Abstract:
PURPOSE:To validate the usefulness of sennoside as a substitute for polyethylene glycol (PEG) as a mechanical bowel preparation (MBP) for elective colon cancer surgery. METHODS:We performed a prospective randomized non-inferiority trial comparing the use of sennoside and PEG in MBP for elective colon cancer surgery, in terms of the risk of surgical site infection (SSI) and the feasibility of surgery. RESULTS:The overall incidence of SSIs was 2.9 % in the sennoside group (n = 68) and 6.3 % in the PEG group (n = 63) with a difference of 3.4 % (95 % confidence interval 6.9-10.6 %). The intraoperative spillage of the stool materials in the sennoside and PEG groups was 4.4 and 3.1 %, respectively, and was not significantly different (p = 0.71), even the upstream stool consistency, was more frequently observed to be non-stool in the PEG group (65.1 vs. 30.9 %, p < 0.01). CONCLUSION:MBP with sennoside could be a substitution for PEG in elective colon cancer surgery.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Tajima Y,Ishida H,Yamamoto A,Chika N,Onozawa H,Matsuzawa T,Kumamoto K,Ishibashi K,Mochiki Edoi
10.1007/s00595-015-1239-7subject
Has Abstractpub_date
2016-06-01 00:00:00pages
735-40issue
6eissn
0941-1291issn
1436-2813pii
10.1007/s00595-015-1239-7journal_volume
46pub_type
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