Abstract:
:Cronobacter sakazakii is an opportunistic Gram-negative pathogen that could cause meningitis and necrotizing enterocolitis. Several Gram-negative bacteria use the PmrA/PmrB system to sense and adapt to environmental change by resistance to cationic antimicrobial peptides of host immune systems. The PmrA/PmrB two-component system regulates several genes to modify LPS structure in the bacterial outer membrane. The role of PmrA/PmrB of C. sakazakii has been studied within the current study. The results suggest that PmrA/PmrB plays a crucial role in modifying LPS structure, cationic antimicrobial peptide susceptibility, cell membrane permeability and hydrophobicity, and invading macrophage.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Hua J,Jia X,Zhang L,Li Ydoi
10.3389/fmicb.2020.00903subject
Has Abstractpub_date
2020-06-17 00:00:00pages
903issn
1664-302Xjournal_volume
11pub_type
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