Abstract：
:An examination of eighteen thiols and thio ethers revealed that the simultaneous administration of several of these with cis-platinum (CDDP) at 7.5 mg/kg (25 mumols/kg) iv, as a single injection to rats bearing the Walker 256 carcinosarcoma led to significant reduction in the nephrotoxicity typically found with cis-platinum, and no apparent interference in its anti-neoplastic action towards this tumor. The thiols and thiol ethers were administered at a twenty-fold molar excess to the CDDP and were combined with the CDDP immediately prior to administration. The most effective compounds in suppression nephrotoxicity were D-, and L-methionine, methyl and ethyl L-methioninate, and N-acetyl-D, L-methionine.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Jones MM,Basinger MAsubject
Has Abstractpub_date
1989-11-01 00:00:00pages
1937-41issue
6eissn
0250-7005issn
1791-7530journal_volume
9pub_type
杂志文章abstract：BACKGROUND:The aim of this study was to investigate the diagnostic value of FDG PET in the follow-up for breast cancer in disease-free patients and patients suspected of having recurrent or metastatic disease. As a single imaging tool, PET can be compared with the conventional diagnostic means used for different examin...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil (5-FU). TS has a polymorphic repeated sequence in the 5'-UTR and the polymorphism is associated with TS protein expression. TS polymorphism has been reported to link with the efficacy of 5-FU-based chemotherapy in colorectal cancer. In this study, we exami...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：AIM:Neoadjuvant epirubicin/docetaxel (ET) combination chemotherapy was administered to breast cancer patients in order to investigate their clinical and pathological response. Moreover, the breast-conserving surgery (BCS) rate, disease-free (DFS) and overall survival (OS), safety profile and the correlation of biologic...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND/AIM:The lipophilic, orally bioavailable camptothecin analogue gimatecan is characterized by improved efficacy over conventional camptothecins on human tumor xenografts. Gimatecan produced excellent outcomes orally with prolonged, low-dose, daily treatments. The aim of this study was to assess the antitumor e...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12917
更新日期：2018-10-01 00:00:00
abstract：:Iron salts supplemented in a basal ratio, were fed to young Sprague-Dawley male rats for prolonged periods and the frequency of colonic adenocarcinomas induced by repeated s.c. injection of 1,2-dimethylhydrazine (DMH) at unit base doses of 9.0 mg/kg, ascertained and compared with the respective controls. In a series e...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:The present study was undertaken to evaluate the effect of phagocytosis of killed yeast on the induction of apoptosis in human metastatic breast cancer cells (MCF-7 and ZR-75-1) and non-metastatic breast cancer cells (HCC70). Heat-killed Saccharomyces cerevisiae, baker's and brewer's yeast, was cultured with cancer ce...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors resistant to platinum compounds has not yet been defined. This multicenter prospective phase II study evaluated the activity and toxicity of the docetaxel-plus-irinotecan combination in ovarian cancer patients whose ...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2005-09-01 00:00:00
abstract：:Nineteen patients with locally advanced inoperable carcinoma of the uterine cervix (8 with stage IIb, 8 with stage IIIb and 3 with stage IV) were treated with a cisplatin (100 mg/m2), aclacinomycin (30 mg/m2) and bleomycin (20 mg/m2) combination using balloon occluded arterial infusion (BOAI), and 5 patients (2 stage ...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND/AIM:Numerous trials have described a wide variation of metabolic complications associated with the mammalian target of rapamycin inhibitors (mTORi). This analysis aimed to report and critically analyze the risks of mTORi-associated metabolic complications. MATERIALS AND METHODS:A comprehensive search of all...
journal_title：Anticancer research
pub_type： 杂志文章,meta分析
doi：
更新日期：2016-04-01 00:00:00
abstract：:A human ovarian mesodermal mixed heterologous carcinoma, with a high content of cellular retinol-binding protein (CRBP), was used to study the effects of retinoid and hormonal treatment on tumour CRBP content, tumour growth rate, differentiation and turnover of CRBP. Tumour growth in general was accompanied by an incr...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The relationship between serum and cytosolic levels of carcinoembryonic (CEA), squamous-cell carcinoma (SCC) and CA125 antigens was determined in 122 patients with non-small cell lung cancer. A pronounced serum-cytosol gradient and a high degree of dispersion in the distribution of serum and cytosol marker concentrati...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:25 consecutive leukemia patients (21 AML, 4 ALL) with either primary resistance (n = 22) or resistant relapse (n = 3) of all FAB-subtypes were treated with 1 or 2 cycles of ID-ara C (1 g/m2 i.v. q 12h days 1-6) and AMSA (120 mg/m2 i.v. days 5-7). Patients reaching CR received 1 cycle of intensive consolidation using a...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：AIM:The current study reports the type of salvage chemotherapy following osimertinib and its treatment efficacy in patients with non-small-cell lung carcinoma (NSCLC) who acquire resistance to osimertinib. PATIENTS AND METHODS:In this retrospective cohort study, data from the medical charts of 40 patients with NSCLC t...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14186
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Extracts from Viscum album L. are widely used as an adjuvant in complementary cancer therapy. While the mechanisms of mistletoe lectin (ML) cytotoxicity are well described, the viscotoxin (VT) effects are unclear at present. Thus, we treated human lymphocytes with VT and measured cell death-associated change...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:Salen-manganese complexes, such as EUK-8 and EUK-134 are known as catalase mimetics with superoxide dismutase (SOD) and peroxidase mimetic activity. Here we show that the concentration-dependent use of salen-manganese complexes within the appropriate time window and with parallel control of signaling parameters allows...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Natural killer (NK) cells are a third population of lymphocytes that can kill certain tumor cells. This killing is regulated by signals received through activating and inhibitory receptors. 2B4 (CD244), a member of the CD2 subset of Immunoglobulin superfamily, was identified as an activating receptor on NK c...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Concurrent chemoradiotherapy with gemcitabine improves median survival for patients with unresectable pancreatic cancer. Recently, hyperfractionated accelerated radiotherapy (HART) has been used to treat these patients; however, the safety and efficacy are not well defined. PATIENTS AND METHODS:The standard...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：AIM:To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. PATIENTS AND METHODS:A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: pati...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：:In 1992 The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas was established to study the pathogenesis and natural history of the tumor and to support the most rational treatment. We collected 218 patients through a literature review and personal communications. We corresponded with several Authors t...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND/AIM:Up-regulation of metallo-proteinase (MMP) proteins has been shown in various types of solid cancers and the genotype of MMP1 has been associated with the risk of solid cancers. The contribution of MMP1 genotype to lung cancer has been investigated in various countries, though, to our knowledge, not in Ta...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12215
更新日期：2018-01-01 00:00:00
abstract：:We have previously shown that transfection of NIH 3T3 cells with the T24 H-ras oncogene converts the cells to a tumorigenic and metastatic phenotype, in proportion to levels of ras expression. We hypothesize that ras-induced increases in malignancy occur via altered expression of various genes. We have identified OPN ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The combined effects of Human papillomavirus (HPV) and Herpes simplex type 1 (HSV-1) infections and their effects on cancer cell radioresistance are unexplored. MATERIALS AND METHODS:An HPV16-positive hypopharyngeal carcinoma cell line (UD-SCC-2) was infected with wt-HSV-1 at low multiplicity of infection (...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：:Colchicine is an alkaloid widely used for the treatment of inflammatory diseases, such as gout. It suppresses cell division by inhibiting mitosis. We investigated the anticancer effects of colchicine on human hypopharyngeal cancer cells and the mechanisms underlying its anticancer effects. XTT cell proliferation assay...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12078
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Pharmacologically active components of ginseng, particularly protopanaxadiol (PPD)-type ginsenosides, have potent anticancer effects, although their effects on highly malignant glioblastoma multiforme (GBM) have not been systemically evaluated. Identification of effective anticancer ginsenosides and further ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND/AIM:To assess prognosis of women aged 75 and older according to breast cancer (BC) diagnosis circumstances. PATIENTS AND METHODS:A retrospective cohort study was conducted in the Amiens, France, regional oncologic referral center between 2005 and 2015. Two groups were formed depending on whether the patient...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11397
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Various localized side effects which accompany head and neck irradiation [IR] have been widely reported. However, systemic side effects/have been only sparsely reported in the short-term period post-IR in an animal model. The potential modulatory role of zinc-desferrioxamine [Zn-DFO] on IR effects was examin...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:Allelic loss at specific chromosomal loci was demonstrated in carcinoma of the cervix (CaCx) obtained from Hong Kong Chinese by restriction fragment length polymorphism analysis. Altogether 12 patients with CaCx, 7 with cervical intraepithelial neoplasia (CIN) and 7 with normal cervical tissues were studied. Polymorph...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND/AIM:We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) alone for Stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS:Data of 65 patients (median age=73 years) with Stage III NSCLC who underwent CIRT alone in the QST Hospital, Chiba, Japan, between 1997 and 2015 were retros...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13963
更新日期：2020-01-01 00:00:00
abstract：:A circadian rhythm of serum concentrations of two tumor markers (CEA and AFP) was demonstrated in individuals not suffering from cancer. These rhythms exhibited a diurnal peak with a nocturnal dip. They disappeared in cancer groups. However, in some cancer subjects, a circadian activity was still detectable, but with ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
