The epigenetic regulation of centromeres and telomeres in plants and animals.

Abstract:

:The centromere is a chromosomal region where the kinetochore is formed, which is the attachment point of spindle fibers. Thus, it is responsible for the correct chromosome segregation during cell division. Telomeres protect chromosome ends against enzymatic degradation and fusions, and localize chromosomes in the cell nucleus. For this reason, centromeres and telomeres are parts of each linear chromosome that are necessary for their proper functioning. More and more research results show that the identity and functions of these chromosomal regions are epigenetically determined. Telomeres and centromeres are both usually described as highly condensed heterochromatin regions. However, the epigenetic nature of centromeres and telomeres is unique, as epigenetic modifications characteristic of both eu- and heterochromatin have been found in these areas. This specificity allows for the proper functioning of both regions, thereby affecting chromosome homeostasis. This review focuses on demonstrating the role of epigenetic mechanisms in the functioning of centromeres and telomeres in plants and animals.

journal_name

Comp Cytogenet

journal_title

Comparative cytogenetics

authors

Achrem M,Szućko I,Kalinka A

doi

10.3897/CompCytogen.v14i2.51895

subject

Has Abstract

pub_date

2020-07-07 00:00:00

pages

265-311

issue

2

eissn

1993-0771

issn

1993-078X

pii

51895

journal_volume

14

pub_type

杂志文章,评审