Focused ultrasound phantom model for blood brain barrier disruption.

Abstract:

:In this paper a high intensity focused ultrasound (FUS) phantom model was developed, in order to be used in experiments for Blood Brain Barrier (BBB) disruption. The target was to create a phantom model that represents the disruption of the BBB during ultrasound application. An appropriate experimental setup was created bearing a single element transducer with diameter 50 mm and geometric focus 100 mm operating at 0.5 MHz. It included a set of tubes and a connector with multiple 0.4 mm openings, through which a suitable liquid is being circulated with a pump. The lesions were sealed with a thin homogenous layer of wax, preventing a liquid leakage. The system was tested successfully with FUS and a liquid leakage was achieved after FUS application. This set up is the first phantom model that has the potential to be utilized as a cost-effective solution for performing experiments for BBB disruption, without the need of using animal models.

journal_name

Ultrasonics

journal_title

Ultrasonics

authors

Alekou T,Giannakou M,Damianou C

doi

10.1016/j.ultras.2020.106244

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

106244

eissn

0041-624X

issn

1874-9968

pii

S0041-624X(20)30183-9

journal_volume

110

pub_type

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