Comparison of the risk of surgical site infection and feasibility of surgery between sennoside versus polyethylene glycol as a mechanical bowel preparation of elective colon cancer surgery: a randomized controlled trial.

Abstract:

PURPOSE:To validate the usefulness of sennoside as a substitute for polyethylene glycol (PEG) as a mechanical bowel preparation (MBP) for elective colon cancer surgery. METHODS:We performed a prospective randomized non-inferiority trial comparing the use of sennoside and PEG in MBP for elective colon cancer surgery, in terms of the risk of surgical site infection (SSI) and the feasibility of surgery. RESULTS:The overall incidence of SSIs was 2.9 % in the sennoside group (n = 68) and 6.3 % in the PEG group (n = 63) with a difference of 3.4 % (95 % confidence interval 6.9-10.6 %). The intraoperative spillage of the stool materials in the sennoside and PEG groups was 4.4 and 3.1 %, respectively, and was not significantly different (p = 0.71), even the upstream stool consistency, was more frequently observed to be non-stool in the PEG group (65.1 vs. 30.9 %, p < 0.01). CONCLUSION:MBP with sennoside could be a substitution for PEG in elective colon cancer surgery.

journal_name

Surg Today

journal_title

Surgery today

authors

Tajima Y,Ishida H,Yamamoto A,Chika N,Onozawa H,Matsuzawa T,Kumamoto K,Ishibashi K,Mochiki E

doi

10.1007/s00595-015-1239-7

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

735-40

issue

6

eissn

0941-1291

issn

1436-2813

pii

10.1007/s00595-015-1239-7

journal_volume

46

pub_type

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