Abstract:
BACKGROUND/OBJECTIVES:This study investigates correlations between circulating microRNAs (miRNAs) and obesity-related parameters among young women (aged 20-30 years old) in Korea. SUBJECTS/METHODS:We analyzed TaqMan low density arrays (TLDAs) of circulating miRNAs in 9 lean (body mass index [BMI] < 25 kg/m2) and 15 obese (BMI > 25 kg/m2) women. We also performed gene ontology (GO) analyses of the biological functions of predicted miRNA target genes, and clustered the results using the database for annotation, visualization and integrated discovery. RESULTS:The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR-144-5p, miR-192, miR-320, miR-320b, miR-484, miR-324-3p, and miR-378. Among them, miR-484 and miR-378 displayed the most significant inverse correlations with BMI (miR-484, r = -0.5484, P = 0.0056; miR-378, r = -0.5538, P = 0.0050) and visceral fat content (miR-484, r = -0.6141, P = 0.0014; miR-378, r = -0.6090, P = 0.0017). GO analysis indicated that genes targeted by miR-484 and miR-378 had major roles in carbohydrate and lipid metabolism. CONCLUSION:Our result showed the differentially expressed circulating miRNAs in obese subjects compared to lean subjects. Although the mechanistic study to reveal the causal role of miRNAs remains, these miRNAs may be novel biomarkers for obesity.
journal_name
Nutr Res Practjournal_title
Nutrition research and practiceauthors
Choi WH,Ahn J,Um MY,Jung CH,Jung SE,Ha TYdoi
10.4162/nrp.2020.14.4.412subject
Has Abstractpub_date
2020-08-01 00:00:00pages
412-422issue
4eissn
1976-1457issn
2005-6168journal_volume
14pub_type
杂志文章abstract::Zinc is an essential trace element required for bone formation, however not much has been clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic function in osteoblasts. To test this, we investigated whether zinc treatment enhances bone formation by stimulating osteoblast proli...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.5.356
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abstract::This study investigated the effect of physical training and oxidative stress on the antioxidative activity and on plasma lipid profile. Forty eight rats were given either a physical training or no training for 4 weeks and were then subdivided into 3 groups: before-exercise (BE); during-exercise (DE); after-exercise (A...
journal_title:Nutrition research and practice
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abstract:BACKGROUND/OBJECTIVES:Over the past few decades, Malaysia has been experiencing an increased prevalence of overweight and obesity that threatens the health of Malaysians. Poor dietary intake is one of the major contributors to the development of obesity and many non-communicable diseases. The dietary intakes of adults ...
journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2020.14.1.20
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journal_title:Nutrition research and practice
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doi:10.4162/nrp.2017.11.4.334
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abstract::This study was to investigate utilization status of internet, health/nutrition websites among children, and to assess the needs for developing nutrition websites and education programs for children. The survey questionnaire was administered to 5-6th grade students (n=434) at two elementary schools. About 32% used the ...
journal_title:Nutrition research and practice
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doi:10.4162/nrp.2007.1.4.341
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journal_title:Nutrition research and practice
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doi:10.4162/nrp.2011.5.4.349
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2011.5.1.73
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2017.11.5.430
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journal_title:Nutrition research and practice
pub_type: 杂志文章
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2020.14.5.501
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.1.81
更新日期:2014-02-01 00:00:00
abstract::Dietary sodium intake is considered one of the major causal factors for hypertension. Thus, to control the increase of blood pressure and reduce the risk of hypertension-related clinical complications, a reduction in sodium intake is recommended. The present study aimed at determining the association of dietary sodium...
journal_title:Nutrition research and practice
pub_type: 杂志文章
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journal_title:Nutrition research and practice
pub_type: 杂志文章
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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doi:10.4162/nrp.2018.12.3.243
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.1.58
更新日期:2010-02-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.6.695
更新日期:2014-12-01 00:00:00
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journal_title:Nutrition research and practice
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doi:10.4162/nrp.2014.8.3.336
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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doi:10.4162/nrp.2012.6.6.505
更新日期:2012-12-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2009.3.1.38
更新日期:2009-04-01 00:00:00
abstract::The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 ± 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL partic...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.2.120
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Serum ferritin levels are significantly increased after menopause and greatly affect women's health. The aim of this study was to investigate the dietary and non-dietary factors associated with high ferritin levels in postmenopausal women. SUBJECTS/METHODS:Among adult women in 2010-2012, qualifie...
journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.5.400
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journal_title:Nutrition research and practice
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更新日期:2018-04-01 00:00:00