Interleukin-1 production by human monocytes in ageing and disease.

Abstract:

:Interleukin-1 mediates the febrile response which is often said to be reduced in the elderly. Interleukin-1 production by monocytes cultured in vitro and stimulated with bacterial lipopolysaccharide was measured. Three groups of subjects were studied; 40 normal young, 33 well elderly and 40 elderly with a history of repeated infection. No difference in interleukin-1 secretion was found between the groups. When the group with recurrent infection was subdivided into those with a history of fever and those with no record of fever accompanying their infection, the group without fever produced significantly less interleukin-1 (p = 0.035).

journal_name

Age Ageing

journal_title

Age and ageing

authors

Rudd AG,Banerjee DK

doi

10.1093/ageing/18.1.43

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

43-6

issue

1

eissn

0002-0729

issn

1468-2834

journal_volume

18

pub_type

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