Abstract：
BACKGROUND:Despite accumulating data on the pathogenesis of eosinophilic esophagitis, not much is known about risk factors for the development of the disease. The role of factors such as smoking, breastfeeding, early antibiotic exposure and other factors that have been associated with other allergic diseases has not been well studied in children with eosinophilic esophagitis. AIM:To explore the role of environmental and medication exposures in the development of pediatric eosinophilic esophagitis. METHODS:We conducted a cross-sectional case-control study, utilizing a parent and child questionnaire and medical chart review. Urine cotinine levels, measured by high-performance liquid chromatography, were obtained as objective evidence for smoking exposure. RESULTS:One hundred and two children with eosinophilic esophagitis and 167 controls were recruited. The controls were mainly diagnosed with functional gastrointestinal disorders (33%) and gastroesophageal reflux disease (29%). Food allergy, specifically for peanuts and tree nuts, and allergy to pollen, tree, and grass were significantly higher among eosinophilic esophagitis children. Smoking exposure, both primary and secondary, was not associated with pediatric eosinophilic esophagitis when compared to controls (odds ratio 0.96, 95% confidence interval 0.58-1.59). Furthermore, early smoking exposure in the first year of life was higher among controls. Common accepted risk factors for allergy and atopy, such as breastfeeding practices, antibiotics exposure, animals' exposure, and others, were not found to be associated with eosinophilic esophagitis in our study. CONCLUSION:Common risk factors in other allergic and atopic conditions were not found to be associated with eosinophilic esophagitis.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Slae M,Persad R,Leung AJ,Gabr R,Brocks D,Huynh HQdoi
10.1007/s10620-015-3740-7subject
Has Abstractpub_date
2015-11-01 00:00:00pages
3364-72issue
11eissn
0163-2116issn
1573-2568pii
10.1007/s10620-015-3740-7journal_volume
60pub_type
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