Abstract:
:A novel two-step in situ method for targeted antitumor drug release by supramolecular assembly (Fc-CPT@HACD) was constructed using camptothecin prodrug (Fc-CPT) and β-cyclodextrin (β-CD)-modified hyaluronic acid (HACD). Benefiting from the overexpressed H2O2 and glutathione (GSH) in tumor cells, Fc-CPT@HACD can be disassembled by oxidation of ferrocene (Fc) to Fc+, leading to an efficient release of the anticancer drug camptothecin (CPT) to induce tumor cell apoptosis without affecting normal cells. The in vivo experiment results also demonstrated that Fc-CPT@HACD possessed higher anticancer efficiency than free CPT, accompanied by negligible side effects.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Fu HG,Chen Y,Yu Q,Liu Ydoi
10.1021/acsmedchemlett.0c00040subject
Has Abstractpub_date
2020-05-18 00:00:00pages
1191-1195issue
6issn
1948-5875journal_volume
11pub_type
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