Depression and memory function - evidence from cross-lagged panel models with unit fixed effects in ELSA and HRS.

Abstract:

BACKGROUND:Individuals with depression are often found to perform worse on cognitive tests and to have an increased risk of dementia. The causes and the direction of these associations are however not well understood. We looked at two specific hypotheses, the aetiological risk factor hypothesis and the reverse causality hypothesis. METHOD:We analysed observational data from two cohorts, English Longitudinal Study of Ageing (ELSA) and Health and Retirement Study (HRS), using cross-lagged panel models with unit fixed effects. Each model was run once with depression and repeated with cognition as the dependent variable and the other variable as the main explanatory variable. All models were estimated separately for contemporaneous effects and lagged effects up to 8 years in the past. We contrasted the results with models making the random effects assumption. RESULTS:Evidence from the fixed effects models is mixed. We find no evidence for the reverse causality hypothesis in ELSA and HRS. While there is no evidence for the aetiological risk factors hypothesis in ELSA, results from HRS indicate some effects. CONCLUSION:Our findings suggest that current levels of cognitive function do not influence future levels of depression. Results in HRS provide some evidence that current levels of depressive symptoms influence future cognition.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Jindra C,Li C,Tsang RSM,Bauermeister S,Gallacher J

doi

10.1017/S0033291720003037

subject

Has Abstract

pub_date

2020-09-11 00:00:00

pages

1-9

eissn

0033-2917

issn

1469-8978

pii

S0033291720003037

pub_type

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