Neuropathologic and Cognitive Correlates of Enlarged Perivascular Spaces in a Community-Based Cohort of Older Adults.

abstract：BACKGROUND AND PURPOSE:Multimodal CT imaging consisting of nonenhanced CT, CT angiography (CTA), and whole-brain volume perfusion CT is increasingly used for acute stroke imaging. In these patients, presence of vessel occlusion is an important factor governing treatment decisions and possible endovascular therapy. The ...

journal_title：Stroke

authors： Frölich AM,Psychogios MN,Klotz E,Schramm R,Knauth M,Schramm P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Milk fat globule-EGF factor-8 (MFGE8) has been reported to be neuroprotective in ischemic stroke. However, the effects of MFGE8 in early brain injury after subarachnoid hemorrhage (SAH) have not been investigated. We investigated the role of MFGE8 in early brain injury and the potential mechanism...

journal_title：Stroke

authors： Liu F,Hu Q,Li B,Manaenko A,Chen Y,Tang J,Guo Z,Tang J,Zhang JH

更新日期：2014-12-01 00:00:00

abstract：:Background and Purpose- Cerebral small vessel disease (SVD) is associated with increased stroke risk and poor stroke outcomes. We aimed to evaluate whether chronic SVD burden is associated with poor recruitment of collaterals in large-vessel occlusive stroke. Methods- Consecutive patients with middle cerebral artery o...

journal_title：Stroke

authors： Lin MP,Brott TG,Liebeskind DS,Meschia JF,Sam K,Gottesman RF

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...

journal_title：Stroke

authors： Husemann B,Müller F,Krewer C,Heller S,Koenig E

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of our study was to characterize the patient profile and prognostic value associated with high positive IgG (>100 GPL) anticardiolipin antibodies (aCL). METHODS:We studied the clinical, laboratory, radiological, and prospective historical features of ischemic cerebrovascular disease in p...

journal_title：Stroke

authors： Verro P,Levine SR,Tietjen GE

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Reports of ischemic stroke affecting the hippocampus are rare. In this study we used diffusion-weighted MRI (DWI) to characterize patients with posterior circulation stroke involving the hippocampus. METHODS:Fifty-seven consecutive acute stroke patients with hippocampal infarct (HI) on DWI were ...

journal_title：Stroke

authors： Szabo K,Förster A,Jäger T,Kern R,Griebe M,Hennerici MG,Gass A

更新日期：2009-06-01 00:00:00

abstract：:Occlusion of the anterior cerebral artery is a rare condition. A review of CT scans from 413 patients with ischemic infarction confirmed this low relative incidence: only 3% of CT scans evidencing infarction involved the territory of the anterior cerebral artery. Four major mechanisms of anterior cerebral artery occlu...

journal_title：Stroke

authors： Gacs G,Fox AJ,Barnett HJ,Vinuela F

更新日期：1983-11-01 00:00:00

abstract：:Regional cerebral ischemia was produced by common carotid artery occlusion in gerbils and by middle cerebral artery occlusion in dogs, cats, and squirrel monkeys. Anesthesia was induced with either pentobarbital or halothane and maintained for two to three hours after vessel occlusion. In acute studies, the effect of ...

journal_title：Stroke

authors： Michenfelder JD,Milde JH

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS:Transient ischemia was induced by occluding both common...

journal_title：Stroke

authors： Yamashita K,Eguchi Y,Kajiwara K,Ito H

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transcranial Doppler ultrasound can detect circulating cerebral emboli. Monitoring of patients with potential embolic sources may allow identification of high-risk patients who can then be selected for prophylactic treatment. However, practical patient monitoring will require automated programs t...

journal_title：Stroke

authors： Markus H,Loh A,Brown MM

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Systemic inflammatory response syndrome (SIRS) is a generalized inflammatory state. The primary goal of the study was to determine whether differences exist in outcomes in SIRS and non-SIRS intravenous tissue-type plasminogen activator-treated patients. METHODS:Consecutive patients were retrospe...

journal_title：Stroke

authors： Boehme AK,Kapoor N,Albright KC,Lyerly MJ,Rawal PV,Bavarsad Shahripour R,Alvi M,Houston JT,Sisson A,Beasley TM,Alexandrov AW,Alexandrov AV,Miller DW

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Short-term elevations in fine particulate matter air pollution (PM2.5) are associated with increased risk of acute cerebrovascular events. Evidence from the peripheral circulation suggests that vascular dysfunction may be a central mechanism. However, the effects of PM2.5 on cerebrovascular funct...

journal_title：Stroke

authors： Wellenius GA,Boyle LD,Wilker EH,Sorond FA,Coull BA,Koutrakis P,Mittleman MA,Lipsitz LA

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear. METHODS:This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of as...

journal_title：Stroke

authors： Amarenco P,Davis S,Jones EF,Cohen AA,Heiss WD,Kaste M,Laouénan C,Young D,Macleod M,Donnan GA,Aortic Arch Related Cerebral Hazard Trial Investigators.

更新日期：2014-05-01 00:00:00

abstract：:Background and Purpose- Although obesity is an established risk factor for cardiovascular disease and stroke, studies have shown evidence of an obesity paradox-a protective effect of obesity in patients who already have these disease states. Data on the obesity paradox in intracerebral hemorrhage is limited. Methods- ...

journal_title：Stroke

authors： Persaud SR,Lieber AC,Donath E,Stingone JA,Dangayach NS,Zhang X,Mocco J,Kellner CP

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vertebrobasilar territory ischemia (VBI) leads to disabling neurological symptoms and poses a risk for stroke by an embolic or flow-related mechanism. We present our clinical experience in the endovascular treatment of patients with symptomatic VBI from severe atherosclerosis or dissection of the...

journal_title：Stroke

authors： Malek AM,Higashida RT,Phatouros CC,Lempert TE,Meyers PM,Gress DR,Dowd CF,Halbach VV

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to demonstrate the contribution of axonal remodeling of the corticospinal tract (CST) in the spinal cord to functional outcome after stroke. METHODS:Bilateral pyramidotomy (BPT) or sham-BPT was performed in mice with transgenic yellow fluorescent protein labeling in the CST subjected t...

journal_title：Stroke

authors： Liu Z,Chopp M,Ding X,Cui Y,Li Y

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Release of excitatory amino acids (EAA) is considered a cause of neuronal damage in ischemia. We investigated the sources and mechanisms of EAA release using microdialysis in regions of incomplete ischemia where perfusion was reduced by 50% to 80%, by applying inhibitors of volume-regulated anion...

journal_title：Stroke

authors： Feustel PJ,Jin Y,Kimelberg HK

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Close relations between leukoaraiosis detected by computed tomography or magnetic resonance imaging and stroke, particularly lacunar infarction, have been reported. We studied whether leukoaraiosis is related to long-term prognosis for patients with lacunar infarction. METHODS:We examined monthl...

journal_title：Stroke

authors： Miyao S,Takano A,Teramoto J,Takahashi A

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is debate regarding the approach for analysis of modified Rankin scale scores, the most common functional outcome scale used in acute stroke trials. METHODS:We propose to use tests to assess treatment differences addressing the metric, "if a patient is chosen at random from each treatment ...

journal_title：Stroke

authors： Howard G,Waller JL,Voeks JH,Howard VJ,Jauch EC,Lees KR,Nichols FT,Rahlfs VW,Hess DC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke unit care is one of the most powerful interventions available to help stroke patients. There are limited data available to assess the impact of stroke units in routine clinical practice outside randomized clinical trials. This article uses data from the 2001 to 2002 National Stroke Audit t...

journal_title：Stroke

authors： Rudd AG,Hoffman A,Irwin P,Lowe D,Pearson MG

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of the present study was to investigate cerebral hemodynamics in patients requiring surgical treatment for lobar intracerebral hemorrhage. METHODS:Twenty patients who underwent surgery to remove a lobar spontaneous intracerebral hemorrhage were scanned before and after surgery using perf...

journal_title：Stroke

authors： Etminan N,Beseoglu K,Turowski B,Steiger HJ,Hänggi D

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Therapeutic temperature modulation is widely used in neurocritical care but commonly causes shivering, which can hamper the cooling process and result in increases in systemic metabolism. We sought to validate a grading scale to assist in the monitoring and control of shivering. METHODS:A simple...

journal_title：Stroke

authors： Badjatia N,Strongilis E,Gordon E,Prescutti M,Fernandez L,Fernandez A,Buitrago M,Schmidt JM,Ostapkovich ND,Mayer SA

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory mechanisms can exacerbate ischemic tissue damage and worsen clinical outcome in patients with stroke. Both αβ and γδ T cells are established mediators of tissue damage in stroke, and the role of dendritic cells (DCs) in inducing the early events of T cell activation and differentiati...

journal_title：Stroke

authors： Gelderblom M,Gallizioli M,Ludewig P,Thom V,Arunachalam P,Rissiek B,Bernreuther C,Glatzel M,Korn T,Arumugam TV,Sedlacik J,Gerloff C,Tolosa E,Planas AM,Magnus T

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid plaque composition is a major determinant of cerebrovascular events. In the present analysis, we evaluated the relationship between intraplaque hemorrhage (IPH) and a thin/ruptured fibrous cap (TRFC) in moderately stenosed carotid arteries and cerebral infarcts on MRI in the ipsilateral h...

journal_title：Stroke

authors： de Rotte AA,Truijman MT,van Dijk AC,Liem MI,Schreuder FH,van der Kolk AG,de Kruijk JR,Daemen MJ,van der Steen AF,de Borst GJ,Luijten PR,Nederkoorn PJ,Kooi ME,van der Lugt A,Hendrikse J

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The pathophysiology of borderzone infarcts is not well understood. We investigated whether combined diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) could identify pathophysiologically meaningful categories of borderzone infarcts. METHODS:Seventeen patients with borderzone i...

journal_title：Stroke

authors： Chaves CJ,Silver B,Schlaug G,Dashe J,Caplan LR,Warach S

更新日期：2000-05-01 00:00:00

abstract：:I provide the theoretical basis for an error calculus for measurements of cerebral blood flow using a freely diffusible tracer substance such as xenon-133. The use of the error calculus is exemplified by a study of the effect on the error margins in measurements of gray matter blood flow from flow level, relative weig...

journal_title：Stroke

authors： Ryding E

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic postconditioning, a brief episode of ischemia after a prolonged ischemic insult, has been found to reduce the delayed neuronal loss after stroke. However, the mechanisms underlying such endogenous neuroprotective strategy remain obscure. In this study, we try to explore the excitatory po...

journal_title：Stroke

authors： Liu J,Xu Q,Wang H,Wang R,Hou XY

更新日期：2013-07-01 00:00:00

abstract：:Nineteen unanesthetized sheep were given Evans blue dye or radionuclide and then were incrementally bled into hemorrhagic shock (BP less than 50/25) by withdrawal of blood over a period of approximately one hour. Four sheep served as controls for histologic data. Static nuclide brain scans performed in 6 bled sheep d...

journal_title：Stroke

authors： Bronshvag MM

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...

journal_title：Stroke

authors： Chen CH,Toung TJ,Hurn PD,Koehler RC,Bhardwaj A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Numerous studies have demonstrated an association between acute cardiac events, cerebrovascular accidents, and cocaine use. The underlying mechanisms leading to these complications have not been well defined. Using various in vitro model systems, it has been reported that cocaine, up to or greate...

journal_title：Stroke

authors： Jennings LK,White MM,Sauer CM,Mauer AM,Robertson JT

更新日期：1993-09-01 00:00:00