and Gram-negative bacteria while avoiding damage to other cell types. However, the exact mechanism of how these peptides target, bind, and disrupt bacterial cell membranes is not understood. One specific peptide that has been engineered to...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4982710
更新日期:2017-05-05 00:00:00
abstract::Not only bacteria but also fungal pathogens, particularly Candida species, can lead to biofilm infections on biomedical devices. By covalent grafting of the antifungal drug caspofungin, which targets the fungal cell wall, onto solid biomaterials, a surface layer can be created that might be able to provide long-term p...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4933108
更新日期:2015-12-14 00:00:00
abstract::Because dental implant abutments are located at transmucosal sites, their surface should inhibit bacterial accumulation to prevent peri-implantitis. The authors examined the effects of human lactoferrin (LF), an antibacterial protein present in saliva, as an antibacterial coating on the titanium surface and evaluated ...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4867415
更新日期:2014-06-01 00:00:00
abstract::It has been demonstrated that electric fields can minimize surface adhesion of bacteria, but how they affect the near-surface bacterial dynamics has remained largely overlooked. In the present study, the three-dimensional motions of Escherichia coli (E. coli) HCB1 and HCB1414 near a conductive surface under alternatin...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.5078543
更新日期:2019-02-20 00:00:00
abstract::The kinetics of adsorption and desorption of two highly asymmetrical model peptides were studied at methyl- and carboxylic acid-terminated alkylthiolate self-assembled monolayer (SAM) surfaces on gold. The model peptides were leucine-lysine (LK), α-helical (LKα14), and β-strand (LKβ15) peptides that have a well-define...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.3494080
更新日期:2010-12-01 00:00:00
abstract::Permanent implants made from titanium are widely used and successfully implemented in medicine to address problems related to orthopedic and oral disorders. However, implants that interact in all cases optimally and durably with bone tissue have yet to be developed. Here, the authors suggest a phospholipids 1-palmitoy...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4938556
更新日期:2015-03-29 00:00:00
abstract::Inhalation of combustion-derived ultrafine particles (≤0.1 μm) has been found to be associated with pulmonary and cardiovascular diseases. However, correlation of the physicochemical properties of carbon-based particles such as surface charge and agglomeration state with adverse health effects has not yet been establi...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.5043373
更新日期:2018-09-11 00:00:00
abstract::Titanium dental implants are commonly used for the replacement of lost teeth, but they present a considerable number of failures due to the infection on surrounding tissues. The aim of this paper is the development of a polyethylene glycol-like (PEG-like) coating on the titanium surface by plasma polymerization to obt...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.4913376
更新日期:2015-06-12 00:00:00
abstract::Inspired by the composition of the native extracellular matrix, biomimetic polyelectrolyte multilayers were assembled from polypeptides and the glycosaminoglycan chondroitin sulfate (CS). To investigate whether peptide conformation imposes an effect on the cell biological functions of osteoblasts, the secondary struct...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1007/s13758-012-0062-6
更新日期:2012-12-01 00:00:00
abstract::Force spectroscopy has been used to measure the adhesion of Saos-2 cells to a glass surface at different phases of the cell cycle. The cells were synchronized in three phases of the cell cycle: G(1), S, and G(2)M. Cells in these phases were compared with unsynchronized and native mitotic cells. Individual cells were a...
journal_title:Biointerphases
pub_type: 杂志文章
doi:10.1116/1.3139962
更新日期:2009-06-01 00:00:00