Abstract:
OBJECTIVES:A systematic review and meta analysis using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach. The aim was to evaluate the efficacy of Botulinum Toxin type A for limb spasticity on improving activity restriction and quality of life outcomes. DATA SOURCES:Pubmed, Cinahl, Amed, Embase and Cochrane databases. English Language. Search to January 2015. REVIEW METHODS:All randomized, placebo controlled trials on adults with active function or quality of life measures for the arm and leg relating to spasticity of any origin and treated with a single dose of Botulinum Toxin A. Evidence quality was assessed by GRADE. RESULTS:Twenty-five studies were reviewed. Meta analysis was carried out on six upper limb and six lower limb studies. Evidence quality for the upper limb was low/very low. A significant result for Botulinum Toxin A was found at four to twelve weeks for the upper limb for active function (SMD 0.32 CI 0.01, 0.62, P=0.04) These effects were maintained for up to six months for Active Research Arm Test (ARAT) only (MD 1.87 CI 0.53, 3.21, P=0.006).Evidence quality was very low for the lower limb. No significant effect was found. Meta analysis was not possible for quality of life measures. CONCLUSION:Botulinum Toxin A may improve active outcomes in the upper limb but further evidence is needed. No conclusion can be drawn about the effect on active outcomes for the lower limb or for quality of life measures in either limb.
journal_name
Clin Rehabiljournal_title
Clinical rehabilitationauthors
Baker JA,Pereira Gdoi
10.1177/0269215515593609subject
Has Abstractpub_date
2016-06-01 00:00:00pages
549-58issue
6eissn
0269-2155issn
1477-0873pii
0269215515593609journal_volume
30pub_type
杂志文章,meta分析,评审abstract:OBJECTIVES:This study hypothesized that higher caregiving demands are related to higher perceived injustice. Furthermore, this study investigated the mediating role of perceived injustice in the link between caregiving demands and caregivers' psychological well-being. DESIGN:A cross-sectional design. SETTING:The Pain...
journal_title:Clinical rehabilitation
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To explore constructs relevant to self-efficacy in neurological rehabilitation. DESIGN:Qualitative methods using semi-structured interviews. SETTING:Specialist neurological rehabilitation unit, Liverpool, UK. SUBJECTS:Twenty-four patients (12 male) with experience of inpatient rehabilitation, aged 17-59 (m...
journal_title:Clinical rehabilitation
pub_type: 杂志文章
doi:10.1177/0269215506071784
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abstract:OBJECTIVE:To assess the process of hospital-based stroke rehabilitation. DESIGN:A criterion-based process audit, combined with surveys of patient and staff opinions and basic outcome measures. SETTING:All wards and units treating stroke patients in a health care district, including an acute and a community National H...
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doi:10.1191/026921599674794965
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pub_type: 杂志文章,meta分析
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更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of diacutaneous fibrolysis in reducing musculoskeletal disorders symptoms such as pain, range of motion and functionality. DATA SOURCES:A systematic review of MEDLINE, Cochrane, PEDro and Science Direct was conducted until September 2020. REVIEW METHODS:Computerized search strate...
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journal_title:Clinical rehabilitation
pub_type: 杂志文章
doi:10.1191/0269215505cr783oa
更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Clinical rehabilitation
pub_type: 杂志文章
doi:10.1177/0269215507077286
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:Constraint-induced movement therapy (CIMT) is a method to improve motor function in the upper extremity following stroke. The aim of this trial was to determine the effect and feasibility of CIMT compared with traditional rehabilitation in short and long term. DESIGN:A randomized controlled trial. SETTING:A...
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To evaluate evidence on the effectiveness of Mulligan techniques on low back pain. DATA SOURCES:PubMed/Medline, Scopus, Ovid, CINAHL, Embase, PEDro, Google Scholar, and Cochrane Library were searched from inception to 31 March 2018 for randomized clinical trials reporting outcomes of pain or disability in ad...
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更新日期:2018-10-01 00:00:00
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-11-01 00:00:00
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2009-03-01 00:00:00
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更新日期:2015-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-10-01 00:00:00
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更新日期:2006-02-01 00:00:00
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更新日期:2014-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-08-01 00:00:00
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更新日期:2018-12-01 00:00:00
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更新日期:2020-06-01 00:00:00
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更新日期:2016-07-01 00:00:00
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更新日期:2016-05-01 00:00:00