Assessing and mitigating the interference of ALX148, a novel CD47 blocking agent, in pretransfusion compatibility testing.

abstract：:Antiglobulin sera from nine different manufacturers have been tested, over a two-year period, for their ability to detect the complement components beta 1A, alpha 2D, and beta 1E. The results demontrate considerable variation in the abilities of sera from different manufacturers to detect these components and indicate...

journal_title：Transfusion

authors： Issitt PD,Issitt CH,Wilkinson SL

更新日期：1974-03-01 00:00:00

abstract：BACKGROUND:Acoustic cell separation uses ultrasound waves to separate cells from plasma to perform plasmapheresis. Although the fundamental process has been studied for decades, no acoustic cell separation has been studied in a disposable plastic format suitable for clinical applications. STUDY DESIGN AND METHODS:We d...

journal_title：Transfusion

authors： Savage WJ,Burns JR,Fiering J

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The FUT2 gene regulates the expression of ABH antigens in body secretions and hence controls the secretor status. It is highly polymorphic. STUDY DESIGN AND METHODS:Healthy Chinese (n = 79) and Caucasian (n = 20) subjects were recruited for this study. Lewis blood group and secretor status were determined. ...

journal_title：Transfusion

authors： Yip SP,Lai SK,Wong ML

更新日期：2007-08-01 00:00:00

abstract：:Alanine aminotransferase (ALT) phenotype and serum activities were determined in 200 random volunteer blood donors. Serum enzyme activities were not significantly affected by the ALT phenotype (p greater than 0.1). Studies on 500 random volunteer blood donors showed significant differences in serum ALT levels between ...

journal_title：Transfusion

authors： Savage B,Sayers MH,Giblett ER

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Recently, long-standing elevations of soluble growth factors released from platelets (PLTs) after contact with artificial surfaces during dialysis were described. They could be jointly responsible for the high frequency of death from cardiovascular diseases in dialysis patients. There are no comparable data ...

journal_title：Transfusion

authors： Zimmermann R,Loew D,Weisbach V,Strasser E,Ringwald J,Zingsem J,Eckstein R

更新日期：2005-03-01 00:00:00

abstract：:Red cells (RBCs) prepared by a new system using centrifugation to produce neocyte enrichment were studied in two laboratories. The system used a blood bag with a geometric configuration such that younger, less dense cells could be separated from older, denser cells. Phthalate ester density gradient curves determined t...

journal_title：Transfusion

authors： Simon TL,Sohmer P,Nelson EJ

更新日期：1989-03-01 00:00:00

abstract：:The anti-A response in a group B patient accidentally given 1 unit transfusion of A1 blood is described. The antibody response is characterized both with conventional agglutination techniques and with radioimmunoassay using pure group A antigens with different core saccharide structures (type 1, 2, and 4 chains) and c...

journal_title：Transfusion

authors： Rydberg L,Breimer ME,Samuelsson BE

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Screening of blood donors for antibody to human immunodeficiency virus Types 1 and 2 (anti-HIV-1/2) and/or HIV nucleic acid test (NAT) is a well-established venue to prevent HIV transfusion-transmitted disease. However, with the current available technologies, HIV testing may result in donor loss due to fals...

journal_title：Transfusion

authors： Li L,Xu T,Yang T,Zang L,Cheng W,Lin H,Zhu S,Zhao B,Duan R,Li C,Huang M,Liu Y,Ming C,Xu S,Wang C,Wu Y,Liu Z

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The effect on component wastage after enhancing the clinician's ability to order blood products in the computerized physician order entry (CPOE) system was investigated in a multihospital network. METHODS:A novel field was added to the CPOE of eight hospitals within a health care system allowing the physici...

journal_title：Transfusion

authors： Yazer MH,Deandrade DS,Triulzi DJ,Wisniewski MK,Waters JH

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:In sub-Saharan Africa (SSA) confirmed viral marker prevalence between family donors (FDs) and first-time volunteer nonremunerated donors (VNRDs) is similar. In a blood service collecting 10 units/1000 inhabitants, a questionnaire examined FD donation conditions and willingness of becoming repeat VNRDs. STUD...

journal_title：Transfusion

authors： Asenso-Mensah K,Achina G,Appiah R,Owusu-Ofori S,Allain JP

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate an iodine-based method of activating potentially harmful viruses that might be found in normal human plasma. STUDY DESIGN AND METHODS:A procedure has been developed for inactivating lipid-enveloped and non-lipid-enveloped model viruses in normal human plasma by usin...

journal_title：Transfusion

authors： Highsmith FA,Xue H,Caple M,Walthall B,Drohan WN,Shanbrom E

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:This randomized controlled study was undertaken to determine the effect of recombinant human erythropoietin (rHuEPO) on erythropoiesis, autologous blood collection, and allogeneic transfusion risk in elective surgery patients with low baseline hematocrits. STUDY DESIGN AND METHODS:Patients (n = 204) with lo...

journal_title：Transfusion

authors： Price TH,Goodnough LT,Vogler WR,Sacher RA,Hellman RM,Johnston MF,Bolgiano DC,Abels RI

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:To investigate how a delay between pretransfusion platelet count measurement and actual platelet transfusion affects the assessment of platelet transfusion responses, the rate of reduction in platelet counts was determined in 30 patients with relatively uncomplicated thrombocytopenia. STUDY DESIGN AND METHO...

journal_title：Transfusion

authors： del Rosario ML,Kao KI

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Fetal and neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a more commonly occurs in first pregnancies, unlike hemolytic disease of the newborn. Anti-D is produced after D+ fetomaternal hemorrhage; this usually occurs at parturition. Anti-HPA-1a could develop during pregnancy if...

journal_title：Transfusion

authors： Kumpel BM,Sibley K,Jackson DJ,White G,Soothill PW

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Washing of red blood cell concentrates (RCCs) is required for potassium-sensitive transfusion recipients, including neonates in need of large-volume transfusions. When open, nonsterile washing systems are used, postwash outdate time is limited to 24 hours, often leading to problems providing the component to...

journal_title：Transfusion

authors： Hansen A,Yi QL,Acker JP

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Ultrasound-facilitated delivery of topical anesthetics has been used to achieve effective anesthesia within 5 minutes for venipuncture and the insertion of intravenous access devices, but has never been studied for blood donation. STUDY DESIGN AND METHODS:This study was a single-center, prospective, randomi...

journal_title：Transfusion

authors： Stowell CP,Trieu MQ,Chuang H,Katz N,Quarrington C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Parvovirus B19 (B19) is known to cause a variety of human diseases in susceptible individuals by close contact via the respiratory route or by transfusion of contaminated blood or blood products. In this study, whether a case of B19 transmission was causally related to the infusion of implicated lots of a so...

journal_title：Transfusion

authors： Wu CG,Mason B,Jong J,Erdman D,McKernan L,Oakley M,Soucie M,Evatt B,Yu MY

更新日期：2005-06-01 00:00:00

abstract：:This article introduces a new method of component preparation that is capable of producing white cell (WBC)-reduced platelet concentrates (PCs) from whole blood. Whole blood is separated into packed red cells (RBCs) and platelet-rich plasma (PRP) by centrifugation, and the PRP is expressed through a newly designed WBC...

journal_title：Transfusion

authors： Dzik WH,Cusack WF,Gacek MJ

更新日期：1991-07-01 00:00:00

abstract：:Analysis of blood coagulation was done on samples of blood collected from ten donors undergoing combined platelet and leukapheresis using the Haemonetics Model 30 Blood Processor. Blood samples were obtained from the donors prior to, during, and following pheresis. Blood was also obtained from the blood-return line af...

journal_title：Transfusion

authors： Kisker CT,Strauss RG,Koepke JA,Maguire LC,Thompson JS

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND:Recovery and half-life estimations were carried out to compare a high-purity factor IX concentrate with an established factor IX complex concentrate. STUDY DESIGN AND METHODS:Two high-purity factor IX concentrates, which are identical except for the presence or absence of heparin (Immuninehep-plus and Immun...

journal_title：Transfusion

authors： Poon MC,Aledort LM,Anderle K,Kunschak M,Morfini M

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Commercially available additive solutions (ASs) require 30% to 35% plasma for optimal storage of platelets (PLTs). PLTs suspended in M-sol, a bicarbonate-based experimental platelet additive solution (PAS), maintain in vitro PLT properties during storage with low levels of plasma (< or =5%). STUDY DESIGN AN...

journal_title：Transfusion

authors： Wagner SJ,Skripchenko A,Myrup A,Thompson-Montgomery D,Awatefe H,Moroff G

更新日期：2010-05-01 00:00:00

abstract：:KEY IDEAS Chimeric antigen receptor (CAR) T-cell therapy has the potential to improve the dismal outcome of patients diagnosed with acute myeloid leukemia (AML). A major challenge for CAR T-cell therapy of AML patients is identifying leukemia-specific target antigens. Immune escape through down-regulation of target an...

journal_title：Transfusion

authors： Sauer T,Rooney CM

更新日期：2019-04-01 00:00:00

abstract：:A female patient developed serious hemolysis in association with the injection of a radiographic contrast medium (RCM). Serologic investigation of her serum suggested complement-mediated hemolysis, induced by an RCM-dependent IgM antibody in her serum. The antibody was of high titer and low avidity. The antibody showe...

journal_title：Transfusion

authors： Nordhagen R,Vik H,Wolthuis K,Bøhn HP,Urdahl P,Michaelsen TE

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:The term platelet storage lesion (PSL) describes the structural and biochemical changes in platelets (PLTs) during storage. These are typified by alterations of morphologic features and PLT metabolism leading to reduced functionality and hence reduced viability for transfusion. While the manifestations of th...

journal_title：Transfusion

authors： Schubert P,Thon JN,Walsh GM,Chen CH,Moore ED,Devine DV,Kast J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Demonstration of viable Chlamydia (Chlamydophila) pneumoniae in peripheral blood mononuclear cells (PBMNCs) is essential to understand the involvement of C. pneumoniae in atherosclerosis. Nevertheless, the prevalence of viable C. pneumoniae in the blood of healthy donors has not yet been studied. STUDY DESI...

journal_title：Transfusion

authors： Yamaguchi H,Yamada M,Uruma T,Kanamori M,Goto H,Yamamoto Y,Kamiya S

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Antibodies to Mia , MUT, and Mur are among the most frequently identified alloantibodies in Southeast Asia. Understanding the characteristics of these antibodies in terms of induction and evanescence would aid in optimizing methods for their detection. STUDY DESIGN AND METHODS:Antibody testing results betwe...

journal_title：Transfusion

authors： Nadarajan VS

更新日期：2018-05-01 00:00:00

abstract：:Removal of white cells (WBCs) from platelets may reduce alloimmunization to WBC antigens, prevent febrile reactions, and improve platelet increments in multiply transfused patients receiving HLA-matched platelets. A new surface-modified fibrous polyester filter was evaluated; it requires no special processing of poole...

journal_title：Transfusion

authors： Kickler TS,Bell W,Drew H,Pall D

更新日期：1989-06-01 00:00:00

abstract：:Sterility of blood products is a cardinal contributor to patient safety. Bacteriologic controls of stable products comply with strict regulations, but legislation imposes only limited constraints in the case of perishable products, such as packed red cells (RBCs) or fresh-frozen plasma (FFP). Therefore, it is essentia...

journal_title：Transfusion

authors： Guéguen M,Durand F,Delamaire D,Beauplet A,Tardivel R,Genetet B,Chalumeau H,Balme MC

更新日期：1986-05-01 00:00:00

abstract：:The two-stage method of Pool and Robinson was used in determining plasma Factor VIII activity following contact with four commercially available plastic blood and pooling bag films. Employing a two-arm double plasmapheresis technique, it was shown that Factor VIII activity in whole blood initially drawn into BB-69 and...

journal_title：Transfusion

authors： Mishler JM,Nicora RW,Hamilton JE,Caster G,Kasper CK

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:The objective was to investigate whether women who develop preeclampsia can be identified in a routine analysis when determining fetal RHD status at 25 weeks' gestation in combination with PAPP-A levels at the first-trimester combined risk assessment for Trisomy 21. STUDY DESIGN AND METHODS:D- women partici...

journal_title：Transfusion

authors： Jakobsen TR,Clausen FB,Rode L,Dziegiel MH,Tabor A

更新日期：2013-09-01 00:00:00