Abstract:
:Recent groundbreaking work in genetics has identified thousands of small-effect genetic variants throughout the genome that are associated with almost all major diseases. These genome-wide association studies (GWAS) are often proposed as a source of future medical breakthroughs. However, with several notable exceptions, the journey from a small-effect genetic variant to a functional drug has proven arduous, and few examples of actual contributions to drug discovery exist. Here, we discuss novel approaches of overcoming this hurdle by using instead public genetics resources as a pragmatic guide alongside existing drug discovery methods. Our aim is to evaluate human genetic confidence as a rationale for drug target selection.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Folkersen L,Biswas S,Frederiksen KS,Keller P,Fox B,Fleckner Jdoi
10.1016/j.drudis.2015.05.012subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1176-81issue
10eissn
1359-6446issn
1878-5832pii
S1359-6446(15)00225-1journal_volume
20pub_type
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