Estimation of infection prevalence and sensitivity in a stratified two-stage sampling design employing highly specific diagnostic tests when there is no gold standard.

abstract：:When the accrual rate is low and the treatment period is long, a long observational period is required before information concerning the primary end point, such as binary response, becomes available in the study. Simon's two-stage designs are often employed in Phase II clinical trials to avoid giving patient an ineffe...

journal_title：Statistics in medicine

authors： Chi Y,Chen CM

更新日期：2008-12-20 00:00:00

abstract：:In Part I we presented a covariance structure model for analysing measurement error in the assessment of nitrogen intake. In this paper we include data on urine nitrogen excretion which allows a critical assessment of the model proposed. Inclusion of urine nitrogen data produces more pessimistic estimates of the quali...

journal_title：Statistics in medicine

authors： Plummer M,Clayton D

更新日期：1993-05-30 00:00:00

abstract：:We consider the estimation of parameters in a particular segmented generalized linear model with additive measurement error in predictors, with a focus on linear and logistic regression. In epidemiologic studies segmented regression models often occur as threshold models, where it is assumed that the exposure has no i...

journal_title：Statistics in medicine

authors： Küchenhoff H,Carroll RJ

更新日期：1997-01-15 00:00:00

abstract：:In this paper, we construct a partial additive regression (PAR) model to predict the survival times of cancer patients based on microarray gene expression data with right censoring. The area under time-dependent receiver operating characteristic curve is used as a model evaluation criterion. We conduct a simulation st...

journal_title：Statistics in medicine

authors： Zhao Y,Zhou Y,Zhao M

更新日期：2009-01-30 00:00:00

abstract：:The concept of broad sense agreement (BSA) has recently been proposed for studying the relationship between a continuous measurement and an ordinal measurement. They developed a nonparametric procedure for estimating the BSA index, which is only applicable to completely observed data. In this work, we consider the pro...

journal_title：Statistics in medicine

authors： Dai T,Guo Y,Peng L,Manatunga A

更新日期：2020-06-30 00:00:00

abstract：:Longitudinal studies are commonly used to study processes of change. Because data are collected over time, missing data are pervasive in longitudinal studies, and complete ascertainment of all variables is rare. In this paper a new imputation strategy for completing longitudinal data sets is proposed. The proposed met...

journal_title：Statistics in medicine

authors： Landrum MB,Becker MP

更新日期：2001-09-15 00:00:00

abstract：:The analysis of patient-reported outcomes or other psychological traits can be realized using the Rasch measurement model. When the objective of a study is to compare groups of individuals, it is important, before the study, to define a sample size such that the group comparison test will attain a given power. The Ras...

journal_title：Statistics in medicine

authors： Hardouin JB,Blanchin M,Feddag ML,Le Néel T,Perrot B,Sébille V

更新日期：2015-07-20 00:00:00

abstract：:I derive the locally most powerful rank tests for acceleration against semi-parametric alternatives when some patients are cured of the disease. I consider some particular classes of alternatives and present simulation results to verify the validity of the proposed tests. Real data from clinical trials for childhood l...

journal_title：Statistics in medicine

authors： Lee JW

更新日期：1995-10-15 00:00:00

abstract：:For the analysis of time to event data in contraceptive studies when individuals are subject to competing causes for discontinuation, some authors have recently advocated the use of the cumulative incidence rate as a more appropriate measure to summarize data than the complement of the Kaplan-Meier estimate of discont...

journal_title：Statistics in medicine

authors： Farley TM,Ali MM,Slaymaker E

更新日期：2001-12-15 00:00:00

abstract：:This field study sought to measure the effects of dental delivery and school-based, dental health education on use of dental health care by children in grades K-6. We attempted to control for two potential confounding factors by an approximate randomization of children into treatment groups with stratification on grad...

journal_title：Statistics in medicine

authors： Oler J,Bentley JM

更新日期：1983-01-01 00:00:00

abstract：:Conditional power and predictive power provide estimates of the probability of success at the end of the trial based on the information from the interim analysis. The observed value of the time to event endpoint at the interim analysis could be biased for the true treatment effect due to early censoring, leading to a ...

journal_title：Statistics in medicine

authors： Sun L,Wan Y

更新日期：2018-08-15 00:00:00

abstract：:In biomedical literature, numerous prediction models for clinical outcomes have been developed based either on clinical data or, more recently, on high-throughput molecular data (omics data). Prediction models based on both types of data, however, are less common, although some recent studies suggest that a suitable c...

journal_title：Statistics in medicine

authors： De Bin R,Sauerbrei W,Boulesteix AL

更新日期：2014-12-30 00:00:00

abstract：:Adaptive designs or flexible designs in a broader sense have increasingly been considered in planning pivotal registration clinical trials. Sample size reassessment design and adaptive selection design are two of such designs that appear in regulatory applications. At the design stage, consideration of sample size rea...

journal_title：Statistics in medicine

authors： Hung HM,Wang SJ,O'Neill R

更新日期：2011-06-15 00:00:00

abstract：:The 'at least as good as' criterion, introduced by Laster and Johnson for a continuous response variate, is developed here for applications with dichotomous data. This approach is adaptive in nature, as the margin of non-inferiority is not taken as a fixed difference; it varies as a function of the positive control re...

journal_title：Statistics in medicine

authors： Laster LL,Johnson MF,Kotler ML

更新日期：2006-04-15 00:00:00

abstract：:Variation in heart disease (HD) mortality rates across census tracts is greater than expected given binomial error and available explanatory variables. We extended an extra-binomial variation model for rates standardized by the direct method. The overdispersion parameter accounted for 36 per cent of the observed varia...

journal_title：Statistics in medicine

authors： Jarjoura D,Logue E

更新日期：1990-10-01 00:00:00

abstract：:The induced smoothing technique overcomes the difficulties caused by the non-smoothness in rank-based estimating functions for accelerated failure time models, but it is only natural when the estimating function has Gehan's weight. For a general weight, the induced smoothing method does not provide smooth estimating f...

journal_title：Statistics in medicine

authors： Chiou S,Kang S,Yan J

更新日期：2015-04-30 00:00:00

abstract：:Patient compliance (adherence) with prescribed medication is often erratic, while clinical outcomes are causally linked to actual, rather than nominal medication dosage. We propose here a hierarchical Markov model for patient compliance. At the first stage, conditional upon individual random effects and a set of indiv...

journal_title：Statistics in medicine

authors： Girard P,Blaschke TF,Kastrissios H,Sheiner LB

更新日期：1998-10-30 00:00:00

abstract：:Health questionnaires are often built up from sets of questions that are totaled to obtain a sum score. An important consideration in designing questionnaires is to minimize respondent burden. An increasingly popular method for efficient measurement is computerized adaptive testing; unfortunately, many health question...

journal_title：Statistics in medicine

authors： Smits N,Finkelman MD

更新日期：2014-02-10 00:00:00

abstract：:A problem occurring in chronic disease modeling is the estimation of transition probabilities of moving from one state of a categorical risk factor to another. Transitions could be obtained from a cohort study, but often such data may not be available. However, under the assumption that transitions remain stable over ...

journal_title：Statistics in medicine

authors： Kassteele Jv,Hoogenveen RT,Engelfriet PM,Baal PH,Boshuizen HC

更新日期：2012-03-15 00:00:00

abstract：:There is a single-minded focus on events in survival analysis, and we often ignore longitudinal data that are collected together with the event data. This is due to a lack of methodology but also a result of the artificial distinction between survival and longitudinal data analyses. Understanding the dynamics of such ...

journal_title：Statistics in medicine

authors： Aalen OO

更新日期：2012-08-15 00:00:00

abstract：:Antimicrobial resistance has become one of the main public health burdens of the last decades, and monitoring the development and spread of non-wild-type isolates has therefore gained increased interest. Monitoring is performed based on the minimum inhibitory concentration (MIC) values, which are collected through the...

journal_title：Statistics in medicine

authors： Jaspers S,Aerts M,Verbeke G,Beloeil PA

更新日期：2014-01-30 00:00:00

abstract：:The original article to which this Correction refers was published in Statistics in Medicine 2000 19(14): 1901-1914. ...

journal_title：Statistics in medicine

authors： Edwardes MD

更新日期：2000-11-15 00:00:00

abstract：:Group sequential testing procedures have been proposed as an approach to conserving resources in biomarker validation studies. Previously, we derived the asymptotic properties of the sequential empirical positive predictive value (PPV) and negative predictive value (NPV) curves, which summarize the predictive accuracy...

journal_title：Statistics in medicine

authors： Koopmeiners JS,Feng Z

更新日期：2016-04-15 00:00:00

abstract：:To construct a confidence interval for the mean of a log-normal distribution in small samples, we propose likelihood-based approaches - the signed log-likelihood ratio and modified signed log-likelihood ratio methods. Extensive Monte Carlo simulation results show the advantages of the modified signed log-likelihood ra...

journal_title：Statistics in medicine

authors： Wu J,Wong AC,Jiang G

更新日期：2003-06-15 00:00:00

abstract：:We give up-to-date methods for estimating the age-specific incidence of a disease and for estimating the effect of risk factors. We recommend taking age as the basic time scale of the analysis; then, the hazard function can be interpreted as the age-specific incidence of the disease. This choice raises a delayed entry...

journal_title：Statistics in medicine

authors： Commenges D,Letenneur L,Joly P,Alioum A,Dartigues JF

更新日期：1998-09-15 00:00:00

abstract：:Patient reported outcome and observer evaluative studies in clinical trials and post-hoc analyses often use instruments that measure responses on ordinal-rating or Likert scales. We propose a flexible distributional approach by modeling the change scores from the baseline to the end of the study using independent beta...

journal_title：Statistics in medicine

authors： Zou KH,Carlsson MO,Quinn SA

更新日期：2010-10-30 00:00:00

abstract：:Given N points or events occurring according to some probability distribution in the unit interval (0, 1), the simple scan statistic is defined to be the maximum number of points in any sub-interval of length d. In many areas, as in epidemiology, it is used to test the null hypothesis that the events are random, again...

journal_title：Statistics in medicine

authors： Nagarwalla N

更新日期：1996-04-15 00:00:00

abstract：:Systematic reviews often provide recommendations for further research. When meta-analyses are inconclusive, such recommendations typically argue for further studies to be conducted. However, the nature and amount of future research should depend on the nature and amount of the existing research. We propose a method ba...

journal_title：Statistics in medicine

authors： Roloff V,Higgins JP,Sutton AJ

更新日期：2013-01-15 00:00:00

abstract：:The objective of this report is to provide a basis to inform decisions about priorities for developing statistical research initiatives in the field of public health surveillance for emerging threats. Rapid information system advances have created a vast opportunity of secondary data sources for information to enhance...

journal_title：Statistics in medicine

authors： Rolka H,Burkom H,Cooper GF,Kulldorff M,Madigan D,Wong WK

更新日期：2007-04-15 00:00:00

abstract：:One Sentence Summary: A Bayesian repeated measures model based on quantitative muscle strength data from a prospective Natural History Study was developed to determine disease progression and design clinical trials for GNE myopathy, a rare and slowly progressive muscle disease. GNE myopathy is a rare muscle disease ch...

journal_title：Statistics in medicine

authors： Quintana M,Shrader J,Slota C,Joe G,McKew JC,Fitzgerald M,Gahl WA,Berry S,Carrillo N

更新日期：2019-04-15 00:00:00