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Retrospective analysis of the relationship between elevated plasma levels of TXNIP and carotid intima-media thickness in subjects with impaired glucose tolerance and early Type 2 diabetes mellitus.

Abstract：

AIMS:Accelerated atherosclerosis is the major cause of mortality in diabetic patients and increased oxidative stress probably plays an important role in its development. The aim of our study was to evaluate the relationship between thioredoxin-interacting protein (TXNIP) as an oxidative stress parameter and carotid artery intima-media thickness (CIMT) as an indicator of atherosclerosis in patients with early-state diabetes and impaired glucose tolerance. METHODS:The study was a retrospective analysis of 90 patients with impaired glucose regulation (IGR), 80 patients with early Type 2 diabetes mellitus (T2DM), and 80 subjects with normal glucose tolerance (NGT) as the control group. It was conducted at the endocrine out-patient clinic and hospital department of Cangzhou Central Hospital (Cangzhou, China) from June 2012 to Oct. 2013. Plasma TXNIP was measured to evaluate the level of oxidative stress. CIMT was assessed by carotid artery ultrasonography. Soluble vascular cell adhesion molecule-1 (sVCAM-1), a risk indicator for endothelial dysfunction, was also measured. RESULTS:Compared to the NGT control, patients with IGR showed significantly higher plasma levels of TXNIP (P<0.05). Compared to the IGR group, patients with T2DM also had significantly higher plasma levels of TXNIP (P<0.05). CIMT was significantly higher in the subjects with abnormal glucose metabolism than in the NGT group (P<0.05). CIMT showed positive correlations with both TXNIP and sVCAM-1 levels (r = 0.56 and r = 0.49, respectively, both P<0.01). CONCLUSIONS:The present study showed that plasma levels of TXNIP may be a useful predictor of subclinical atherosclerosis in Type 2 diabetic patients.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Zhao Y,Li X,Tang S

doi

10.1016/j.diabres.2015.05.028

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

372-7

issue

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(15)00258-2

journal_volume

109

pub_type

杂志文章

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Retrospective analysis of the relationship between elevated plasma levels of TXNIP and carotid intima-media thickness in subjects with impaired glucose tolerance and early Type 2 diabetes mellitus.