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MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.

Abstract：

:Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism typified by stable proliferative arrest, a persistent DNA damage response, and the senescence-associated secretory phenotype (SASP), which helps to maintain the senescent state and triggers bystander senescence in a paracrine fashion. Here, we demonstrate that the tumor suppressive histone variant macroH2A1 is a critical component of the positive feedback loop that maintains SASP gene expression and triggers the induction of paracrine senescence. MacroH2A1 undergoes dramatic genome-wide relocalization during OIS, including its removal from SASP gene chromatin. The removal of macroH2A1 from SASP genes results from a negative feedback loop activated by SASP-mediated endoplasmic reticulum (ER) stress. ER stress leads to increased reactive oxygen species and persistent DNA damage response including activation of ATM, which mediates removal macroH2A1 from SASP genes. Together, our findings indicate that macroH2A1 is a critical control point for the regulation of SASP gene expression during senescence.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Chen H,Ruiz PD,McKimpson WM,Novikov L,Kitsis RN,Gamble MJ

doi

10.1016/j.molcel.2015.07.011

subject

Has Abstract

pub_date

2015-09-03 00:00:00

pages

719-31

issue

5

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(15)00569-9

journal_volume

59

pub_type

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