Abstract:
Objectives:This study was conducted to determine whether patients with allergy might be more susceptible to human rhinovirus (HRV) infection and whether the effects of infection on the elicited immune responses are different in allergic and non-allergic patients with chronic rhinosinusitis (CRS). Methods:Uncinate process tissues were obtained from 61 chronic rhinosinusitis patients (of which, 39 had allergy and 22 did not) who were infected with HRV16 using an air-liquid interface organ culture system. The expression levels of programmed cell death-ligand (PD-L)1, PD-L2, intracellular adhesion molecule 1 (ICAM-1), IFN-γ, IL-4, IL-5, and IL-10 were evaluated in the infected nasal mucosa. Results:The HRV infection rates were not significantly different between allergy (74.4 %) and non-allergy (72.7 %) groups. In the allergy group, the expression of PD-L1 (P=0.013) and IL-10 (P=0.040) was significantly elevated in the HRV-infected tissues; there was a strong correlation between PDL1 and IL-10 (r= 0.868, P<0.001). In contrast, infected tissues from the non-allergy group displayed increased levels of IL-4 (P=0.039), IL-5 (P=0.023), and IFN-γ (P=0.031) as well as an increased IL-4/IFN-γ ratio after HRV infection (P=0.043). Conclusion:This study shows that, regardless of the presence of allergy, HRV infection rates are similar in the nasal mucosa of patients with CRS. HRV infection enhances the Th2 environment by modulating PD-L1 and PD-L2 expression levels in allergic mucosa and by increasing the IL-4/IFN-γ ratio in non-allergic mucosa.
journal_name
Clin Exp Otorhinolaryngoljournal_title
Clinical and experimental otorhinolaryngologyauthors
Ko YK,Zhang YL,Wee JH,Han DH,Kim HJ,Rhee CSdoi
10.21053/ceo.2020.00444subject
Has Abstractpub_date
2020-09-11 00:00:00eissn
1976-8710issn
2005-0720pii
ceo.2020.00444pub_type
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journal_title:Clinical and experimental otorhinolaryngology
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journal_title:Clinical and experimental otorhinolaryngology
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journal_title:Clinical and experimental otorhinolaryngology
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pub_type: 杂志文章,评审
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更新日期:2010-09-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
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更新日期:2012-09-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
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journal_title:Clinical and experimental otorhinolaryngology
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doi:10.3342/ceo.2012.5.2.94
更新日期:2012-06-01 00:00:00
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doi:10.21053/ceo.2017.01641
更新日期:2018-10-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.2.57
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journal_title:Clinical and experimental otorhinolaryngology
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更新日期:2016-12-01 00:00:00
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doi:10.3342/ceo.2008.1.1.35
更新日期:2008-03-01 00:00:00
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更新日期:2018-12-01 00:00:00
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更新日期:2020-05-01 00:00:00
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更新日期:2013-03-01 00:00:00
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abstract::Allergic rhinitis (AR) is a globally increasing health problem affecting the quality of life. Specific immunotherapy is an available causal treatment changing the basic allergic mechanisms of the disease. Over one hundred years, subcutaneous immunotherapy (SCIT) was developed and proved its efficacy but many adverse e...
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pub_type: 杂志文章,评审
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abstract::Cavernous hemangioma seems to most frequently arise in the posterior portion of the external auditory canal. However, they rarely occur in the tympanic membrane. A 49-year-old male patient was referred for evaluation of right-sided pulsatile tinnitus that he'd experienced for the previous 2 years. Temporal bone comput...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
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