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Characterization of tissue-specific pre-log Bayesian CT reconstruction by texture-dose relationship.

Abstract：

PURPOSE:Tissue textures have been recognized as biomarkers for various clinical tasks. In computed tomography (CT) image reconstruction, it is important but challenging to preserve the texture when lowering x-ray exposure from full- toward low-/ultra-low dose level. Therefore, this paper aims to explore the texture-dose relationship within one tissue-specific pre-log Bayesian CT reconstruction algorithm. METHODS:To enhance the texture in ultra-low dose CT (ULdCT) reconstruction, this paper presents a Bayesian type algorithm. A shifted Poisson model is adapted to describe the statistical properties of pre-log data, and a tissue-specific Markov random field prior (MRFt) is used to incorporate tissue texture from previous full-dose CT, thus called SP-MRFt algorithm. Utilizing the SP-MRFt algorithm, we investigated tissue texture degradation as a function of x-ray dose levels from full dose (100 mAs/120 kVp) to ultralow dose (1 mAs/120 kVp) by using quantitative texture-based evaluation metrics. RESULTS:Experimental results show the SP-MRFt algorithm outperforms conventional filtered back projection (FBP) and post-log domain penalized weighted least square MRFt (PWLS-MRFt) in terms of noise suppression and texture preservation. Comparable results are also obtained with shifted Poisson model with 7 × 7 Huber MRF weights (SP-Huber7). The investigation on texture-dose relationship shows that the quantified texture measures drop monotonically as dose level decreases, and interestingly a turning point is observed on the texture-dose response curve. CONCLUSIONS:This important observation implies that there exists a minimum dose level, at which a given CT scanner (hardware configuration and image reconstruction software) can achieve without compromising clinical tasks. Moreover, the experiment results show that the variance of electronic noise has higher impact than the mean to the texture-dose relationship.

journal_name

Med Phys

journal_title

Medical physics

authors

Gao Y,Liang Z,Xing Y,Zhang H,Pomeroy M,Lu S,Ma J,Lu H,Moore W

doi

10.1002/mp.14449

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

5032-5047

issue

eissn

0094-2405

issn

2473-4209

journal_volume

pub_type

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Characterization of tissue-specific pre-log Bayesian CT reconstruction by texture-dose relationship.