Abstract:
PURPOSE:High resolution three-dimensional (3D) magnetic resonance (MR) images are well suited for automated cartilage segmentation in the human knee joint. However, volumetric scans such as 3D Double-Echo Steady-State (DESS) images are not routinely acquired in clinical practice which limits opportunities for reliable cartilage segmentation using (fully) automated algorithms. In this work, a method for generating synthetic 3D MR (syn3D-DESS) images with better contrast and higher spatial resolution from routine, low resolution, two-dimensional (2D) Turbo-Spin Echo (TSE) clinical knee scans is proposed. METHODS:A UNet convolutional neural network is employed for synthesizing enhanced artificial MR images suitable for automated knee cartilage segmentation. Training of the model was performed on a large, publically available dataset from the OAI, consisting of 578 MR examinations of knee joints from 102 healthy individuals and patients with knee osteoarthritis. RESULTS:The generated synthetic images have higher spatial resolution and better tissue contrast than the original 2D TSE, which allow high quality automated 3D segmentations of the cartilage. The proposed approach was evaluated on a separate set of MR images from 88 subjects with manual cartilage segmentations. It provided a significant improvement in automated segmentation of knee cartilages when using the syn3D-DESS images compared to the original 2D TSE images. CONCLUSION:The proposed method can successfully synthesize 3D DESS images from 2D TSE images to provide images suitable for automated cartilage segmentation.
journal_name
Med Physjournal_title
Medical physicsauthors
Neubert A,Bourgeat P,Wood J,Engstrom C,Chandra SS,Crozier S,Fripp Jdoi
10.1002/mp.14421subject
Has Abstractpub_date
2020-10-01 00:00:00pages
4939-4948issue
10eissn
0094-2405issn
2473-4209journal_volume
47pub_type
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