Applying genetics in inflammatory disease drug discovery.

Abstract:

:Recent groundbreaking work in genetics has identified thousands of small-effect genetic variants throughout the genome that are associated with almost all major diseases. These genome-wide association studies (GWAS) are often proposed as a source of future medical breakthroughs. However, with several notable exceptions, the journey from a small-effect genetic variant to a functional drug has proven arduous, and few examples of actual contributions to drug discovery exist. Here, we discuss novel approaches of overcoming this hurdle by using instead public genetics resources as a pragmatic guide alongside existing drug discovery methods. Our aim is to evaluate human genetic confidence as a rationale for drug target selection.

journal_name

Drug Discov Today

journal_title

Drug discovery today

authors

Folkersen L,Biswas S,Frederiksen KS,Keller P,Fox B,Fleckner J

doi

10.1016/j.drudis.2015.05.012

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1176-81

issue

10

eissn

1359-6446

issn

1878-5832

pii

S1359-6446(15)00225-1

journal_volume

20

pub_type

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