Abstract:
:The gastrointestinal nematode Heligmosomoides polygyrus bakeri shows enhanced survival in mice with colitis. As the antibody response plays an important role in antiparasitic immunity, antibodies against male and female L4 H. polygyrus were examined in mice with and without colitis. Levels of specific antibodies in the mucosa and serum were determined by enzyme-linked immunosorbent assay and immunogenic proteins of male and female parasites were identified using 2D electrophoresis and mass spectrometry. The function of identified proteins was explored with Blast2Go. Nematodes in mice with colitis induced higher levels of specific immunoglobulin G (IgG1) and IgA, a lower level of IgE in the small intestine and a higher level of IgE in serum against female L4. Infected mice with colitis recognized 12 proteins in male L4 and 10 in female L4. Most of the recognized proteins from male L4 were intermediate filament proteins, whereas the proteins from female L4 were primarily actins and galectins. Nematodes from mice with colitis were immunogenically different from nematodes from control mice. This phenomenon gives new insights into helminth therapy as well as host-parasite interactions.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Maruszewska-Cheruiyot M,Donskow-Łysoniewska K,Krawczak K,Szewczak L,Joachimiak E,Doligalska Mdoi
10.1017/S0031182020001201subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1480-1487issue
13eissn
0031-1820issn
1469-8161pii
S0031182020001201journal_volume
147pub_type
杂志文章相关文献
PARASITOLOGY文献大全abstract::Cryptosporidia are important protozoan parasites of vertebrates, and a number of species and genotypes, with different host ranges, have been described. In this study a protocol was established for the detection and the genetic characterization of Cryptosporidium spp. isolated from various types of surface waters (riv...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001001317
更新日期:2002-04-01 00:00:00
abstract::During the course of Schistosoma mansoni murine infection there is a dramatic increase of some immunoglobulins and S. mansoni-specific antibodies. The most substantial response is initiated after 40 days of infection and results in a prolonged increase of total IgG1, IgM and IgA. The maximum increase is respectively 2...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s003118200000072x
更新日期:1980-04-01 00:00:00
abstract::The genomes of more than 20 helminths have now been sequenced. Here we perform a meta-analysis of all sequenced genomes of nematodes and Platyhelminthes, and attempt to address the question of what are the defining characteristics of helminth genomes. We find that parasitic worms lack systems for surface antigenic var...
journal_title:Parasitology
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0031182014001449
更新日期:2015-02-01 00:00:00
abstract::Exponential decay in community similarity as a function of distance is a ubiquitous phenomenon in biogeography. Thus, for parasite communities, pairwise similarity decreases with increasing geographical distance between host populations. This biogeographical rule should also apply along other dimensions characterizing...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009991491
更新日期:2010-04-01 00:00:00
abstract::The mechanism by which Giardia lamblia exerts its pathogenicity is likely to be multifactorial. A 58 kDa enterotoxin was purified and characterized from the excretory-secretory product (ESP) of the parasite (Kaur et al. 2001). In the present study an attempt has been made to elucidate the mechanism of action of the ES...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004005852
更新日期:2004-10-01 00:00:00
abstract::Expansion of human activities frequently results in habitat fragmentation, a phenomenon that has been widely recognized in the last decades as one of the major threats to world's biodiversity. The transformation of a continuous forest into a fragmented area results in a hyper-dynamic landscape with unpredictable conse...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S003118200700323X
更新日期:2007-11-01 00:00:00
abstract::Cyst fluid (CF) of Taenia solium metacestode (TsM) is an important source of serodiagnostic antigens. We have investigated the molecular characteristics of the 120 kDa protein complex in TsM CF purified by fast performance liquid chromatography. The structure of the purified protein was characterized by a variety of p...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182005008504
更新日期:2005-12-01 00:00:00
abstract::Currently available methods for the diagnosis of human schistosomiasis often lack enough sensitivity and specificity. Recently, several authors have developed more specific and sensitive diagnostic methods, mainly based on the polymerase chain reaction (PCR) technique. Nevertheless, these have been only applied for th...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182006000898
更新日期:2006-11-01 00:00:00
abstract::The behaviour and development of Elasmosoma sp., near pergandei Ashm. (Neoneurinae: Braconidae: Hymenoptera), a parasite of the ant, Formica obscuriventris clivia Creighton, was studied in a coastal sand dune habitat in central Oregon over a 2-year period. Female wasps oviposited into the abdomen of major worker ants ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004004809
更新日期:2004-05-01 00:00:00
abstract::The worldwide economic impact of Neospora caninum infection has caused the development of effective vaccines to become one of the main goals in the field of neosporosis research. In this study, the protection conferred by antigens from inactivated whole tachyzoites (TZ) and a tachyzoite-bradyzoite mixture (TZ-BZ) of N...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182011001156
更新日期:2011-09-01 00:00:00
abstract::SUMMARY Leishmania are protozoan parasites spread by a sandfly insect vector and causing a spectrum of diseases collectively known as leishmaniasis. The disease is a significant health problem in many parts of the world, resulting in an estimated 1·3 million new cases and 30 000 deaths annually. Current treatment is b...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S003118201400095X
更新日期:2014-07-30 00:00:00
abstract::Host nutrition plays an important role in determining the development and success of parasitic infections. While studies of vertebrate hosts are accumulating, little is known about how host nutrition affects parasites of invertebrate hosts. Crithidia bombi is a gut trypanosome parasite of the bumble bee, Bombus terres...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182005007304
更新日期:2005-06-01 00:00:00
abstract::Monoclonal antibodies reacting with pellicular antigens of Toxoplasma gondii tachyzoites have been selected among hybridomas produced against this organism by immunofluorescence assay. These antigens have been further characterized by immunofluorescence on living zoites, Western immunoblotting and immunoprecipitation ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000066695
更新日期:1988-08-01 00:00:00
abstract::Murine monoclonal antibodies (mAbs) against Neospora caninum tachyzoites were produced to identify the cross-reactive antigens between N. caninum and Toxoplasma gondii. Ten mAbs recognizing cross-reactive antigens of both parasites were obtained and tentatively classified into 6 different groups based on their reactiv...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004006948
更新日期:2005-05-01 00:00:00
abstract::The development of resistance in mice to reinfection with Schistosoma mansoni was recorded during an early chronic infection, and compared with hepatic portal pathological and vascular changes. The latter were assessed using a microsphere injection technique. The degree of acquired resistance was directly dependent on...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000053476
更新日期:1987-02-01 00:00:00
abstract::The present study was undertaken to investigate the antiparasitic activity of extracellular products of Streptomyces albus. Bioactivity-guided isolation of chloroform extracts affording a compound showing potent activity. The structure of the compound was elucidated as salinomycin (SAL) by EI-MS, 1H NMR and 13C NMR. I...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182018001919
更新日期:2019-04-01 00:00:00
abstract::The presence of superoxide dismutase (SOD) activity in the bovine lungworm Dictyocaulus viviparus was examined using the xanthine-xanthine oxidase assay system and by non-denaturing PAGE followed by specific enzyme staining. High levels of activity were detected in excretory-secretory (ES) products of adult worms and ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000076381
更新日期:1994-08-01 00:00:00
abstract::Pelodera strongyloides larvae were found in the conjunctival sacs of Apodemus sylvaticus and Clethrionomys glareolus and in hair follicles of A. sylvaticus. Those in the eyes were 3rd-stage larvae while most of those in the dermis were early 4th stages. There was no evidence of pathology and sections of the skin showe...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000050046
更新日期:1981-08-01 00:00:00
abstract::Factors which may be important in the large-scale extraction of coccidial oocysts from faeces ha.ve been investigated with Eimeria tenella. Age of bird, inoculum, feeding status at the time of inoculation, period of collection, feeding status during collection, collection medium, homogenization and sieving, flotation,...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000046990
更新日期:1976-12-01 00:00:00
abstract::Responses to Taenia taeniaeformis infection were studied in mice with severe combined immunodeficiency (scid), which lack functional T and B lymphocytes. In the early phase of infection, accumulation of polymorphonuclear leucocytes (PML) occurred around the larvae in the liver of scid mice and their immunocompetent co...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000061825
更新日期:1992-04-01 00:00:00
abstract::The occurrence of multiple-clone Plasmodium falciparum haploid blood-stage infections is a pre-requisite for cross-fertilization and genetic exchange at the diploid stage in the mosquito. Using monoclonal antibodies against 3 polymorphic blood-stage antigens, a method of two-colour differential immunofluorescence allo...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000059217
更新日期:1991-08-01 00:00:00
abstract::Th2-biased inflammation with eosinophilia and IgE production is a hallmark of helminth infections. It is pronounced in hyperreactive onchocerciasis patients ('sowda' or 'local form'), who efficiently kill microfilariae resulting in severe dermatitis and lymphadenitis. In contrast, hyporeactive patients ('generalised f...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182010000922
更新日期:2011-01-01 00:00:00
abstract::A deterministic mathematical model which predicts the probability of developing a new drug-resistant parasite population within the human host is reported. The model incorporates the host's specific antibody response to PfEMP1, and also investigates the influence of chemotherapy on the probability of developing a viab...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001008824
更新日期:2001-12-01 00:00:00
abstract::Alveolar echinococcosis (AE) is a zoonotic parasitic diseases caused by a cestode parasite known as Echinococcus multilocularis. The parasite has a wildlife cycle with definitive hosts (foxes) and small mammals as intermediate hosts (rodents) while humans are the accidental hosts. Parasite infection pressure relation ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182019001720
更新日期:2020-03-01 00:00:00
abstract::The parasitic roundworms Strongyloides stercoralis (in man) and Strongyloides ratti (in rats) employ environmentally controlled XX/XO sex determination with a pair of X chromosomes and two pairs of autosomes. Strongyloides papillosus (in sheep) has only two pairs of chromosomes, one of which combines the genetic mater...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182013001315
更新日期:2013-12-01 00:00:00
abstract::Urinary schistosomiasis is an important source of human morbidity in Msambweni, Kenya, where the intermediate host snail, Bulinus nasutus is found in ponds and water pools. In the past, aquatic habitats in the area have been studied separately; however, recent collections of B. nasutus snails and shells indicated that...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182006001594
更新日期:2007-05-01 00:00:00
abstract::Pinewood nematode, Bursaphelenchus xylophilus, a pine parasitic nematode, poses a serious threat to its host pine forests globally. When dispersal-stage larvae 4 (dauer, DL4) of B. xylophilus enters the new pine, it moults into propagative adult (dauer recovery) and reproduces quickly to kill the host pine. Here, we f...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182019001264
更新日期:2020-01-01 00:00:00
abstract::The genetic basis of virulence in a line (YM) of Plasmodium yoelii yoelii was investigated in a cross with a mild line (A/C). The blood forms of the virulent line developed extensively in mature erythrocytes of mice, causing death of the host within 7 days; infections with the mild line were normally restricted to ret...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000048484
更新日期:1976-04-01 00:00:00
abstract::A dipstick dot ELISA for detection of Taenia-specific coproantigens was developed. The test was based on a sandwich ELISA using antibodies raised against adult Taenia solium. Antibodies were absorbed to nitrocellulose paper previously adhered to acetate plastic to form dipsticks. Once blocked with 5% skimmed milk and ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000079439
更新日期:1993-07-01 00:00:00
abstract::African sleeping sickness is a parasitic disease transmitted through the bites of tsetse flies of the genus Glossina. We constructed mechanistic models for the basic reproduction number, R0, of Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, respectively the causative agents of West and East African h...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182010001496
更新日期:2011-04-01 00:00:00