Abstract:
:The use of triple antithrombotic therapy (TAT) consisting of an oral anticoagulant (OAC), aspirin, and a P2Y12 inhibitor in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) and / or undergoing percutaneous coronary intervention (PCI) is associated with a high risk of bleeding. Recently, several randomized clinical trials tested the hypothesis as to whether dual antithrombotic therapy (DAT) regimens (consisting of an OAC and a single antiplatelet drug) may be safer in terms of bleeding events as compared with TAT. They also investigated the role of non-vitamin K antagonist oral anticoagulants (NOACs) as a part of DAT and TAT. The purpose of this review is to provide an overview of available evidence regarding the safety and efficacy of DAT compared with TAT regimens, international guidelines recommendations, knowledge gaps, and unmet needs in the management of patients with AF and ACS and / or undergoing PCI.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Mihajlovic M,Marinkovic M,Kozieł M,Mujovic N,Lip GYH,Potpara TSdoi
10.33963/KP.15428subject
Has Abstractpub_date
2020-06-25 00:00:00pages
512-519issue
6eissn
0022-9032issn
1897-4279journal_volume
78pub_type
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journal_title:Kardiologia polska
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journal_title:Kardiologia polska
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journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
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journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
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pub_type: 传,历史文章,杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Kardiologia polska
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更新日期:2004-09-01 00:00:00
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journal_title:Kardiologia polska
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更新日期:2012-01-01 00:00:00
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