Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome and / or undergoing percutaneous coronary intervention.

Abstract:

:The use of triple antithrombotic therapy (TAT) consisting of an oral anticoagulant (OAC), aspirin, and a P2Y12 inhibitor in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) and / or undergoing percutaneous coronary intervention (PCI) is associated with a high risk of bleeding. Recently, several randomized clinical trials tested the hypothesis as to whether dual antithrombotic therapy (DAT) regimens (consisting of an OAC and a single antiplatelet drug) may be safer in terms of bleeding events as compared with TAT. They also investigated the role of non-vitamin K antagonist oral anticoagulants (NOACs) as a part of DAT and TAT. The purpose of this review is to provide an overview of available evidence regarding the safety and efficacy of DAT compared with TAT regimens, international guidelines recommendations, knowledge gaps, and unmet needs in the management of patients with AF and ACS and / or undergoing PCI.

journal_name

Kardiol Pol

journal_title

Kardiologia polska

authors

Mihajlovic M,Marinkovic M,Kozieł M,Mujovic N,Lip GYH,Potpara TS

doi

10.33963/KP.15428

subject

Has Abstract

pub_date

2020-06-25 00:00:00

pages

512-519

issue

6

eissn

0022-9032

issn

1897-4279

journal_volume

78

pub_type

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