Abstract：
PURPOSE:Diarrhea is one of the dose limiting toxicity of irinotecan. SN-38 is main irinotecan metabolite responsible for diarrhea development, which is excreted in glucuronidated form into the intestine. This study aimed to determine the effectiveness of the probiotics in the prevention of irinotecan induced diarrhea due to reduction of intestinal beta-d-glucuronidase activity. METHODS:Between January 2011 and December 2013, 46 patients with colorectal cancer starting a new line of irinotecan based therapy were included. Patients were randomized 1:1 to probiotics (PRO) or placebo (PLA). Probiotic formula Colon Dophilus™, was administered at a dose of 10×10(9)CFU of bacteria tid, orally for 12 weeks of chemotherapy. The study was prematurely terminated due to slow accrual, when 46 of 220 planned patients were accrued. RESULTS:Twenty-three patients were randomized to PRO and 23 patients to PLA. Administration of probiotics compared to placebo led to a reduction in the incidence of severe diarrhea of grade 3 or 4 (0% for PRO vs. 17.4% for PLA, p=0.11), as well as reduction of the overall incidence of diarrhea (39.1% for PRO vs. 60.9% for PLA, p=0.24) and incidence of enterocolitis (0% for PRO vs. 8.7% for PLA). Patients on PRO used less antidiarrheal drugs compared to PLA. There was no infection caused by probiotic strains recorded. CONCLUSIONS:Administration of probiotics in patients with colorectal cancer treated with irinotecan-based chemotherapy is safe and could lead to a reduction in the incidence and severity of gastrointestinal toxicity.
journal_name
Complement Ther Medjournal_title
Complementary therapies in medicineauthors
Mego M,Chovanec J,Vochyanova-Andrezalova I,Konkolovsky P,Mikulova M,Reckova M,Miskovska V,Bystricky B,Beniak J,Medvecova L,Lagin A,Svetlovska D,Spanik S,Zajac V,Mardiak J,Drgona Ldoi
10.1016/j.ctim.2015.03.008subject
Has Abstractpub_date
2015-06-01 00:00:00pages
356-62issue
3eissn
0965-2299issn
1873-6963pii
S0965-2299(15)00053-9journal_volume
23pub_type
杂志文章,随机对照试验abstract：OBJECTIVE:To investigate the effects of ballroom and Latin American dancing classes on turning in people with Parkinson's. DESIGN:This study employed a randomised, controlled, experimental design. SETTING:Dance classes were performed in a community dance centre in Southern England and all assessments took place a gai...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2017.03.012
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:The effect of silymarin supplementation on metabolic status and oxidative stress of subjects with type 2 diabetes mellitus (T2DM) has not been conclusively studied. Therefore, the efficacy of silymarin supplementation in these patients was assessed through a meta-analysis. METHODS:The following databases wer...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.ctim.2018.08.010
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:Sauna bathing is becoming a common activity in many countries and it has been linked to favorable health outcomes. However, there is limited data on the heart rate (HR) and heart rate variability (HRV) responses to an acute sauna exposure. DESIGN:We conducted a single-group, longitudinal study utilizing a pr...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.06.011
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of Sanyinjiao (SP6) with electroacupuncture on labour pain in women during the labour process. METHODS:A total of 350 women in labour from three centres were randomly divided into the electroacupuncture group (acupuncture group), the sham electroacupuncture group (sham group) and the ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ctim.2010.09.001
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:Idiopathic Environmental Intolerance (IEI) is an acquired disorder with multiple recurrent symptoms, which is associated with diverse environmental factors that are tolerated by the majority of people. IEI is an illness of uncertain aetiology, making it difficult to treat using conventional medicine. Therefo...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2012.07.005
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Colonoscopy can be painful and uncomfortable. Aromatherapy is often used for the relief of anxiety or discomfort. Recently, it has been reported that olfactory stimulation induces various physiological effects. We investigated the effects of aromatherapy on anxiety and abdominal discomfort during co...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2017.08.012
更新日期：2017-10-01 00:00:00
abstract：AIMS:To assess patterns of diagnosis, including concordance, and treatment within a clinical trial of traditional acupuncture for low back pain. SETTING:In a pragmatic randomised controlled clinical trial, 148 patients with low back pain, of between 4 weeks and 12 months duration, were randomised to the offer of indiv...
journal_title：Complementary therapies in medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0965-2299(03)00125-0
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVES:To assess chiropractic (DC) and naturopathic doctors' (ND) pediatric care natural health product (NHP) recommendations. DESIGN:Surveys were developed in collaboration with DC and ND educators, and delivered as an on-line national survey. NHP dose, form of delivery, and indications across pediatric age range...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.02.001
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:This study examined whether people thought neurotics were more likely to 'get better' when using CAM rather than orthodox medicine. DESIGN:A total of 165 participants completed a four part questionnaire, in which they were required to read eight vignettes (each about 70 words long) describing a British male ...
journal_title：Complementary therapies in medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1054/ctim.2000.0381
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Although clinical trials are needed to evaluate the efficacy of liquid herbal medicinal products, design of feasible placebos that mimic the appearance, taste, and smell of such products is particularly challenging. OBJECTIVE:The design and feasibility of a liquid placebo for STW5, an herbal medicinal produ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2012.04.003
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVES:This pilot study examined the potential efficacy of cranial electric stimulation for the treatment of insomnia. DESIGN:The researchers tested the hypothesis through a randomized, double-blind, and placebo controlled clinical trial. The researchers approached eligible subjects who scored 21 or above on the P...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2012.11.007
更新日期：2013-02-01 00:00:00
abstract：:Chamomile, as a rich source of phenolic compounds and terpenoids, seems to be an effective approach in the management of chronic conditions such as diabetes mellitus. The aim of this systematic review was to evaluate evidence from animal and human studies of the effects of chamomile on metabolic risk markers and compl...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.102284
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:The primary aim was to describe the characteristics of acupuncture patients and in particular the main problem or symptom for which they were seeking treatment. Our secondary aim was to compare the profiles of acupuncture patients with those of a patient survey undertaken in 1988. METHODS:We used the data fr...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2005.07.006
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of ethnicity as a predictor of the use of complementary and alternative medicine (CAM) among patients with diabetes. DESIGN AND SETTINGS:A 16-item questionnaire investigating CAM use was distributed among patients attending the Taking Control of Your Diabetes (TCOYD) educational confer...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2010.09.007
更新日期：2010-12-01 00:00:00
abstract：:Cardiovascular disease (CVD) is the leading causes of mortality across the world. Some earlier studies have revealed the beneficial effects of fenugreek on the risk factors for CVDs. However, a systematic review and meta-analysis is needed to clarify its effectiveness. Accordingly, the purpose of this study was to ass...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2020.102416
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:To determine whether utilizing yoga as an adjunctive therapy to the medical standard of care for adolescents with inflammatory bowel disease (IBD) is: (1) feasible and acceptable, (2) effective in reducing disease severity, intestinal inflammation and improving wellness. DESIGN:Prospective, non-randomized, ...
journal_title：Complementary therapies in medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ctim.2018.09.007
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Previous studies in Parkinson's Disease (PD) have described benefits of dance for motor and non-motor outcomes, yet few studies specifically look at Dance Therapy (DT) as a specific psychotherapeutic model for PD. DT is the psychotherapeutic use of movement to improve physical, emotional, cognitive, and soci...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2018.07.005
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:To see how lay people group or classify various CAM therapies. DESIGN:Nearly 600 adults rated 39 relatively familiar branches of complementary medicine on four dimensions: whether they had heard of it, whether they think they know how it works; whether they had tried it; and a rating of efficacy on a 10-poi...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1054/ctim.2000.0355
更新日期：2000-06-01 00:00:00
abstract：:Many case studies and several controlled clinical trials have indicated the effectiveness of hypnotherapy for some medical conditions. However, because of methodological inadequacies hypnotherapy is still criticized for not having strong scientific evidence to support its claims. While randomized placebo-controlled cl...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2007.04.005
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVES:To determine the percentage of Emergency Medicine patients using Complementary Therapies (CTs), to investigate what types of CTs are used most commonly, and to gauge the acceptability of studies of CT effectiveness in a hospital setting. METHOD:Prospective cross sectional survey using a convenience sample o...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2009.06.001
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:Although Animal-Assisted Interventions (AAI) are effective treatments for a variety of psychological problems, the mechanism of treatment effectiveness remains unclear. Qualitative studies of AAI may reveal possible mechanisms. This review aims to synthesize qualitative research and identify factors that migh...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2018.10.001
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To study the effectiveness of electro-acupuncture with behavior therapy on preschool children with attention deficit hyperactivity disorder (ADHD). METHODS:180 preschool children with ADHD diagnosed by DSM-IV were classified into three subtypes: predominantly inattentive subtype (PI subtype, 60 cases), predo...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2010.08.002
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating effects. CASE...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2018.04.001
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the use of attitudes to complementary and alternative medicine (CAM) among UK physicians. DESIGN:Postal questionnaire. SUBJECTS:All Members and Fellows of the Royal College of Physicians. RESULTS:Twelve thousand, one hundred and sixty eight Members and Fellows were surveyed and a response rate...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1054/ctim.2001.0475
更新日期：2001-09-01 00:00:00
abstract：:Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain tre...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2020.102394
更新日期：2020-06-01 00:00:00
abstract：:In this paper I critically address what is becoming the wholesale adoption of the concept of complementary medicine in researchers' analyses of lay participation in alternative therapies. This paper emerged out of a qualitative study of 21 Canadians who use and/or practice alternative therapies. I found that only seve...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1054/ctim.2000.0423
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of spa adjuvant therapy on diabetic lower extremity arterial disease (LEAD). METHODS:128 patients with type II diabetes were separated into three groups according to the degree of lower extremity vascular stenosis. Patients within each group were then randomly divided to receive no ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2014.05.003
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of functional-task training on activities of daily living (ADL) in people with Parkinson`s Disease. METHODS:We searched five databases (Cinahl, Embase, Medline, Pedro and CENTRAL). The included studies were assessed on therapeutic validity and risk of bias. We classified the quality of...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.ctim.2018.12.008
更新日期：2019-02-01 00:00:00
abstract：AIMS:To examine the effects of aromatherapy massage on anxiety and sleep quality in patients undergoing colorectal surgery in the preoperative period. BACKGROUND:In recent years, there has been an increase in the number of studies conducted on aromatherapy massage. It is stated that studies conducted on aromatherapy m...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2017.12.002
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Observe the clinical efficacy of l-3-n-Butylphthalide (NBP) in acute ischemic stroke (AIS) patients within 24 h after intravenous thrombolysis using recombinant tissue plasminogen activator (hereafter termed "IT"). METHODS:One-hundred and seventy-eight patients with AIS were divided randomly into two groups:...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2020.102442
更新日期：2020-08-01 00:00:00
