Abstract:
:A method for extracting the dark-field signal in propagation-based phase-contrast imaging is proposed. In the case of objects consisting predominantly of a single material, or several different materials with similar ratios of the real decrement to the imaginary part of the complex refractive index, the proposed method requires a single image for extraction of the dark-field signal in two-dimensional projection imaging. In the case of three-dimensional tomographic imaging, the method needs only one image to be collected at each projection angle. Initial examples using simulated and experimental data indicate that this method can improve visualization of small sharp features inside a larger object, e.g. the visualization of microcalcifications in propagation-based x-ray breast cancer imaging. It is suggested that the proposed approach may be useful in other forms of biomedical imaging, where it can help one to obtain additional small-angle scattering information without increasing the radiation dose to the sample.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Gureyev TE,Paganin DM,Arhatari B,Taba ST,Lewis S,Brennan PC,Quiney HMdoi
10.1088/1361-6560/abac9dsubject
Has Abstractpub_date
2020-11-17 00:00:00pages
215029issue
21eissn
0031-9155issn
1361-6560journal_volume
65pub_type
杂志文章abstract::Corrections for room scatter, [ksc(d, H)]RM, were derived using Monte Carlo methods for rooms of various sizes, including the brachytherapy treatment room, in which primary air kerma strength standardization of a remote afterloading microSelectron 192Ir HDR source was carried out, using a 60 cm3 spherical graphite ion...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/46/9/303
更新日期:2001-09-01 00:00:00
abstract::Oxygen ([Formula: see text]) ions are a potential alternative to carbon ions in ion beam therapy. Their enhanced linear energy transfer indicates a higher relative biological effectiveness and a reduced oxygen enhancement ratio. Due to the limited availability of [Formula: see text] ion beams, Monte Carlo (MC) transpo...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa807e
更新日期:2017-09-05 00:00:00
abstract::Talbot-Lau interferometry (TLI) provides additional contrast modes for x-ray imaging that are complementary to conventional absorption radiography. TLI is particularly interesting because it is one of the few practical methods for realizing phase contrast with x-rays that is compatible with large-spot high power x-ray...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab6578
更新日期:2020-02-04 00:00:00
abstract::Several types of intravascular ultrasound (IVUS) catheters are connected to a motor at their proximal end, in order to let the catheter rotate around its length axis. However, the rotation of the distal axis tip does not follow exactly the rotation of the motor, since the catheter axis is not completely torsion-free a...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/43/5/001
更新日期:1998-05-01 00:00:00
abstract::The use of deformable image registration methods in the context of adaptive radiotherapy leads to uncertainties in the simulation of the administered dose distributions during the treatment course. Evaluation of these methods is a prerequisite to decide if a plan adaptation will improve the individual treatment. Curre...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa69b6
更新日期:2017-06-21 00:00:00
abstract::Monte Carlo simulation was used to calculate correction factors for output factor (OF), percentage depth-dose (PDD), and off-axis ratio (OAR) measurements with the CyberKnife M6 System. These include the first such data for the InCise MLC. Simulated detectors include diodes, air-filled microchambers, a synthetic micro...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa5610
更新日期:2017-02-07 00:00:00
abstract::A computer method has been developed which uses the time domain finite-difference (TDFD) algorithm to calculate the deposition of the electromagnetic (EM) field in three-dimensional biological models. This, the first of two papers, describes the algorithm and the computer programs developed. The method is demonstrated...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/31/11/006
更新日期:1986-11-01 00:00:00
abstract::Imaging technologies that allow non-radiative visualization and quantification of apoptosis have a great potential for assessing therapy response, early diagnosis, and disease monitoring. Magnetic particle imaging (MPI), the direct imaging of magnetic nanoparticles as positive contrast agent and sole signal source, en...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/abad7c
更新日期:2020-09-24 00:00:00
abstract::It was observed that the radiation output of x-ray tubes falls off exponentially during an exposure with a time constant of about 120 ms. The equilibrium value is approximately 15% lower than that at the beginning of the exposure. The clinically noticeable consequences are discrepancies in x-ray generator calibration,...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/25/2/004
更新日期:1980-03-01 00:00:00
abstract::In positron emission tomography (PET) with pixelated detectors, a significant number of annihilation photons interact with scintillation crystals through single or multiple Compton scattering events. When these partial energy depositions occur across multiple crystal elements, we call them inter-crystal scatter (ICS) ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aba8b4
更新日期:2020-10-21 00:00:00
abstract::Optical topography is a method for visualization of conical activity. Ways of improving the spatial resolution of the topographical image with three arrangements of optical fibres are discussed. A distribution of sensitivity is obtained from the phantom experiment, and used to reconstruct topographical images of an ac...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/47/18/311
更新日期:2002-09-21 00:00:00
abstract::The purpose of this study is the analysis of the influence of anisotropic conductivity on magnetic fields and electric potentials by means of phantom measurements. An artificial rotating current dipole was placed in the middle of an anisotropic skein arrangement in a torso phantom filled with saline solution. The sign...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/53/1/017
更新日期:2008-01-07 00:00:00
abstract::Values of the relative permittivity and conductivity of the rabbit retina and lens have been measured between 10 MHz and 10 GHz over the temperature range 20 to -20 degrees C. As the temperature was lowered from 20 degrees C the dielectric parameters changed smoothly until -9 degrees C where freezing occurred. At this...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/30/9/009
更新日期:1985-09-01 00:00:00
abstract::Although x-ray mammography is widely developed for breast tumour detection, it suffers from spatial superposition in its two-dimensional (2D) representation of a three-dimensional (3D) breast structure. Accordingly, 3D breast imaging, such as cone-beam computed tomography (CT), arises at the historic moment. In this p...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/48/14/312
更新日期:2003-07-21 00:00:00
abstract::Ho-166 is a combined beta-gamma emitter of which the betas can be used therapeutically. From the 81 keV gammas of Ho-166, SPECT images can be obtained, which give opportunities to guide Ho-166 therapy. Accurate reconstruction of Ho-166 images is currently hampered by photopeak-scatter in the patient, down-scatter in t...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/51/19/004
更新日期:2006-10-07 00:00:00
abstract::Numerous studies of early-stage breast cancer treated with breast conserving surgery (BCS) and radiotherapy (RT) have been published in recent years. Both external beam radiotherapy (EBRT) and/or brachytherapy (BT) with different fractionation schemes are currently used. The present RT practice is largely based on emp...
journal_title:Physics in medicine and biology
pub_type: 杂志文章,meta分析
doi:10.1088/0031-9155/48/20/004
更新日期:2003-10-21 00:00:00
abstract::This work aims to investigate the dosimetric impact of dental implants on volumetric modulated arc therapy (VMAT) for head-and-neck patients and to evaluate the effectiveness of using the material's electron-density ratio for the correction. An in-house Monte Carlo (MC) code was utilized for the dose calculation to ac...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/4/1027
更新日期:2013-02-21 00:00:00
abstract::Fluorescence diffuse optical tomography (fDOT) provides 3D images of fluorescence distributions in biological tissue, which represent molecular and cellular processes. The image reconstruction problem is highly ill-posed and requires regularisation techniques to stabilise and find meaningful solutions. Quadratic regul...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/61/4/1452
更新日期:2016-02-21 00:00:00
abstract::There is a need to verify the accuracy of general purpose Monte Carlo codes like EGSnrc, which are commonly employed for investigations of dosimetric problems in radiation therapy. A number of experimental benchmarks have been published to compare calculated values of absorbed dose to experimentally determined values....
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/19/7637
更新日期:2015-10-07 00:00:00
abstract::The results of optimization of inverse treatment plans depend on a choice of the objective function. Even when the optimal solution for a given cost function can be obtained, a better solution may exist for a given clinical scenario and it could be obtained with a revised objective function. In the approach presented ...
journal_title:Physics in medicine and biology
pub_type: 临床试验,杂志文章
doi:10.1088/0031-9155/49/12/003
更新日期:2004-06-21 00:00:00
abstract::Conventional molecular assessment of tissue through histology, if adapted to fresh thicker samples, has the potential to enhance cancer detection in surgical margins and monitoring of 3D cell culture molecular environments. However, in thicker samples, substantial background staining is common despite repeated rinsing...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa6cf1
更新日期:2017-06-21 00:00:00
abstract::Spinal screw placement is a challenging task due to small bone corridors and high risk of neurological or vascular complications, benefiting from precision guidance/navigation and quality assurance (QA). Implicit to both guidance and QA is the definition of a surgical plan-i.e. the desired trajectories and device sele...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa5f42
更新日期:2017-04-07 00:00:00
abstract::We have developed an impedance magnetocardiogram (IMCG) system to detect the change of magnetic field corresponding to changes in blood volume in the heart. A low magnetic field from the electrical activity of the human heart--the so-called magnetocardiogram (MCG)--can be simultaneously detected by using this system. ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/46/2/403
更新日期:2001-02-01 00:00:00
abstract::A computerized system for monitoring dose-area product (DAP) has been developed for region of interest (ROI) fluoroscopy in which patient exposure is reduced using an x-ray attenuating filter with an aperture. The system includes an IBM compatible computer which is connected through an IEEE-488 interface to an electro...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/42/4/001
更新日期:1997-04-01 00:00:00
abstract::Quality control (QC) data of radiotherapy linear accelerators, collected by Helsinki University Central Hospital between the years 2000 and 2004, were analysed. The goal was to provide information for the evaluation and elaboration of QC of accelerator outputs and to propose a method for QC data analysis. Short- and l...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/51/14/020
更新日期:2006-07-21 00:00:00
abstract::We propose a regularized least-squares method for reconstructing 2D velocity vector fields within the left ventricular cavity from single-view color Doppler echocardiographic images. Vector flow mapping is formulated as a quadratic optimization problem based on an [Formula: see text]-norm minimization of a cost functi...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa7fe7
更新日期:2017-08-11 00:00:00
abstract::The problem of fluorescence diffuse optical tomography consists in localizing fluorescent markers from near-infrared light measurements. Among the different available acquisition modalities, the time-resolved modality is expected to provide measurements of richer information content. To extract this information, the m...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/54/23/004
更新日期:2009-12-07 00:00:00
abstract::This paper reports an inverse arc-modulated radiation therapy planning technique based on linear models. It is implemented with a two-step procedure. First, fluence maps for 36 fixed-gantry beams are generated using a linear model-based intensity-modulated radiation therapy (IMRT) optimization algorithm. The 2D fluenc...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/55/13/020
更新日期:2010-07-07 00:00:00
abstract::Picking geometrically relevant atlases from the whole training set is crucial to multi-atlas based image segmentation, especially with extensive data of heterogeneous quality in the Big Data era. Unfortunately, there is very limited understanding of how currently used image similarity criteria reveal geometric relevan...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/61/11/4223
更新日期:2016-06-07 00:00:00
abstract::In critical organ in vivo x-ray dosimetry, the relative contaminating electron contribution to the total dose and total detector response outside the field will be different to the corresponding contributions at the central axis detector calibration position, mainly due to the effects of shielding in the linear accele...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/51/24/013
更新日期:2006-12-21 00:00:00